Zobrazeno 1 - 10
of 93
pro vyhledávání: '"I Cancino"'
Autor:
Bastián I. Cortés, Rodrigo C. Meza, Carlos Ancatén-González, Nicolás M. Ardiles, María-Ignacia Aránguiz, Hideaki Tomita, David R. Kaplan, Francisca Cornejo, Alexia Nunez-Parra, Pablo R. Moya, Andrés E. Chávez, Gonzalo I. Cancino
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-15 (2024)
Abstract Background The brain cortex is responsible for many higher-level cognitive functions. Disruptions during cortical development have long-lasting consequences on brain function and are associated with the etiology of brain disorders. We previo
Externí odkaz:
https://doaj.org/article/d4a3502f9ed749f19ffeddc6183b865b
Autor:
América Chandía-Cristi, Daniela A. Gutiérrez, Andrés E. Dulcey, Marcelo Lara, Lina Vargas, Yi-Han Lin, Pablo Jimenez-Muñoz, Gabriela Larenas, Xin Xu, Amy Wang, Ashley Owens, Christopher Dextras, YuChi Chen, Claudio Pinto, Tamara Marín, Hugo Almarza-Salazar, Keryma Acevedo, Gonzalo I. Cancino, Xin Hu, Patricio Rojas, Marc Ferrer, Noel Southall, Mark J. Henderson, Silvana Zanlungo, Juan J. Marugan, Alejandra Álvarez R
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114144- (2024)
Summary: The molecular mechanisms underlying seizure generation remain elusive, yet they are crucial for developing effective treatments for epilepsy. The current study shows that inhibiting c-Abl tyrosine kinase prevents apoptosis, reduces dendritic
Externí odkaz:
https://doaj.org/article/d6f3af7f5f984ae686e586e3fd0a0393
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Neurodevelopmental disorders are characterized by alterations in the development of the cerebral cortex, including aberrant changes in the number and function of neural cells. Although neurogenesis is one of the most studied cellular processes in the
Externí odkaz:
https://doaj.org/article/f5881abd171146b8b06f93671c6a3d76
Autor:
Tamara Marín, Cristian Valls, Carolina Jerez, Tomás Huerta, Daniela Elgueta, René L. Vidal, Alejandra R. Alvarez, Gonzalo I. Cancino
Publikováno v:
IBRO Neuroscience Reports, Vol 13, Iss , Pp 378-387 (2022)
Parkinson's disease is the second most common neurodegenerative disorder. Although it is clear that dopaminergic neurons degenerate, the underlying molecular mechanisms are still unknown, and thus, successful treatment is still elusive. One pro-apopt
Externí odkaz:
https://doaj.org/article/c775d2a7ef1a4dfdb42297089a619ce0
Autor:
Rilda León, Daniela A. Gutiérrez, Claudio Pinto, Cristian Morales, Catalina de la Fuente, Cristóbal Riquelme, Bastián I. Cortés, Adrián González-Martin, David Chamorro, Nelson Espinosa, Pablo Fuentealba, Gonzalo I. Cancino, Silvana Zanlungo, Andrés E. Dulcey, Juan J. Marugan, Alejandra Álvarez Rojas
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
BackgroundGrowing evidence suggests that the non-receptor tyrosine kinase, c-Abl, plays a significant role in the pathogenesis of Alzheimer’s disease (AD). Here, we analyzed the effect of c-Abl on the cognitive performance decline of APPSwe/PSEN1Δ
Externí odkaz:
https://doaj.org/article/6accec4f1b6445c78136a93af6f6172c
Autor:
Alexis Martinez, Cristian M. Lamaizon, Cristian Valls, Fabien Llambi, Nancy Leal, Patrick Fitzgerald, Cliff Guy, Marcin M. Kamiński, Nibaldo C. Inestrosa, Brigitte van Zundert, Gonzalo I. Cancino, Andrés E. Dulcey, Silvana Zanlungo, Juan J. Marugan, Claudio Hetz, Douglas R. Green, Alejandra R. Alvarez
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 2007 (2023)
The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged
Externí odkaz:
https://doaj.org/article/52442aebd7684326868078bfe18e45e8
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Infections during pregnancy can seriously damage fetal neurodevelopment by aberrantly activating the maternal immune system, directly impacting fetal neural cells. Increasing evidence suggests that these adverse impacts involve alterations in neural
Externí odkaz:
https://doaj.org/article/f260db29fc16426d9cea9eca740cc479
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Protein phosphatases are major regulators of signal transduction and they are involved in key cellular mechanisms such as proliferation, differentiation, and cell survival. Here we focus on one class of protein phosphatases, the type IIA Receptor-typ
Externí odkaz:
https://doaj.org/article/3f84b0848e664cd2819799d5a437fd83
Autor:
Hideaki Tomita, Francisca Cornejo, Begoña Aranda-Pino, Cameron L. Woodard, Constanza C. Rioseco, Benjamin G. Neel, Alejandra R. Alvarez, David R. Kaplan, Freda D. Miller, Gonzalo I. Cancino
Publikováno v:
Cell Reports, Vol 30, Iss 1, Pp 215-228.e5 (2020)
Summary: PTPRD is a receptor protein tyrosine phosphatase that is genetically associated with neurodevelopmental disorders. Here, we asked whether Ptprd mutations cause aberrant neural development by perturbing neurogenesis in the murine cortex. We s
Externí odkaz:
https://doaj.org/article/7ced58abe9be4e1787e78a4b2f997c55
Autor:
Elisa Balboa, Juan Castro, María-José Pinochet, Gonzalo I. Cancino, Nuria Matías, Pablo José Sáez, Alexis Martínez, Alejandra R. Álvarez, Carmen Garcia-Ruiz, José C. Fernandez-Checa, Silvana Zanlungo
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 274-284 (2017)
MLN64 is a late endosomal cholesterol-binding membrane protein that has been implicated in cholesterol transport from endosomal membranes to the plasma membrane and/or mitochondria, in toxin-induced resistance, and in mitochondrial dysfunction. Down-
Externí odkaz:
https://doaj.org/article/494d1c1146744392a9897e0212a73156