Zobrazeno 1 - 10
of 3 666
pro vyhledávání: '"I Brown"'
Autor:
Abdul Haseeb Khan, Xuefang Gu, Rutvik J. Patel, Prabha Chuphal, Matheus P. Viana, Aidan I. Brown, Brian M. Zid, Tatsuhisa Tsuboi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract A decline in mitochondrial function is a hallmark of aging and neurodegenerative diseases. It has been proposed that changes in mitochondrial morphology, including fragmentation of the tubular mitochondrial network, can lead to mitochondrial
Externí odkaz:
https://doaj.org/article/74f0995a4c9f4af9a5b2f6c2046a9aa1
Autor:
Joseph J. Cuthbert, Oliver I. Brown, Pierpaolo Pellicori, Karen Dobbs, Jeanne Bulemfu, Syed Kazmi, Ioanna Sokoreli, Steffan C. Pauws, Jarno M. Riistama, John G.F. Cleland, Andrew L. Clark
Publikováno v:
ESC Heart Failure, Vol 11, Iss 2, Pp 950-961 (2024)
Abstract Aims Approximately half of patients with heart failure and a reduced ejection fraction (HeFREF) are discharged from hospital on triple therapy [angiotensin‐converting enzyme inhibitors (ACE‐Is) or angiotensin receptor blockers (ARBs), be
Externí odkaz:
https://doaj.org/article/00be306fc0ac4684a305d252abd8b3d1
Autor:
Andrew MN Walker, Nicole T. Watt, Nadira Y. Yuldasheva, Sanjush Dalmia, Marcella Conning-Rowland, Chew W. Cheng, Nele Warmke, Katherine Bridge, Oliver I. Brown, Cheukyau Luk, Michael Drozd, Natalie J. Haywood, Anna Skromna, Natasha Makava, Stephen B. Wheatcroft, Mark T. Kearney, Richard M. Cubbon
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e36457- (2024)
Objective: Reduced IGF-1 signalling is an evolutionarily conserved mediator of longevity, yet the magnitude of this effect is substantially larger in organisms retaining a common insulin and IGF-1 receptor. Whether this reflects the failure to simult
Externí odkaz:
https://doaj.org/article/8e31cd24581c4d399766217804bdc0d5
Autor:
Giselle L. Saulnier Sholler, Genevieve Bergendahl, Elizabeth C. Lewis, Jacqueline Kraveka, William Ferguson, Abhinav B. Nagulapally, Karl Dykema, Valerie I. Brown, Michael S. Isakoff, Joseph Junewick, Deanna Mitchell, Jawhar Rawwas, William Roberts, Don Eslin, Javier Oesterheld, Randal K. Wada, Devang Pastakia, Virginia Harrod, Kevin Ginn, Raya Saab, Kevin Bielamowicz, Jason Glover, Eugenia Chang, Gina K. Hanna, Daniel Enriquez, Tyler Izatt, Rebecca F. Halperin, Abigail Moore, Sara A. Byron, William P. D. Hendricks, Jeffrey M. Trent
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background Children with relapsed central nervous system (CNS tumors), neuroblastoma, sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial examined the feasibility of combining genomic and transcriptomic
Externí odkaz:
https://doaj.org/article/aabaaa1d731d43219ab2b7d7fb61c753
Autor:
J. Prytherch, S. Murto, I. Brown, A. Ulfsbo, B. F. Thornton, V. Brüchert, M. Tjernström, A. L. Hermansson, A. T. Nylund, L. A. Holthusen
Publikováno v:
Biogeosciences, Vol 21, Pp 671-688 (2024)
The central Arctic Ocean (CAO) plays an important role in the global carbon cycle, but the current and future exchange of the climate-forcing trace gases methane (CH4) and carbon dioxide (CO2) between the CAO and the atmosphere is highly uncertain. I
Externí odkaz:
https://doaj.org/article/49d4797e04594edb9d0f358674ac8f4c
Autor:
A. J. McEvoy, A. Atkinson, R. L. Airs, R. Brittain, I. Brown, E. S. Fileman, H. S. Findlay, C. L. McNeill, C. Ostle, T. J. Smyth, P. J. Somerfield, K. Tait, G. A. Tarran, S. Thomas, C. E. Widdicombe, E. M. S. Woodward, A. Beesley, D. V. P. Conway, J. Fishwick, H. Haines, C. Harris, R. Harris, P. Hélaouët, D. Johns, P. K. Lindeque, T. Mesher, A. McQuatters-Gollop, J. Nunes, F. Perry, A. M. Queiros, A. Rees, S. Rühl, D. Sims, R. Torres, S. Widdicombe
Publikováno v:
Earth System Science Data, Vol 15, Pp 5701-5737 (2023)
The Western Channel Observatory (WCO) comprises a series of pelagic, benthic and atmospheric sampling sites within 40 km of Plymouth, UK, that have been sampled by the Plymouth institutes on a regular basis since 1903. This longevity of recording and
Externí odkaz:
https://doaj.org/article/dd1ec4303738429bbb306cde6fdb2d68
Autor:
Philip Lavretsky, Jonathon E. Mohl, Pär Söderquist, Robert H. S. Kraus, Michael L. Schummer, Joshua I. Brown
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract The translocation of individuals around the world is leading to rising incidences of anthropogenic hybridization, particularly between domestic and wild congeners. We apply a landscape genomics approach for thousands of mallard (Anas platyrh
Externí odkaz:
https://doaj.org/article/41e87a3edbf6417aaa9722216e7dd1be
Autor:
Michael A. Akpe, Gideon A. Okon, Hitler Louis, Innocent Benjamin, Martilda U. Akem, Onyebuenyi I. Brown, Stephen A. Adalikwu, Adedapo S. Adeyinka
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Owing to the fact that the use of 2,2-dichlorovinyldimethylphosphate (DDVP) as an agrochemical has become a matter of concern due to its persistence and potential harm to the environment and human health. Detecting and addressing DDVP contam
Externí odkaz:
https://doaj.org/article/35e8a47f0de24f82b5dc57052ed52e0d
Publikováno v:
Engineering Microbiology, Vol 3, Iss 4, Pp 100104- (2023)
AB5-type toxins are a group of secreted protein toxins that are central virulence factors for bacterial pathogens such as Shigella dysenteriae, Vibrio cholerae, Bordetella pertussis, and certain lineages of pathogenic Escherichia coli and Salmonella
Externí odkaz:
https://doaj.org/article/b835135fdc2a473ab3ed16ab0a2c8976
Autor:
Michael G. Sugiyama, Aidan I. Brown, Jesus Vega-Lugo, Jazlyn P. Borges, Andrew M. Scott, Khuloud Jaqaman, Gregory D. Fairn, Costin N. Antonescu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The epidermal growth factor receptor (EGFR) is a central regulator of cell physiology. EGFR is activated by ligand binding, triggering receptor dimerization, activation of kinase activity, and intracellular signaling. EGFR is transiently con
Externí odkaz:
https://doaj.org/article/a76bca4ec1bb40f1bbe42379e8c8888d