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The Role of Dll4/Notch Signaling in Normal and Pathological Ocular Angiogenesis: Dll4 Controls Blood Vessel Sprouting and Vessel Remodeling in Normal and Pathological Conditions

Autor: Natalia Mikhailova, I. B. Lobov

Publikováno v: Journal of Ophthalmology, Vol 2018 (2018)
Journal of Ophthalmology

Background. Retina is the highest oxygen-demanding and vascularized tissue in the body. Retinal development and function require proper vascularization and blood vessel function and integrity. Dll4 is most prominently expressed in the endothelium of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18cbb99e1f44d596a86aed6650a635b
https://doaj.org/article/c75a3bb9576e4ee494380885d58f41c0

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A Telomere-Binding Protein (TRF2/MTBP) from Mouse Nuclear Matrix with Motives of an Intermediate Filament-Type Rod Domain

Autor: Eric Gilson, Olga I. Podgornaya, I. B. Lobov, A.P. Voronin

Publikováno v: Journal of Anti-Aging Medicine. 6:205-218

In previous work, we identified a telomeric DNA-binding protein (termed telomere-membrane binding protein, MTBP) in the envelope of the frog oocyte nucleus and raised antibodies against it. Here we present immunological evidence which suggests strong

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b465349982babc01e14af954a53631a
https://doi.org/10.1089/109454503322733054

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Specificity of SAF-A and lamin B binding in vitro correlates with the satellite DNA bending state

Autor: A. R. Mitchell, Olga I. Podgornaya, Ken Tsutsui, I. B. Lobov

Publikováno v: Journal of Cellular Biochemistry. 83:218-229

There is evidence that Matrix Attachment Region (MAR)-binding proteins also bind satellite DNA (satDNA). The aim of the current work was to determine whether the major nuclear matrix (NM) MAR-binding proteins are able to recognize satDNAs of differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5011375dcd0d6d59b1bc82e71c8963a
https://doi.org/10.1002/jcb.1220

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SAF-A/hnRNP-U localization in interphase and metaphase

Autor: Piergiorgio Percipalle, Alexander Kukalev, Olga I. Podgornaya, I B Lobov

Publikováno v: Cytogenetic and genome research. 124(3-4)

SAF-A/hnRNP U is an abundant nuclear protein that interacts specifically with nuclear matrix attachment region DNA (MAR) and RNA as a component of hnRNPs. SAF-A/hnRNP U was also shown to specifically bind mouse major satellite DNA (satMa). Antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b4c6b962c309726dc0b8c0a36d89b3
https://pubmed.ncbi.nlm.nih.gov/19556781

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Structure-specific DNA-binding proteins as the foundation for three-dimensional chromatin organization

Autor: O I, Podgornaya, A P, Voronin, N I, Enukashvily, I V, Matveev, I B, Lobov

Publikováno v: International review of cytology. 224

Any functions of tandem repetitive sequences need proteins that specifically bind to them. Telomere-binding TRF2/MTBP attaches telomeres to the nuclear envelope in interphase due to its rod-domain-like motif. Interphase nuclei organized as a number o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8781f352e5491556f9a4040c3a33caa9
https://pubmed.ncbi.nlm.nih.gov/12722952

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Structure-specific DNA-binding proteins as the foundation for three-dimensional chromatin organization

Autor: I. B. Lobov, I V Matveev, A.P. Voronin, N. I. Enukashvily, Olga I. Podgornaya

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d7923fa7f60e0522981b605d2e7d5de
https://doi.org/10.1016/s0074-7696(05)24006-8

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Specific interaction of mouse major satellite with MAR-binding protein SAF-A

Autor: A. R. Mitchell, Ken Tsutsui, I. B. Lobov, Olga I. Podgornaya

Publikováno v: European journal of cell biology. 79(11)

Summary A DNA-binding activity specific to the major mouse satellite (satMa) has been detected in a nuclear matrix protein extract by electrophoretic mobility shift assays (EMSA) after fractionation by ion exchange chromatography. An antibody raised

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beff4ccb9911d2f0184d17b84f09f5d0
https://pubmed.ncbi.nlm.nih.gov/11139148

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[Telomere-binding protein of mouse nuclear matrix. I. Characteristics]

Autor: A P, Voronin, I B, Lobov, E A, Bugaeva, V N, Parfenov, O I, Podgornaia

Publikováno v: Molekuliarnaia biologiia. 33(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae8cc3759d01d4f8837d1babba654537
https://pubmed.ncbi.nlm.nih.gov/10546220

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[Telomere-binding protein of mouse nuclear matrix. II. Localization]

Autor: A P, Voronin, I B, Lobov, E A, Bugaeva, V N, Parfenov, O I, Podgornaia

Publikováno v: Molekuliarnaia biologiia. 33(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ff6c7fc7da1868a83d87ed4a2311eaf
https://pubmed.ncbi.nlm.nih.gov/10546221

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[Role of nuclear matrix proteins in the formation of heterochromatin]

Autor: I B, Lobov, O I, Podgornaia

Publikováno v: Tsitologiia. 41(7)

Heterochromatin consists mainly of satellite DNAs (stDNA), the most rapidly evolving type of DNA sequences of the eucaryotic genome. On the other hand, stDNA is involved in the formation of the functionally conserved centromere structure. Centromeres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fcf6b15dee715545bfb81b0eb5dccc37
https://pubmed.ncbi.nlm.nih.gov/10496017

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