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Publikováno v:
Psychopharmacology. 156:402-409
Rationale:L-Dopa induces dyskinesias during the treatment of Parkinson's disease and also in primates with nigrostriatal lesions produced by MPTP, but it is claimed that L-dopa does not provoke dyskinesia in humans or monkeys with an intact or mildly
Publikováno v:
Acta Neurologica Scandinavica. 65:188-189
Autor:
H, Haikala, I B, Linden
Publikováno v:
Journal of cardiovascular pharmacology. 26
This review compares the mechanisms of action of the calcium-sensitizing agents levosimendan, pimobendan, MCI-154, and EMD 53998. By using purified human recombinant troponin-C (cTnC), the role of cTnC as a target protein for these compounds was inve
Autor:
P. A. Aho, I.-B. Linden
Publikováno v:
Scandinavian journal of gastroenterology. 27(2)
Nitecapone (3-100 mg/kg orally) dose-dependently (40-97%) decreased the macroscopic gastric lesions induced by ethanol, NaOH, or HCl in the rat. The duration of protection was long, being still 70% at 6 h after dosing. Nitecapone (10-100 mg/kg orally
Publikováno v:
Journal of Pharmaceutical Sciences. 73:106-108
□ A series of 2-acylaminoethanesulfonamides were synthesized by treating the corresponding sulfonyl chlorides with ammonia, a primary, or a secondary amine. A few compounds displayed marked anticonvulsant activity in mice when tested for their pote
Autor:
Sudrik, Vilas1 (AUTHOR), Bodkhe, Arjun2 (AUTHOR), Lawande, Shamrao1 (AUTHOR), Suryawanshi, Manohar1 (AUTHOR)
Publikováno v:
Polycyclic Aromatic Compounds. 2023, Vol. 43 Issue 3, p2071-2079. 9p.
Autor:
R, Bäckström, E, Honkanen, A, Pippuri, P, Kairisalo, J, Pystynen, K, Heinola, E, Nissinen, I B, Linden, P T, Männistö, S, Kaakkola
Publikováno v:
Journal of medicinal chemistry. 32(4)
A series of disubstituted catechol derivatives was synthesized and tested as potential COMT inhibitors. The most active compounds were more than 1000 times more potent (IC50 = 3-6 nM) in vitro than the known COMT inhibitor, 3',4'-dihydroxy-2-methylpr
Publikováno v:
Acta dermato-venereologica. 59(5)
Publikováno v:
Neurochemistry international. 5(3)
A number of 2-phthalimidoethanesulphonamides, new derivatives of the inhibitory neuromodulator taurine, were tested for their anticonvulsant activity in maximal electroshock seizure and pentetrazole seizure threshold tests in mice. Certain lower N-al