Zobrazeno 1 - 10
of 132
pro vyhledávání: '"I B, Tsorin"'
Autor:
I. B. Tsorin, L. V. Kozhevnikova, S. A. Simonenko, I. F. Sukhanova, M. B. Vititnova, S. A. Kryzhanovskii
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 12-19 (2024)
Purpose of the study. Search for an optimal approach to developing a translational model of endothelial dysfunction (ED).Materials and methods. The experiments were carried out on 58 white male rats, which were randomized into 8 groups: 1st (n = 6)
Externí odkaz:
https://doaj.org/article/200c0bcd040a4d72b303969d990553c0
Autor:
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, M. B. Vititnova, S. A. Simonenko, L. G. Kolik
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 26-33 (2024)
Purpose of the study. Studying the features of microcirculation, functional state and anatomy of the heart using the “Holiday Heart” syndrome model in rats we developed.Materials and methods. Experiments were carried out on white outbred male rat
Externí odkaz:
https://doaj.org/article/31b3d4cfa09a493ca43371643ec930e3
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 43-49 (2024)
Purpose of the study. Studying the blood microcirculation characteristics in the brain and heart of rats with ACM.Materials and methods. The study was carried out on white outbred male rats. The animals were randomized into 2 groups: 1st (n = 7) —
Externí odkaz:
https://doaj.org/article/c05ef820db57481bbe0b28ddbd795c96
Autor:
I. B. Tsorin, S. A. Kryzhanovskii
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 23-26 (2024)
The purpose of the study is a theoretical justification (working hypothesis) of a possible approach to calculating doses in a combined medicinal product containing 2 pharmaceutical substances. A mathematical model is proposed, which is a multiple reg
Externí odkaz:
https://doaj.org/article/f218b23cc4be444999312f5114e4af10
Autor:
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, V. V. Barchukov, V. N. Stolyaruk, M. B. Vititnova, L. G. Kolik, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 82-93 (2023)
Background. Earlier, on the translational model of alcoholic cardiomyopathy (ACMP) developed by us in outbred white rats, which reproduces the main clinical diagnostic signs of this disease, it was shown that in rats of both sexes under conditions of
Externí odkaz:
https://doaj.org/article/0105e1608a7d4ea5a72c22416b064989
Autor:
V. V. Barchukov, V. P. Zinchenko, I. B. Tsorin, I. Yu. Teplov, V. N. Stolyaruk, M. B. Vititnova, G. V. Mokrov, S. A. Kryzhanovskii
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 56-67 (2023)
Introduction. Cardiovascular diseases (CVD) remain one of the leading causes of death worldwide, claiming over 17 million lives annually. This highlights the urgent need to develop innovative drugs to combat CVD. One potential target for such drugs i
Externí odkaz:
https://doaj.org/article/abacddeba6224d1298b7e2f4a400518a
Autor:
V. V. Barchukov, V. N. Stolyaruk, I. B. Tsorin, M. B. Vititnova, S. А. Kryzhanovskii, T. Yu. Vorobieva, V. E. Biryukova, G. V. Mokrov
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 20-28 (2023)
The antiarrhythmic activity of bis-alkoxyphenyltriazaalkanes 1 and bis-alkoxyphenyldiazaalkanes 2 was analyzed in a model of reperfusion arrhythmia in rats. It was found that the key requirements for the compounds activity in this model are the use o
Externí odkaz:
https://doaj.org/article/3095327cb2ce41c497cc79c5d689f697
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 14-19 (2023)
Relevance. Alcoholic cardiomyopathy (ACMP) is the leading cause of mortality in chronic disease, which is largely associated with an increased risk of developing malignant diseases of the cardiovascular disease. Search for new drugs, including those
Externí odkaz:
https://doaj.org/article/8c3f1e25ec8d45299c17ec2fff17907e
Autor:
I. B. Tsorin
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 3-23 (2023)
The article discusses various types of variance analysis: one-factor, two-factor, repeated measurements, including detailed analysis of variance categorical data. The criteria of multiple comparisons are described: according to Bonferroni, according
Externí odkaz:
https://doaj.org/article/e915110a907a4ae9b5b3afccbc48afac
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 20-25 (2023)
The aim of the work is to study the effect of the anxiolytic fabomotizole (15 mg/kg, i.v.) on atrial depolarization in the acute phase of myocardial infarction using the method of synchronous multichannel cardioelectrochronotopography. Synchronous mu
Externí odkaz:
https://doaj.org/article/9f239bfd7afc43dba968fe2c233eb2fa