Zobrazeno 1 - 10 of 18 pro vyhledávání: '"I B, Koptiaeva"'
1
[New cold-adapted donor strains for live influenza vaccine]
Autor: Iu Z, Gendon, S G, Markushin, T M, Tsfasman, I I, Akopova, N K, Akhmatova, I B, Koptiaeva
Publikováno v: Voprosy virusologii. 58(1)
Cold-adapted (CA) strains A/Krasnodar/35 and B/Victoria/63 were isolated using passages of A/Krasnodar/101/59 and B/Victoria/2/87 wild type strains at low temperatures. The resulting CA strains possessed TS and CA phenotypes and had a reduced ability
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f646ff7c5951825de56320a2af8ed7ab
https://pubmed.ncbi.nlm.nih.gov/23785755
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2
[Investigation of antiviral activity of adamantan boron derivaties on pandemic influenza virus models]
Autor: S G, Markushin, N A, Kantarov, S V, Artiushenko, I I, Akopova, I B, Koptiaeva, Iu N, Bubnov
Publikováno v: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 56(5-6)
Comparative investigation of the virus-inhibiting activity of some boron-containing compounds showed that products BG 12 and BG 4 had the highest inhibitory effect on pandemic viruses. The minimum inhibitory concentration (MIC) of the products was 0.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18a3fc01f3e9e23c2d00141ef6c6c19f
https://pubmed.ncbi.nlm.nih.gov/22145224
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3
[Molecular mechanisms of reversions to the ts+ -phenotype of cold-adapted influenza virus A strains--attenuation donors for live influenza reassortant vaccines]
Autor: S G, Markushin, I I, Akopova, I B, Koptiaeva, T M, Tsfasman, Iu Z, Gendon
Publikováno v: Voprosy virusologii. 51(5)
A ts+ revertant of cold-adapted (ca) strain A/Leningrad/134/47/57--the attenuation donor for live influenza reassortant vaccines--was obtained by passages of the ca strain in chick embryos at nonpermissive temperatures. The ts+ revertant acquired the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c02c9a8eee4e31039d43c2ed2bb98da
https://pubmed.ncbi.nlm.nih.gov/17087060
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4
[Further development (MDCK) of live cold-adapted influenza vaccine: cultivation of vaccine strains in production fermenters]
Autor: Iu Z, Gendon, S G, Markushin, I I, Akopova, I B, Koptiaeva, E A, Nechaeva, I A, Mazurkova, I F, Radaeva, T D, Kolokol'tsova
Publikováno v: Voprosy virusologii. 50(2)
Optimal conditions were developed for cultivating the cold-adapted reassortant live influenza vaccine (CARLIV) in MDCK cells, which were in their turn cultivated in fermenters with serum-free medium and microcarrier. The use of MDCK cells meets all n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d9b6e1ef2b57601710cfe15c8e909eb
https://pubmed.ncbi.nlm.nih.gov/15881389
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5
[Genetic characterisation of wild measles strains circulating in European part of Russia in 1998-2002]
Autor: S G, Markushin, I B, Koptiaeva, P, Rota, M A, Burchik, E F, Sedak
Publikováno v: Voprosy virusologii. 49(4)
The primary structure of the N-gene COOH terminus of measles virus isolated, 1998-2000, in Russia's European part was investigated. The general analysis as well as an analysis of the primary gene structure showed the two group's isolates as belonging
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::444406ebacd3066d69e621afda029090
https://pubmed.ncbi.nlm.nih.gov/15293505
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6
[Features of primary structure of genes and proteins from passaged variations of measles virus]
Autor: S G, Markushin, L Iu, Taros, P, Rota, V, Bellini, I B, Koptiaeva
Publikováno v: Voprosy virusologii. 46(5)
Primary structure and proteins of measles virus variants passaged in tissue culture were studied. The findings suggest that genetic determinants responsible for measles virus attenuation are not linked with the genes coding for envelope proteins and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a5fd048210af0a7d757fdff686f942f
https://pubmed.ncbi.nlm.nih.gov/11715703
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8
[Chronic infection of HEp-2 cells with the L-16 vaccinal strain of the measles virus]
Autor: I B, Koptiaeva, N N, Bogomolova
Publikováno v: Voprosy virusologii. 27(3)
Chronic infection of HEp-2 cells with the vaccine L-16 strain of measles virus was produced. HEp-2 culture infected with the measles virus (HEp-2 MV) is characterized by the presence of the virus-specific antigen in 95% of the cells, adsorption of si
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c2801b7e2e0db779363980001993284
https://pubmed.ncbi.nlm.nih.gov/6750923
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9
[Analysis of the possible mechanisms for the persistence of the vaccinal strain of the measles virus in a human cell culture]
Autor: O G, Andzhaparidze, N N, Bogomolova, Iu S, Boriskin, I B, Koptiaeva, N M, Chaplygina
Publikováno v: Voprosy virusologii. 33(3)
The mechanisms (factors) of the measles virus vaccine L-16 strain persistence in HEp-2 cell culture were analysed. Among the known mechanisms, most likely is the reduction of the cell-destroying properties of the persisting virus due to mutations in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c51924fb225f9a30f40533b1b7bac17
https://pubmed.ncbi.nlm.nih.gov/3176432
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