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Akademický článek

The Peptide Hormone CNMa Influences Egg Production in the Mosquito Aedes aegypti

Autor: Nia I. Keyes-Scott, Aryan Lajevardi, Kyle R. Swade, Mark R. Brown, Jean-Paul Paluzzi, Kevin J. Vogel

Publikováno v: Insects, Vol 13, Iss 3, p 230 (2022)

Mosquito reproduction is regulated by a suite of hormones, many acting through membrane-bound receptor proteins. The Aedes aegypti G protein-coupled receptors AAEL024199 (AeCNMaR-1a) and AAEL018316 (AeCNMaR-1b) were identified as orthologs of the Dro

Externí odkaz: https://doaj.org/article/fce15024322c4b88abacbcf0ca859565

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Akademický článek

The extra-articular impacts of rheumatoid arthritis: moving towards holistic care

Autor: I. C. Scott, A. Machin, C. D. Mallen, S. L. Hider

Publikováno v: BMC Rheumatology, Vol 2, Iss 1, Pp 1-15 (2018)

Abstract Although treat-to-target has revolutionised the outcomes of patients with rheumatoid arthritis (RA) there is emerging evidence that attaining the target of remission is insufficient to normalise patients’ quality of life, and ameliorate th

Externí odkaz: https://doaj.org/article/3e966a498d4d4e9090bb63a93a070698

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Akademický článek

Relationship Between Drosophila suzukii and Postharvest Disorders of Sweet Cherry (Prunus avium)

Autor: M.-M. Ayyanath, C. L. Zurowski, I. M. Scott, D. T. Lowery, M. C. Watson, D. T. O’Gorman, K. E. MacKenzie, J. R. Úrbez-Torres

Publikováno v: Phytobiomes Journal, Vol 2, Iss 1, Pp 42-50 (2018)

Spotted wing drosophila, Drosophila suzukii, utilizes intact ripe fruits for oviposition and larval development. Sweet cherry (Prunus avium) and D. suzukii share a saprophytic microbial community, or microbiome, that colonizes the interior and exteri

Externí odkaz: https://doaj.org/article/9dd995058f5e4ce48e6b8b048b82f11f

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RNAi-mediated knockdown of two orphan G-protein coupled receptors reduces fecundity in the yellow fever mosquitoAedes aegypti

Autor: Nia I. Keyes-Scott, Kyle R. Swade, Lena R. Allen, Kevin J. Vogel

G-protein coupled receptors (GPCRs) control numerous physiological processes in insects, including reproduction. While many GPCRs have known ligands, orphan GPCRs do not have identified ligands in which they bind. Advances in genomic sequencing and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::baf01a56059fd9e162df2a2e12820a48
https://doi.org/10.1101/2023.03.30.534942

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Population PK/PD modelling of the anti-IL-33 antibody tozorakimab to predict pulmonary target engagement in patients with COPD

Autor: M W Sadiq, H Yu, M Astrand, I C Scott, A Williams, L Hewitt, N White, H Killick, M Gavala, F Reid, C Kell, H Pandya, E Jimenez

Publikováno v: 05.03 - Allergy and immunology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22209eaa9cb16947b6c59bd2b1f7dad0
https://doi.org/10.1183/13993003.congress-2022.1815

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Tozorakimab: a dual-pharmacology anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction

Autor: I C Scott, E England, D G Rees, T Erngren, C Chaillan Huntington, K F Houslay, D A Sims, C Hollins, E C Hinchy, C Colley, D J Corkill, E S Cohen

Publikováno v: 05.01 - Airway pharmacology and treatment.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e5ec96827e28a40808419e77b522376
https://doi.org/10.1183/13993003.congress-2022.2467

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Oxidised IL-33 signals via RAGE/EGFR to drive a COPD-associated phenotype

Autor: S Strickson, K F Houslay, V A Negri, Y Ohne, T Ottosson, R B Dodd, C Chaillan Huntington, J Li, H Killick, D G Rees, S Koch, G P Sims, I C Scott, X Romero Ros, E S Cohen

Publikováno v: 03.02 - Airway cell biology and immunopathology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::910e2b12d9f9b5ccf5913265d2b70276
https://doi.org/10.1183/13993003.congress-2022.2482

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A brief behavioral treatment for unresolved insomnia in adolescents: a single-case multiple baseline pilot study, evaluating self-reported outcomes of efficacy, safety, and acceptability

Autor: Christopher B. Miller, David J. Hawes, Gregory I Quartly-Scott

Publikováno v: J Clin Sleep Med

STUDY OBJECTIVES: Insomnia is a significant problem for many adolescents and often is associated with detrimental effects on physical and mental health. Drawing on emerging models of intervention in the adult literature, this pilot study investigated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9852072d023d55839f85747e3afa685
https://europepmc.org/articles/PMC7053007/

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The cardiovascular safety of the empirical measurement of the seizure threshold in electroconvulsive therapy

Autor: Charles Morton, Allan I. F. Scott, Lindsay Mizen

Publikováno v: BJPsych Bulletin

Aims and methodThe Royal College of Psychiatrists' Committee on Electroconvulsive Therapy (ECT) and Related Treatments advises the measurement of initial seizure threshold in all patients undergoing ECT if possible. The subconvulsive electrical stimu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412cb810c05b49c5586664358bdf5edd
https://doi.org/10.1192/pb.bp.112.038695

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