Zobrazeno 1 - 10
of 43
pro vyhledávání: '"I A, Miroshkina"'
Autor:
S. V. Alekseeva, A. V. Sorokina, A. V. . Volkova, I. A. Miroshkina, K. S. Kachalov, I. V. Alekseev, A. D. Zakharov, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 63-69 (2024)
Relevance. Acute toxicity testing is a common procedure for preclinical safety testing of potential agents. The purpose of this study was to study the acute toxicity of the compound GIZH-272, a new dibenzofuran oxime derivative with anti-ischemic and
Externí odkaz:
https://doaj.org/article/9f3cd64f6b014c02b599645f3bbfa364
Autor:
A. V. Chupin, N. R. Masalimov, T. P. Baitman, A. A. Gritskevich, V. A. Kulbak, I. V. Miroshkina, E. V. Kondratyev, Ya. A. Stepanova, I. E. Timina
Publikováno v:
Issledovaniâ i Praktika v Medicine, Vol 10, Iss 4, Pp 119-131 (2023)
Currently, strategies for the management of tumor diseases of the urinary tract in combination with cardiovascular pathologies are controversial. In domestic literature, only isolated reports are found concerning the treatment of combined oncological
Externí odkaz:
https://doaj.org/article/b91f7f6a2ff64cb2ad6fb19856d6771c
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 41-44 (2023)
Purpose of the study. Comparative evaluation of echocardiographic and morphometric dimensions of the rat heart left ventricle. Materials and methods. The study included 10 outbred male rats weighing 160–180 g. The size of the heart left ventricle w
Externí odkaz:
https://doaj.org/article/fe6c583d8ecc4d4a8996fb04c412807d
Autor:
A. V. Sorokina, S. V. Alekseeva, I. A. Miroshkina, A. V. Volkova, K. S. Kachalov, A. D. Zakharov, I. V. Alekseev, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 51-57 (2023)
Relevance. Assay of acute toxicity is a mandatory step in a preclinical safety study of medicines and pharmaceutical substances. The purpose of this study was to determine the parameters of acute toxicity of the substance GIZH-298. Methods. GIZH-298
Externí odkaz:
https://doaj.org/article/ef86978f9c8a4bdfaae7aaadec7b4c86
Autor:
A. V. Sorokina, A. K. Zhanataev, Z. V. Chayka, I. A. Miroshkina, A. A. Lisitsyn, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 43-49 (2023)
Relevance. Diabetes mellitus is a widespread, socially significant disease. In this regard, it is important to obtain an experimental model that precedes subsequent experiments on pharmacological screening and/or study of the mechanism of action of a
Externí odkaz:
https://doaj.org/article/14530dc5a30c4743bd511c7360f119d2
Autor:
I. A. Miroshkina, A. V. Sorokina, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, S. A. Kryzhanovskiy, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 29-35 (2022)
The purpose of the study. Investigation of the effect of the fabomotizol dihydrochloride systematic therapy on the morphological picture of the heart left ventricle (LV) in rats in the subacute period of myocardial infarction. Materials and methods.
Externí odkaz:
https://doaj.org/article/65d03b50b2dd4332974fe79367d38a0a
Autor:
E. S. Pekeldina, I. A. Miroshkina, A. V. Sorokina, N. M. Sazonova, M. B. Vititnova, S. A. Kryzhanovskiy
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 24-28 (2022)
Earlier, in experiments in vitro and in vivo, it was shown that the TrkA receptor agonist compound GK-2, which was a low molecular weight NGF mimetic, had pronounced angiogenic and antiischemic activity. However, it remained unclear whether this acti
Externí odkaz:
https://doaj.org/article/810babfea0bf42b09d59bb669ea6d274
Autor:
I. A. Miroshkina, L. M. Kozhevnikova, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, S. A. Kryzhanovskii, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 30-37 (2021)
It is known that the alcoholic cardiomyopathy (ACMP) is the main reason for lethality from chronic alcoholism. For ACMP the risk of development of malignant violations of a heart rhythm which result approximately at 40% of such patients is sudden hea
Externí odkaz:
https://doaj.org/article/a6f87f8d7fc042e2a81daf443f7f900f
Autor:
I. A. Miroshkina, A. V. Sorokina, A. V. Volkova, V. V. Zabrodina, I. V. Alekseev, K. S. Kachalov, A. D. Zakharov, S. V. Alekseeva
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 48-54 (2021)
Assessment of acute toxicity is a necessary stage of preclinical research of the substance GIZh-298. The aim of present research is study of acute toxicity GIZh-298. Methods. GIZh-298 was administered once intraperitoneally to mice at doses 200-330 m
Externí odkaz:
https://doaj.org/article/7bfeef5dee464153a9653469184eb86e
Autor:
S. V. Alekseeva, A. V. Sorokina, A. V. Volkova, V. V. Zabrodina, I. A. Miroshkina, K. S. Kachalov, I. V. Alekseev, A. D. Zaharov
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 41-47 (2021)
Acute toxicity testing is a commonly accepted procedure for preclinical testing of the safety of potential drugs. The compound GIZh-290, which is a derivative of 4-phenylpyrrolidone– 2,6 - dimethylanilide (2-oxo-4-phenylpyrrolidine-1-yl) acetic aci
Externí odkaz:
https://doaj.org/article/db80459bf14e45c7ad27c46238858579