Výsledky vyhledávání - "I A, Kostanian"

[STAT1: a many-sided transcription factor]

Autor: I A, Kostanian, A V, Vonarshenko, V M, Lipkin

Publikováno v: Bioorganicheskaia khimiia. 36(1)

Cell homeostasis is regulated by numerous signaling proteins. Their main task is to process extracellular signals and activate the intracellular cascades of reactions that lead to the modulation of gene activity. One of the important signaling system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eace18fda06d9188d79b6d030c784453
https://pubmed.ncbi.nlm.nih.gov/20386575

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[Antitumor properties of a liposomal form of a differentiation factor HLDF fragment in cultured cells]

Autor: A V, Bateneva, O A, Babenko, E D, Danilenko, V D, Poryvaev, N N, Karpyshev, E P, Goncharova, I A, Kostanian, V I, Masycheva

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 73(2)

Cytotoxic properties of a liposomal form of the HLDF6 hexapeptide, representing an HL-60 cell differentiation factor fragment, have been studied on a murine primary lymphosarcoma cell culture. It is established that the liposomal HLDF6 peptide is cap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c285cc4c4cec6ff0047d63130555bd3
https://pubmed.ncbi.nlm.nih.gov/20369596

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[Investigation of antitumor activity of the hexamer fraction of HLDF-6 peptide as a differentiation factor in hemoblastoma-bearing mice]

Autor: E D, Danilenko, G M, Sysoeva, S Iu, Ustimenko, V V, Samukov, I A, Kostanian, V I, Masycheva

Publikováno v: Voprosy onkologii. 55(6)

A study of antitumor properties of HLDF-6 was carried out in DBA/2 mice with transplantable ascites lympholeukemia P-388 as well as in tumor cell culture. Immunomodulating characteristics were evaluated. Five-fold administration of HLDF-6 peptide to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c47f05850897f0162753a4031a176c9a
https://pubmed.ncbi.nlm.nih.gov/20210021

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[The proapoptotic factor HLDF in the normal, hyperplastic and neoplastic endometrium]

Autor: V A, Koviazin, E E, Shchelokova, I A, Kostanian, S M, Dranitsyna, I I, Frolova, I I, Babichenko

Publikováno v: Arkhiv patologii. 69(3)

Antibodies to the factor HLDF are shown to be specific markers of apoptosis and permit the estimation of the rate of programmed cell death in the course of a normal menstrual cycle and in pathologic endometrial processes. HLDF expression in the epith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02cc7ecd19605a41a8ee95365fdcec87
https://pubmed.ncbi.nlm.nih.gov/17722590

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[Neuroprotective effect of the hexapeptide HLDF-6 on neurons of rat hippocampus on the model of Alzheimer's disease in vivo and in vitro]

Autor: I A, Kostanian, S S, Zhokhov, Z I, Storozheva, A T, Proshin, E A, Surina, I I, Babichenko, V V, Sherstnev, V M, Lipkin

Publikováno v: Bioorganicheskaia khimiia. 32(4)

The neuroprotective effect of Thr-Gly-Glu-Asn-His-Arg hexapeptide (HLDF-6), a biologically active fragment of the differentiation factor of human leukemia cells (HLDF), was demonstrated on models of Alzheimer's disease in vivo and in vitro. The syndr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42fc5e377bce7fd23b561765efc8b28e
https://pubmed.ncbi.nlm.nih.gov/16909864

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[Protein HLDF and antibodies to it as molecular pathogenetic factors and new markers of acute cerebral blood circulation disturbances]

Autor: V V, Sherstnev, V I, Skvortsova, M A, Gruden', E A, Shirokov, I S, Denshchuk, V V, Iurasov, E I, Elistratova, N E, Iakovleva, I M, Shetova, I A, Kostanian, O B, Gubskaia

Publikováno v: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. (Suppl 12)

Clinic-experimental complex investigation and ELISA determination of protein HLDF as also primary antibodies (Abs) to HLDF values in blood and cerebro-spinal fluid (CSF) of patients with hypertensive crises and acute aterotrombotic ischemic stroke we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1601c04327ca2cb2556b611cb615fd94
https://pubmed.ncbi.nlm.nih.gov/15628588

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[Precursors of HLDF differentiation factor and ribosomal protein RPS21 have a common N-terminal sequence]

Autor: E V, Smirnova, A V, Garkovenko, T V, Rakitina, S N, Berezhnoĭ, M V, Astapova, E A, Surina, I I, Babichenko, I A, Kostanian, V M, Lipkin

Publikováno v: Bioorganicheskaia khimiia. 30(2)

The mature differentiation factor HLDF, isolated from culture fluid, comprises 54 aa, whereas the open reading frame of mRNA encodes a 97-aa protein. We presumed that the protein translation begins from the first ATG codon, whose environment mostly m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4413ccfc193bf313835ebc0d059c0519
https://pubmed.ncbi.nlm.nih.gov/15143667

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[An artificial protein, possessing biological activity of HL-60 human promyelocytic leukemia differentiation factor]

Autor: R V, Chertkova, I A, Kostanian, M V, Astapova, E A, Surina, D A, Dolgikh, M P, Kirpichnikov

Publikováno v: Bioorganicheskaia khimiia. 29(1)

The ABB-df artificial protein was prepared by inserting the TGENHR biologically active peptide corresponding to the 41-46 sequence of the differentiation factor for the HL-60 cell line of the human promyelocyte leukemia into the N-terminus of the pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3587baaa274973fe1cb0674ca52d952e
https://pubmed.ncbi.nlm.nih.gov/12658990

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