Zobrazeno 1 - 10
of 11
pro vyhledávání: '"I A, Heyman"'
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 17(3)
A battery of mutagenicity tests was performed with nafarelin, an agonist analogue of luteinizing hormone releasing hormone (LHRH) containing tryptophan (Trp) and histidine (His). Included were the Ames assay and the gene conversion assay with yeast s
Autor:
I. Michael Heyman
Publikováno v:
Physics Today. 50:96-96
Publikováno v:
Drug and Chemical Toxicology. 5:401-414
Buflomedil was administered intravenously to rats at dosages of 1, 4, 12 or 30 mg/kg/day for up to three months. The no-adverse-effect dosage was considered to be 12 mg/kg/day. At 30 mg/kg/day several deaths and clinical signs, including ataxia, decr
Publikováno v:
Drug and Chemical Toxicology. 7:435-449
Terazosin, an alpha-adrenergic antagonist, was administered as a 15 mg/ml solution to rats intravenously at a rate of 2 ml/min. Under these conditions the LD50 was 277 mg/kg for males and 293 mg/kg for females. When administered daily for 1 month at
Autor:
F. L. FORT, M. C. PRATT, G. W. CARTER, J. P. LEWKOWSKI, I. A. HEYMAN, P. K. CUSICK, J. W. KESTERSON
Publikováno v:
Toxicological Sciences. 4:216-220
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 4(2 Pt 1)
Sprague-Dawley CD strain rats were given 18, 35, 70, or 140 mg/kg/day of 3-amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline by gavage for 2 weeks. Heinz bodies were seen in the erythrocytes of rats given 140 mg/kg/day. Dose-related increases in methe
Autor:
U, Schaeppi, R, Phelan, S W, Stadnicki, R W, Fleischman, I A, Heyman, V, Ilievski, R A, Redding
Publikováno v:
Cancer chemotherapy reports. 58(3)
Publikováno v:
Journal of parenteral science and technology : a publication of the Parenteral Drug Association. 38(2)
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 4(5)
A comparative toxicity and carcinogenicity study was carried out for 2 years with estazolam, a benzodiazepine, via diet in Sprague-Dawley rats (0.5, 2, and 10 mg/kg/day) and in B6C3F1 mice (0.8, 3, and 10 mg/kg/day). In rats, no biologically signific