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The Gastroprotective Effects of Anisomeles indica against Ethanol-Induced Gastric Ulcer through the Induction of IκB-α and the Inhibition of NF-κB Expression

Autor: Yu-Ru Chen, Hsiu-Man Lien, Fuu-Jen Tsai, Jiunn-Wang Liao, Yng-Tay Chen

Publikováno v: Nutrients, Vol 16, Iss 14, p 2297 (2024)

Anisomeles indica (L.) Kuntze is a traditional herb with multiple medicinal properties and with potential for preventing or treating various diseases. Acteoside, one of the active ingredients in A. indica, is prepared into commercially available prod

Externí odkaz: https://doaj.org/article/4edcf5b28ee34e87ba01a47d6807724e

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Expression of plasma nuclear factor-kappa B cells (NF-κB) and Inhibitory subunit kappa B alpha (IκB-α) in HIV-associated pre-eclampsia

Autor: Bambanani Zozo, Nalini Govender, Jagidesa Moodley, Thajasvarie Naicker

Publikováno v: Hypertension in Pregnancy, Vol 40, Iss 1, Pp 15-20 (2021)

Objective:To investigate the expression of plasma NF-κB and the inhibitory subunit IκB-α in HIV-associated pre-eclampsia. Method: This retrospective study examined plasma NF-κB and IκB-α expression expressed as Mean Fluorescence Intensity (MFI)

Externí odkaz: https://doaj.org/article/f6b77504720947378c59fdda85465d8c

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(5R)-5-hydroxytriptolide inhibits the inflammatory cascade reaction in astrocytes

Autor: Yan-Qiu Cui, Yan Zheng, Gui-Lian Tan, Dong-Mei Zhang, Jun-Ya Wang, Xiao-Min Wang

Publikováno v: Neural Regeneration Research, Vol 14, Iss 5, Pp 913-920 (2019)

Many studies have shown that (5R)-5-hydroxytriptolide is the optimal modified analogue of triptolide, possessing comparable immunosuppressive activity but much lower cytotoxicity than triptolide. Whether (5R)-5-hydroxytriptolide has preventive effect

Externí odkaz: https://doaj.org/article/f2aac297e431473694642f8336862173

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Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Autor: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)

Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020

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PPARα Agonist Suppresses Inflammation after Corneal Alkali Burn by Suppressing Proinflammatory Cytokines, MCP-1, and Nuclear Translocation of NF-κB

Autor: Yuichiro Nakano, Masaaki Uchiyama, Takeshi Arima, Shinya Nagasaka, Tsutomu Igarashi, Akira Shimizu, Hiroshi Takahashi

Publikováno v: Molecules, Vol 24, Iss 1, p 114 (2018)

We investigated the effect of a peroxisome proliferator-activated receptor α (PPARα) agonist after corneal alkali injury. Fenofibrate 0.05% (PPARα agonist group) or vehicle (Vehicle group) was topically instilled onto the rat cornea after injury.

Externí odkaz: https://doaj.org/article/2218edfb62144b11bfe779ddc9438d41

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Akademický článek

Review: NF-κB pathways in the pathogenesis of Multiple Sclerosis and the therapeutic implications

Autor: Saskia Michaela Leibowitz, Jun Yan

Publikováno v: Frontiers in Molecular Neuroscience, Vol 9 (2016)

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling pathways are involved in cell immune responses, apoptosis and infections. In Multiple Sclerosis (MS), NF-κB pathways are changed, leading to increased levels of NF-κ

Externí odkaz: https://doaj.org/article/df36a63142fd40e38519e1ab36ad6974

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Chronic treatment with agents that stabilize cytosolic IκB-α enhances survival and improves resting membrane potential in MDX muscle fibers subjected to chronic passive stretch

Autor: C. George Carlson, Abbas Samadi, Ashley Siegel

Publikováno v: Neurobiology of Disease, Vol 20, Iss 3, Pp 719-730 (2005)

The potential pathogenic role of increased NFκB signaling in passively stretched dystrophic skeletal muscle was examined by treating adult mdx mice with an agent that stabilized cytosolic IκB-α (pyrollidine dithiocarbamate, PDTC)and examining the

Externí odkaz: https://doaj.org/article/ba0f9ad84e5f41aba359bac8cec5838e

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