Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Iñigo Ayestaran"'
Autor:
Iñigo Ayestaran, Ana Galhoz, Elmar Spiegel, Ben Sidders, Jonathan R. Dry, Frank Dondelinger, Andreas Bender, Ultan McDermott, Francesco Iorio, Michael P. Menden
Publikováno v:
Patterns, Vol 1, Iss 5, Pp 100065- (2020)
Summary: High-throughput drug screens in cancer cell lines test compounds at low concentrations, thereby enabling the identification of drug-sensitivity biomarkers, while resistance biomarkers remain underexplored. Dissecting meaningful drug response
Externí odkaz:
https://doaj.org/article/d82a772631b143af81594c8c2fa667a7
Autor:
Iñigo Ayestaran, Jamie R. Blundell
T-cell receptor (TCR) repertoires provide a historical record of antigen exposure. However, the dynamics of TCR repertoires in healthy individuals remain largely uncharacterised. How much of the repertoire is under immune selection in healthy individ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e3f52afb309868da385186bf10081ed
https://doi.org/10.1101/2022.05.11.491566
https://doi.org/10.1101/2022.05.11.491566
Autor:
Mark J. O'Connor, Yaron Galanty, Josep V. Forment, Rebecca L. Lloyd, Stephen P. Jackson, Christelle de Renty, Iñigo Ayestaran, John Christopher Thomas, Vaclav Urban, Francisco Muñoz-Martínez
Publikováno v:
Nucleic Acids Research
The protein kinase ATR plays pivotal roles in DNA repair, cell cycle checkpoint engagement and DNA replication. Consequently, ATR inhibitors (ATRi) are in clinical development for the treatment of cancers, including tumours harbouring mutations in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43824e60f652bcb0b0fd6b3802216e2
Autor:
Alexandra Selivanova, Rong Li, Roded Sharan, Shir Klein-Lavi, Mareike Herzog, Jin Zhu, Iñigo Ayestaran, Israel Salguero, Stephen P. Jackson, Siyue Wang, Martin Kupiec, Roi Meirman, Molly Gordon, Gonzalo Millán-Zambrano, Fabio Puddu
Publikováno v:
Nature. 573:416-420
Despite major progress in defining the functional roles of genes, a complete understanding of their influences is far from being realized, even in relatively simple organisms. A major milestone in this direction arose via the completion of the yeast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::090eae16b2265900cde70e616889149e
https://doi.org/10.1038/s41586-019-1549-9
https://doi.org/10.1038/s41586-019-1549-9
Autor:
Francesco Iorio, Michael P. Menden, Ben Sidders, Andreas Bender, Ultan McDermott, Jonathan R. Dry, Iñigo Ayestaran
Publikováno v:
SSRN Electronic Journal.
Precision medicine is empowered by biomarker discovery. High-throughput drug screens in cancer cell lines enable the identification of drug sensitivity biomarkers, whilst resistance biomarkers remain underexplored: dissecting meaningful drug response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa4f73bd5fe08b112f03ab1db800cf3
https://doi.org/10.2139/ssrn.3565985
https://doi.org/10.2139/ssrn.3565985