Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Iñaki Eguren"'
Autor:
Pedro Berraondo, Ignacio Melero, Miguel F Sanmamed, Carlos E De Andrea, María Campos, Iñaki Eguren-Santamaria, Eva Fernández de Piérola, Gracián Camps, Paula Martín-Muñoz, Doina Cuculescu, Inmaculada Aguilera-Buenosvinos, Inmaculada Rodríguez López, Rafael Salido-Vallejo, Raluca Alexandru, Laura Álvarez-Gigli
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 9 (2024)
Background Immunodeficient mice engrafted with peripheral blood mononuclear cells (PBMCs) are models to study new cancer immunotherapy agents. However, this approach is associated with xenograft-versus-host disease (xGVHD), which starts early after P
Externí odkaz:
https://doaj.org/article/bf82f9c0cbf94be6a1a8d4e73fac748e
Autor:
Iñaki Eguren-Santamaría, Inmaculada Rodríguez, Claudia Herrero-Martin, Eva Fernández de Piérola, Arantza Azpilikueta, Sandra Sánchez-Gregorio, Elixabet Bolaños, Gabriel Gomis, Paula Molero-Glez, Enrique Chacón, José Ángel Mínguez, Santiago Chiva, Fernando Diez-Caballero, Carlos de Andrea, Álvaro Teijeira, Miguel F. Sanmamed, Ignacio Melero
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Biomarkers for cancer immunotherapy are an unmet medical need. The group of Daniela Thommen at the NKI recently reported on novel methodologies based on short-term cultures of patient-derived tumor fragments whose cytokine concentrations in the super
Externí odkaz:
https://doaj.org/article/09779cffd119438d95ea60cb833a5d60
Autor:
Assunta Cirella, Elixabet Bolaños, Carlos Luri-Rey, Claudia Augusta Di Trani, Irene Olivera, Gabriel Gomis, Javier Glez-Vaz, Beatrice Pinci, Saray Garasa, Sandra Sánchez-Gregorio, Arantza Azpilikueta, Iñaki Eguren-Santamaria, Karmele Valencia, Belén Palencia, Maite Alvarez, Maria C. Ochoa, Álvaro Teijeira, Pedro Berraondo, Ignacio Melero
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 668-682 (2023)
Intratumoral immunotherapy strategies for cancer based on interleukin-12 (IL-12)-encoding cDNA and mRNA are under clinical development in combination with anti-PD-(L)1 monoclonal antibodies. To make the most of these approaches, we have constructed c
Externí odkaz:
https://doaj.org/article/0cbeb48e82c4432eb1d5f41226df6231
Autor:
Laura Hato, Angel Vizcay, Iñaki Eguren, José L. Pérez-Gracia, Javier Rodríguez, Jaime Gállego Pérez-Larraya, Pablo Sarobe, Susana Inogés, Ascensión López Díaz de Cerio, Marta Santisteban
Publikováno v:
Cancers, Vol 16, Iss 5, p 981 (2024)
Cancer immunotherapy modulates the immune system, overcomes immune escape and stimulates immune defenses against tumors. Dendritic cells (DCs) are professional promoters of immune responses against tumor antigens with the outstanding ability to coord
Externí odkaz:
https://doaj.org/article/7f9caae95de54443a5ef418551895a3b
Autor:
Arantza Azpilikueta, Ignacio Melero, Sonia Guedan, Alvaro Teijeira, Lieping Chen, Maria C Ochoa, Maite Alvarez, Jose Luis Perez Gracia, Maria E Rodriguez-Ruiz, Miguel F Sanmamed, Assunta Cirella, Javier Glez-Vaz, Irene Olivera, Iñaki Eguren-Santamaria, Carlos Luri-Rey, Xinxin Nie
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background On the basis of efficacy in mouse tumor models, multiple CD137 (4-1BB) agonist agents are being preclinically and clinically developed. The costimulatory molecule CD137 is inducibly expressed as a transmembrane or as a soluble protein (sCD
Externí odkaz:
https://doaj.org/article/73397a239a8744e29c59d4accc19c284
Autor:
Assunta Cirella, Elixabet Bolaños, Claudia Augusta Di Trani, Carlos E. de Andrea, Sandra Sánchez-Gregorio, Iñaki Etxeberria, Jose Gonzalez-Gomariz, Irene Olivera, Davide Brocco, Javier Glez-Vaz, Carlos Luri-Rey, Arantza Azpilikueta, Inmaculada Rodríguez, Myriam Fernandez-Sendín, Josune Egea, Iñaki Eguren, Miguel F. Sanmamed, Belen Palencia, Alvaro Teijeira, Pedro Berraondo, Ignacio Melero
Publikováno v:
Cancer Immunology Research. 11:184-198
IL12-based local gene therapy of cancer constitutes an active area of clinical research using plasmids, mRNAs, and viral vectors. To improve antitumor effects, we have experimentally tested the combination of mRNA constructs encoding IL12 and IL18. M
Autor:
Ignacio Melero, Álvaro Teijeira, Frances R. Balkwill, Pedro Berraondo, Carlos E. de Andrea, David Propper, Beatrice Malacrida, María C. Ochoa, Maite Alvarez, Arantza Azpilikueta, Javier Glez-Vaz, Miguel F. Sanmamed, Iñaki Eguren-Santamaria, Itziar Migueliz, Saray Garasa, Josune Egea, Assunta Cirella, Iñaki Etxeberria, Inmaculada Rodriguez, Elixabet Bolaños, Rebeca Sanz-Pamplona, Irene Olivera
Supplementary Figure from A Therapeutically Actionable Protumoral Axis of Cytokines Involving IL-8, TNFα, and IL-1β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f32d8b6c5cd605ff447850ccc7e59f0
https://doi.org/10.1158/2159-8290.22541500.v1
https://doi.org/10.1158/2159-8290.22541500.v1
Autor:
Ignacio Melero, Pedro Berraondo, Alvaro Teijeira, Belen Palencia, Miguel F. Sanmamed, Iñaki Eguren, Josune Egea, Myriam Fernandez-Sendín, Inmaculada Rodríguez, Arantza Azpilikueta, Carlos Luri-Rey, Javier Glez-Vaz, Davide Brocco, Irene Olivera, Jose Gonzalez-Gomariz, Iñaki Etxeberria, Sandra Sánchez-Gregorio, Carlos E. de Andrea, Claudia Augusta Di Trani, Elixabet Bolaños, Assunta Cirella
Supplementary figures 1-8 and supplementary table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55de1d63f2018b5b1f25ddd31b7fe707
https://doi.org/10.1158/2326-6066.22546073
https://doi.org/10.1158/2326-6066.22546073
Autor:
Ignacio Melero, Pedro Berraondo, Alvaro Teijeira, Belen Palencia, Miguel F. Sanmamed, Iñaki Eguren, Josune Egea, Myriam Fernandez-Sendín, Inmaculada Rodríguez, Arantza Azpilikueta, Carlos Luri-Rey, Javier Glez-Vaz, Davide Brocco, Irene Olivera, Jose Gonzalez-Gomariz, Iñaki Etxeberria, Sandra Sánchez-Gregorio, Carlos E. de Andrea, Claudia Augusta Di Trani, Elixabet Bolaños, Assunta Cirella
IL12-based local gene therapy of cancer constitutes an active area of clinical research using plasmids, mRNAs, and viral vectors. To improve antitumor effects, we have experimentally tested the combination of mRNA constructs encoding IL12 and IL18. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437f9c251748ad1ccee76718bd3f677d
https://doi.org/10.1158/2326-6066.c.6551084
https://doi.org/10.1158/2326-6066.c.6551084
Autor:
Ignacio Melero, Álvaro Teijeira, Frances R. Balkwill, Pedro Berraondo, Carlos E. de Andrea, David Propper, Beatrice Malacrida, María C. Ochoa, Maite Alvarez, Arantza Azpilikueta, Javier Glez-Vaz, Miguel F. Sanmamed, Iñaki Eguren-Santamaria, Itziar Migueliz, Saray Garasa, Josune Egea, Assunta Cirella, Iñaki Etxeberria, Inmaculada Rodriguez, Elixabet Bolaños, Rebeca Sanz-Pamplona, Irene Olivera
Interleukin-8 (CXCL8) produced in the tumor microenvironment correlates with poor response to checkpoint inhibitors and is known to chemoattract and activate immunosuppressive myeloid leukocytes. In human cancer, IL8 mRNA levels correlate with IL1B a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968f3422d851bd514a8234d09869527b
https://doi.org/10.1158/2159-8290.c.6549661
https://doi.org/10.1158/2159-8290.c.6549661