Zobrazeno 1 - 10
of 157
pro vyhledávání: '"I, van Wijngaarden"'
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 112:126-130
Medicinal chemists have provided crucial tools for the identification and characterization of various subtypes of serotonin (5-hydroxytryptamine, 5-HT) receptors. At present, potent and selective (ratio ≥ 100) ligands have been developed for the 5-
Autor:
I van Wijngaarden, W. Soudijn
Publikováno v:
Current Medicinal Chemistry. 7:1063-1079
GABA is the major inhibitory neurotransmitter in the brain and GABA re- uptake from the synaptic cleft is one important mechanism in the regulation of GABA activity. Inhibition of the re-uptake of GABA by potent and selective inhibitors of the GABA t
Publikováno v:
ChemInform. 22
On the basis of a model we recently developed for the antagonist binding site of the adenosine A1 receptor (J. Med. Chem. 1990, 33, 1708-1713), it was predicted that 1H-imidazo[4,5-c]quinolin-4-amines would be antagonists of the A1 receptor. Furtherm
Publikováno v:
ChemInform. 24
Medicinal chemists have provided crucial tools for the identification and characterization of various subtypes of serotonin (5-hydroxytryptamine, 5-HT) receptors. At present, potent and selective (ratio ≥ 100) ligands have been developed for the 5-
Publikováno v:
ChemInform. 27
Publikováno v:
ChemInform. 30
Autor:
W. Soudijn, P. Nissen, I. Van Wijngaarden, Th. H. W. Van Vlijmen, P. J. M. Van Galen, A. P. Ljzerman
Publikováno v:
Nucleosides and Nucleotides. 10:1039-1047
With the aid of molecular modelling both adenosine and adenosine A, receptor antagonists belonging to various chemical classes were compared. A model for the antagonist binding site was developed. As a consequence 1H-imidazo[4, 5-c]-quinolin-4-amines
Publikováno v:
Journal of Medicinal Chemistry. 34:1202-1206
On the basis of a model we recently developed for the antagonist binding site of the adenosine A1 receptor (J. Med. Chem. 1990, 33, 1708-1713), it was predicted that 1H-imidazo[4,5-c]quinolin-4-amines would be antagonists of the A1 receptor. Furtherm
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 54
An overview is presented on progress made in the research on neuronal transporters of serotonin, dopamine and norepinephrine in the central nervous system. Tools developed by molecular biology, such as expression of cloned transporters, their mutants
Publikováno v:
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. 52
An overview is presented on progress made in research on 5-HT1A receptors and their ligands since their discovery in 1983. Molecular biology has offered new tools, for example cloned 5-HT1A receptors, their mutants and chimeras to study structure and