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Publikováno v:
Die Pharmazie. 49(5)
The study presents the results of our efforts to prepare liposomes with high lung uptake by modifying the liposome composition and size. Multilamellar liposomes composed of soya phosphatidylcholine and cholesterol (molar ratio 1:1), negatively charge
Publikováno v:
The Journal of pharmacy and pharmacology. 45(8)
The disappearance kinetics of the acetylcholinesterase inhibitor galanthamine hydrobromide from the gastrointestinal tract of male Wistar rats, 200–250 g, in-situ has been examined. After 30 min the galanthamine loss was 16% in the stomach (pH 2),
Publikováno v:
Die Pharmazie. 47(4)
The oil to water partition behaviour, the diffusion across artificial lipid barriers and the in situ gastro-intestinal absorption of the haemostatic etamsylate were studied. Very small partition coefficients were obtained (0.015-0.13) which are indep
Publikováno v:
Die Pharmazie. 47(3)
Autor:
B. Descours, Philippe Devillier, J. Boada, Domenico Regoli, George B. Corcoran, Raymond E. Galinsky, S.A. Rodriguez-Mendez, Darrell.B. Abernethy, Janice B. Schwartz, A. Asseraf, I. Yamboliev, M.W.L. Koo, Jerry R. Mitchell, Elizabeth L. Todd, C.H. Cho, D. Mihailova, Hans-Hasso Frey, J. Marsac, M. Feria, M. Renoux, C.W. Ogle
Publikováno v:
Pharmacology. 32:I-V
Publikováno v:
Pharmacology. 39:50-58
Galanthamine hydrobromide (Nivalin, dose 10 mg) was given subcutaneously and orally to 8 volunteers. Galanthamine and its metabolites were quantified in plasma and urine by reversed-phase HPLC. An unusual two-stage absorption and biexponential drug d
Autor:
D. Mihailova, I. Yamboliev
Publikováno v:
Pharmacology. 32:301-306
A study on galanthamine hydrobromide (Nivalin) pharmacokinetics was carried out on male Wistar rats following single intravenous and oral administration. Plasma samples were collected after decapitation of the animals. The drug concentrations were de
Publikováno v:
Die Pharmazie. 40(6)
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 7(11)
The pharmacokinetic behaviour of nivalin (galanthamine hydrobromide) and its effect on the contractile response of electrically stimulated m. tibialis anterior were simultaneously studied after an i.v. administered dose of 3 mg/kg in cats. The determ