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Autor:
I, Torrini, M, Paglialunga Paradisi, G, Pagani Zecchini, G, Lucente, G, Mastropietro, S, Spisani
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 55(2)
In order to obtain chemotactic peptides with selective bioactivity, a new type of structural modification was introduced at the N-terminal position of HCO-Nle-Leu-Phe-OMe. Two groups of analogs have been synthesized both containing a N-terminal resid
Autor:
E, Fabbri, S, Spisani, C, Biondi, L, Barbin, M L, Colamussi, A, Cariani, S, Traniello, I, Torrini, M E, Ferretti
Publikováno v:
Biochimica et biophysica acta. 1359(3)
For-Thp-Leu-Ain-OMe and for-Met-delta(z)Leu-Phe-OMe are two conformationally restricted fMLP-OMe analogues able to discriminate between different biological responses of human neutrophils. In this paper, we demonstrate that the former peptide, which
Autor:
I, Torrini, M, Paglialunga Paradisi, G, Pagani Zecchini, G, Lucente, E, Gavuzzo, F, Mazza, G, Pochetti, S, Traniello, S, Spisani
Publikováno v:
Biopolymers. 42(4)
The new C alpha-tetrasubstituted alpha-amino acid residue 2-[2'-(methylthio)ethyl]methionine (Dmt) has been introduced into the reference chemotactic tripeptide HCO-Met-Leu-Phe-OMe (fMLP-OMe) in place of the leucine or methionine, respectively. The b
Autor:
I, Torrini, G, Pagani Zecchini, M, Paglialunga Paradisi, G, Lucente, G, Mastropietro, E, Gavuzzo, F, Mazza, G, Pochetti, S, Traniello, S, Spisani
Publikováno v:
Biopolymers. 39(3)
HCO-Thp-Ac6c-Phe-OMe (3) has been synthesized as a new analogue of the prototypical chemotactic agent HCO-Met-Leu-Phe-OMe (fMLP-OMe). Compound 3 contains 4-aminotetra-hydrothiopyran-4-carboxylic acid (Thp) and 1-aminocyclohexane-1-carboxylic acid (Ac
Publikováno v:
Archiv der Pharmazie. 329(3)
Several formylpeptides, analogs of the chemotactic agent HCO-Met-Leu-Phe-OMe, having the HCO-Xaa-Leu-delta ZPhe-OMe and HCO-Xaa-Leu-delta ZPhe-Phe-OMe structures (delta ZPhe = (Z)-2,3-didehydrophenylalanine), have been synthesized. The biological act
Publikováno v:
Farmaco (Societa chimica italiana : 1989). 40(11)
For-Met-delta ZLeu-delta ZPhe-OMe (3) has been synthesized as a new analogue of the prototypical chemotactic agent For-Met-Leu-Phe-OMe (fMLP-OMe). Compound 3 is characterized by presence of two consecutive alpha,beta-didehydro amino acid residues [de
Autor:
S, Spisani, S, Traniello, A L, Giuliani, I, Torrini, G, Pagani Zecchini, M, Paglialunga Paradisi, E, Gavuzzo, F, Mazza, G, Pochetti, G, Lucente
Publikováno v:
Biochemistry international. 26(6)
As a part of a research programme aimed at studying structure activity relationships in the field of chemotactic peptides, modified analogs of the chemoattractant N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) were examined for their capacity t
Autor:
I, Torrini, G, Pagani Zecchini, M, Paglialunga Paradisi, G, Lucente, E, Gavuzzo, F, Mazza, G, Pochetti, S, Spisani, A L, Giuliani
Publikováno v:
International journal of peptide and protein research. 38(6)
As a part of a research program aimed at studying structure activity relationship in the field of chemotactic peptides, modified analogs of the potent chemoattractant HCO-Met-Leu-Phe-OH (fMLP) of the general formula HCO-Xaa-Leu-Yaa-OMe are examined.