Zobrazeno 1 - 10
of 94
pro vyhledávání: '"I, Serysheva"'
Autor:
Koki Mise, Jianyin Long, Daniel L. Galvan, Zengchun Ye, Guizhen Fan, Rajesh Sharma, Irina I. Serysheva, Travis I. Moore, Collene R. Jeter, M. Anna Zal, Motoo Araki, Jun Wada, Paul T. Schumacker, Benny H. Chang, Farhad R. Danesh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The mitochondrial electron transport chain (ETC) is a highly adaptive process to meet metabolic demands of the cell, and its dysregulation has been associated with diverse clinical pathologies. However, the role and nature of impaired ETC in
Externí odkaz:
https://doaj.org/article/453171ce7f1542cba93f5b45df627a2b
Autor:
Corey F. Hryc, Venkata K. P. S. Mallampalli, Evgeniy I. Bovshik, Stavros Azinas, Guizhen Fan, Irina I. Serysheva, Genevieve C. Sparagna, Matthew L. Baker, Eugenia Mileykovskaya, William Dowhan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory supercomplex organization, a mechanistic understanding of this lipid-protein interaction is still la
Externí odkaz:
https://doaj.org/article/430024e2f27b454daa8194066be71738
Autor:
Koki Mise, Jianyin Long, Daniel L. Galvan, Zengchun Ye, Guizhen Fan, Rajesh Sharma, Irina I. Serysheva, Travis I. Moore, Collene R. Jeter, M. Anna Zal, Motoo Araki, Jun Wada, Paul T. Schumacker, Benny H. Chang, Farhad R. Danesh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/c4f100e58c874f5c8dae224ec3a84966
Autor:
Guizhen Fan, Mariah R. Baker, Lara E. Terry, Vikas Arige, Muyuan Chen, Alexander B. Seryshev, Matthew L. Baker, Steven J. Ludtke, David I. Yule, Irina I. Serysheva
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here authors report cryo-EM structures of IP3R1 which provide atomic details of IP3, Ca2+ and ATP binding. Molecular motions of key domains and sidechains were found to regulate ligand binding and gating, which are validated by functional assays.
Externí odkaz:
https://doaj.org/article/19978619640c40e4bd70b573581c08b9
Autor:
Mariah R. Baker, Guizhen Fan, Alexander B. Seryshev, Melina A. Agosto, Matthew L. Baker, Irina I. Serysheva
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
3D structure of full-length rat type 1 inositol 1,4,5-trisphosphate receptor reconstituted in lipid nanodisc is determined using single-particle cryo-electron microscopy. The study suggests conserved locations of protein-bound lipids among structural
Externí odkaz:
https://doaj.org/article/10329eb0880f42febb3dead68ecf9485
Autor:
Vikas Arige, Lara E. Terry, Larry E. Wagner, Sundeep Malik, Mariah R. Baker, Guizhen Fan, Suresh K. Joseph, Irina I. Serysheva, David I. Yule
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(39)
Inositol 1,4,5-trisphosphate receptors (IP 3 Rs) initiate a diverse array of physiological responses by carefully orchestrating intracellular calcium (Ca 2+ ) signals in response to various external cues. Notably, IP 3 R channel activity is determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83a84948f9f1a6930e23fa1d0493d78
https://pubmed.ncbi.nlm.nih.gov/36215521
https://pubmed.ncbi.nlm.nih.gov/36215521
Publikováno v:
European Journal of Translational Myology, Vol 25, Iss 1, Pp 35-48 (2015)
Ryanodine receptors (RyRs) are tetrameric ligand-gated Ca2+ release channels that are responsible for the increase of cytosolic Ca2+ concentration leading to muscle contraction. Our current understanding of RyR channel gating and regulation is greatl
Externí odkaz:
https://doaj.org/article/9329207d50bc4148a9e1c979d19cb560
Autor:
Zhao Wang, Guizhen Fan, Corey F Hryc, James N Blaza, Irina I Serysheva, Michael F Schmid, Wah Chiu, Ben F Luisi, Dijun Du
Publikováno v:
eLife, Vol 6 (2017)
Bacterial efflux pumps confer multidrug resistance by transporting diverse antibiotics from the cell. In Gram-negative bacteria, some of these pumps form multi-protein assemblies that span the cell envelope. Here, we report the near-atomic resolution
Externí odkaz:
https://doaj.org/article/714d43d2f1284de5b3691b0f864d7a20
Autor:
Guizhen Fan, Mariah R. Baker, Lara E. Terry, Vikas Arige, Muyuan Chen, Alexander B. Seryshev, Matthew L. Baker, Steven J. Ludtke, David I. Yule, Irina I. Serysheva
Inositol-1,4,5-trisphosphate receptors (IP3Rs) are activated by IP3 and Ca2+ and their gating is regulated by various intracellular messengers that finely tune the channel activity. Here, using single particle cryo-EM analysis we determined 3D struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac020b81808b0a7919b5bffd9befaf0b
https://doi.org/10.1101/2022.05.27.493711
https://doi.org/10.1101/2022.05.27.493711
Autor:
Julika, Neumann, Erika, Van Nieuwenhove, Lara E, Terry, Frederik, Staels, Taylor R, Knebel, Kirsten, Welkenhuyzen, Kourosh, Ahmadzadeh, Mariah R, Baker, Margaux, Gerbaux, Mathijs, Willemsen, John S, Barber, Irina I, Serysheva, Liesbeth, De Waele, François, Vermeulen, Susan, Schlenner, Isabelle, Meyts, David I, Yule, Geert, Bultynck, Rik, Schrijvers, Stephanie, Humblet-Baron, Adrian, Liston
Publikováno v:
Cellularmolecular immunology. 20(1)
Calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-operated calcium (Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a9b817d4ec9720078c53264530ac877
https://pubmed.ncbi.nlm.nih.gov/36471115
https://pubmed.ncbi.nlm.nih.gov/36471115