Zobrazeno 1 - 10
of 931
pro vyhledávání: '"I, Morimoto"'
Autor:
Akira Kitamura, Ai Fujimoto, Rei Kawashima, Yidan Lyu, Kotetsu Sasaki, Yuta Hamada, Kanami Moriya, Ayumi Kurata, Kazuho Takahashi, Reneé Brielmann, Laura C. Bott, Richard I. Morimoto, Masataka Kinjo
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-21 (2024)
Abstract Carboxy terminal fragments (CTFs) of TDP-43 contain an intrinsically disordered region (IDR) and form cytoplasmic condensates containing amyloid fibrils. Such condensates are toxic and associated with pathogenicity in amyotrophic lateral scl
Externí odkaz:
https://doaj.org/article/edf11e8a7f974a75b2d3e0e0a54b502f
Autor:
Pathum M. Weerawarna, Isaac T. Schiefer, Pedro Soares, Susan Fox, Richard I. Morimoto, Rafael D. Melani, Neil L. Kelleher, Chi-Hao Luan, Richard B. Silverman
Publikováno v:
ACS Central Science, Vol 10, Iss 1, Pp 87-103 (2023)
Externí odkaz:
https://doaj.org/article/ba3032efe9234196b66de6d2dfb01321
Autor:
Prajwal Ciryam, Matthew Antalek, Fernando Cid, Gian Gaetano Tartaglia, Christopher M. Dobson, Anne-Katrin Guettsches, Britta Eggers, Matthias Vorgerd, Katrin Marcus, Rudolf A. Kley, Richard I. Morimoto, Michele Vendruscolo, Conrad C. Weihl
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract Protein aggregation is a pathological feature of neurodegenerative disorders. We previously demonstrated that protein inclusions in the brain are composed of supersaturated proteins, which are abundant and aggregation-prone, and form a metas
Externí odkaz:
https://doaj.org/article/98b5bb1d9beb43de9d33f052fb29e0d6
Autor:
Thomas Stoeger, Rogan A. Grant, Alexandra C. McQuattie-Pimentel, Kishore R. Anekalla, Sophia S. Liu, Heliodoro Tejedor-Navarro, Benjamin D. Singer, Hiam Abdala-Valencia, Michael Schwake, Marie-Pier Tetreault, Harris Perlman, William E. Balch, Navdeep S. Chandel, Karen M. Ridge, Jacob I. Sznajder, Richard I. Morimoto, Alexander V. Misharin, G. R. Scott Budinger, Luis A. Nunes Amaral
Publikováno v:
Nature Aging. 2:1191-1206
Aging is among the most important risk factors for morbidity and mortality. To contribute toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data from multiple studies. Here, we show that transcript length alone explai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0de44d4d63fdc5bb0ddd8d07ad5d272
https://doi.org/10.1038/s43587-022-00317-6
https://doi.org/10.1038/s43587-022-00317-6
Autor:
Johnathan Labbadia, Renee M. Brielmann, Mario F. Neto, Yi-Fan Lin, Cole M. Haynes, Richard I. Morimoto
Publikováno v:
Cell Reports, Vol 21, Iss 6, Pp 1481-1494 (2017)
Summary: In Caenorhabditis elegans, the programmed repression of the heat shock response (HSR) accompanies the transition to reproductive maturity, leaving cells vulnerable to environmental stress and protein aggregation with age. To identify the fac
Externí odkaz:
https://doaj.org/article/7c5dd2b3a2014fc6a1d3dc2c7ac4051e
Publikováno v:
PLoS Biology, Vol 16, Iss 12, p e3000075 (2018)
In this Formal Comment, the authors of the recent publication "Large-scale investigation of the reasons why potentially important genes are ignored" maintain that it can be read as an opportunity to explore the unknown.
Externí odkaz:
https://doaj.org/article/ec71c9df5ea440ee857ec180114f18a2
Autor:
Ambre J. Sala, Rogan A. Grant, Ghania Imran, Claire Morton, Renee M. Brielmann, Laura C. Bott, Jennifer Watts, Richard I. Morimoto
The ability to sense and respond to proteotoxic insults declines with age, leaving cells vulnerable to chronic and acute stressors. Reproductive cues modulate this decline in cellular proteostasis to influence organismal stress resilience inC. elegan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abb8aaa76c9f520b2b940b5c37c40346
https://doi.org/10.1101/2023.04.25.537803
https://doi.org/10.1101/2023.04.25.537803
Autor:
Ambre Sala, Richard I. Morimoto
Publikováno v:
Trends Cell Biol
The proteostasis network (PN) regulates protein synthesis, folding, and degradation, and is critical for the health and function of all cells. The PN has been extensively studied in the context of aging and age-related diseases, and loss of proteosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328a03c2d24cdccc4bb5023d7f58d2e4
https://pubmed.ncbi.nlm.nih.gov/34654604
https://pubmed.ncbi.nlm.nih.gov/34654604
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2006643 (2018)
Biomedical research has been previously reported to primarily focus on a minority of all known genes. Here, we demonstrate that these differences in attention can be explained, to a large extent, exclusively from a small set of identifiable chemical,
Externí odkaz:
https://doaj.org/article/bb0c33ad604f4c2da4367836eb132b52
Autor:
Leonard Yoon, Rachel C. Botham, Adriaan Verhelle, Pablo Sanz-Martinez, Jin Xu, Christian M. Cole, Ee Phie Tan, Ching Chieh Chou, Caroline A. Cuoco, Lynée A. Massey, Sergio Labra, Lisa P. Elia, Amina Ta, Maziar S. Ardejani, Kyunga Lee, Gabriel M. Kline, Qiang Xiao, Sara Cano-Franco, Nora J. Lyang, William C. Hou, Anan Yu, Susan Fox, Yeonjin Ko, Cristian Wulkop-Gil, Lara H. Ibrahim, Starr Jiang, Alina Meneses, Luke T. Nelson, Hongfan Peng, Stuart A. Lipton, Michael J. Bollong, Malene Hansen, Richard I. Morimoto, H. Michael Petrassi, R. Luke Wiseman, Evan T. Powers, Steven Finkbeiner, Danny Garza, Daniel Finley, Miguel A. Prado, Ivan Dikic, Judith Frydman, Kristen A. Johnson, M. Catarina Silva, Stephen J. Haggarty, Alexandra Stolz, Sandra E. Encalada, Jeffery W. Kelly
SummaryAutophagy activation has the potential to ameliorate neurodegenerative disease phenotypes, including protein aggregation, lipid level perturbations and axonal trafficking defects. We performed a high content imaging-based screen assessing 940,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e6dc4b0e683bc6167610911ea432da2
https://doi.org/10.1101/2022.09.29.509997
https://doi.org/10.1101/2022.09.29.509997