Zobrazeno 1 - 10
of 737
pro vyhledávání: '"I, Kramer"'
Genetic Testing for Familial Hypercholesterolemia: The Current State of Its Implementation in Canada
Autor:
Adam I. Kramer, MD, MSc, Susan Christian, MSc, PhD, Kirsten Bartels, MSc, Nicol Vaizman, BS, Robert A. Hegele, MD, Liam R. Brunham, MD, PhD
Publikováno v:
CJC Open, Vol 6, Iss 11, Pp 1395-1402 (2024)
Background: Familial hypercholesterolemia (FH) is a common genetic disorder, yet it remains largely underdiagnosed in Canada. Multiple national and international guidelines recommend the use of clinical genetic testing for FH. However, the level of i
Externí odkaz:
https://doaj.org/article/f49f497e8c9a4d53994a602c3b7ba285
Autor:
Bloch, Sherri, Lévêque, Laura, Hertz-Picciotto, Irva, Puschner, Birgit, Fritsche, Ellen, Klose, Jördis, I. Kramer, Nynke, Bouchard, Maryse F., Chandrasekera, P. Charukeshi, Verner, Marc-André
Publikováno v:
In Environment International January 2024 183
Autor:
Sherri Bloch, Laura Lévêque, Irva Hertz-Picciotto, Birgit Puschner, Ellen Fritsche, Jördis Klose, Nynke I. Kramer, Maryse F. Bouchard, P. Charukeshi Chandrasekera, Marc-André Verner
Publikováno v:
Environment International, Vol 183, Iss , Pp 108411- (2024)
Background: Current acceptable chemical exposure levels (e.g., tolerable daily intake) are mainly based on animal experiments, which are costly, time-consuming, considered non-ethical by many, and may poorly predict adverse outcomes in humans. Object
Externí odkaz:
https://doaj.org/article/3c281d7386a04c87b32276cbe2a80b81
Autor:
Carolina Nunes, Susana Proença, Giovanna Ambrosini, David Pamies, Aurélien Thomas, Nynke I. Kramer, Marie-Gabrielle Zurich
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
For ethical, economical, and scientific reasons, animal experimentation, used to evaluate the potential neurotoxicity of chemicals before their release in the market, needs to be replaced by new approach methodologies. To illustrate the use of new ap
Externí odkaz:
https://doaj.org/article/0fbfdfac356046d09b4a042507af3896
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
As toxicologists and risk assessors move away from animal testing and more toward using in vitro models and biological modeling, it is necessary to produce tools to quantify the chemical distribution within the in vitro environment prior to extrapola
Externí odkaz:
https://doaj.org/article/9a47dd5fa13344ad8eb4412c61a45963
Publikováno v:
Hydrology and Earth System Sciences, Vol 25, Pp 1993-2008 (2021)
Declining soil-saturated hydraulic conductivity (Ks) as a result of saline and sodic irrigation water is a major cause of soil degradation. While it is understood that the mechanisms that lead to degradation can cause irreversible changes in Ks, exis
Externí odkaz:
https://doaj.org/article/92ef2f18849140c690cc153fe2e6de28
Autor:
O. J. I. Kramer, P. J. de Moel, S. K. R. Raaghav, E. T. Baars, W. H. van Vugt, W.-P. Breugem, J. T. Padding, J. P. van der Hoek
Publikováno v:
Drinking Water Engineering and Science, Vol 14, Pp 53-71 (2021)
Natural particles are frequently applied in drinking water treatment processes in fixed bed reactors, fluidised bed reactors, and sedimentation processes to clarify water and to concentrate solids. When particles settle, it has been found that, in te
Externí odkaz:
https://doaj.org/article/00a4e194539c4909b3a9620a01976eab
Autor:
Sebastian Jarzina, Stefano Di Fiore, Bernhard Ellinger, Pia Reiser, Sabrina Frank, Markus Glaser, Jiaqing Wu, Femke J. Taverne, Nynke I. Kramer, Angela Mally
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Application of adverse outcome pathways (AOP) and integration of quantitative in vitro to in vivo extrapolation (QIVIVE) may support the paradigm shift in toxicity testing to move from apical endpoints in test animals to more mechanism-based in vitro
Externí odkaz:
https://doaj.org/article/702a50c3a5af4d85a1746fc787ed859f
Autor:
Manon C. Bouwmeester, Yu Tao, Susana Proença, Frank G. van Steenbeek, Roos-Anne Samsom, Sandra M. Nijmeijer, Theo Sinnige, Luc J. W. van der Laan, Juliette Legler, Kerstin Schneeberger, Nynke I. Kramer, Bart Spee
Publikováno v:
Molecules, Vol 28, Iss 2, p 621 (2023)
Emerging advances in the field of in vitro toxicity testing attempt to meet the need for reliable human-based safety assessment in drug development. Intrahepatic cholangiocyte organoids (ICOs) are described as a donor-derived in vitro model for disea
Externí odkaz:
https://doaj.org/article/8b733aeea46746d7985ffe97537d2bfb
Autor:
P Korn, I Kramer, F Schlottig, N Tödtmann, U Eckelt, A Bürki, SJ Ferguson, A Kautz, M Schnabelrauch, U Range, M Kneissel, B Stadlinger
Publikováno v:
European Cells & Materials, Vol 37, Pp 333-346 (2019)
Osseointegration of dental implants can be promoted by implant-surface modifications using bisphosphonate coatings. In addition, it is of clinical interest to promote peri-implant bone formation and to restore bony structure in low bone-mass patients
Externí odkaz:
https://doaj.org/article/e750cbf5bdf84ed280efdadb777966d9