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Akademický článek

Genetic background effects on disease onset and lifespan of the mutant dynactin p150Glued mouse model of motor neuron disease.

Autor: Terry D Heiman-Patterson, Elizabeth P Blankenhorn, Roger B Sher, Juliann Jiang, Priscilla Welsh, Meredith C Dixon, Jeremy I Jeffrey, Philip Wong, Gregory A Cox, Guillermo M Alexander

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0117848 (2015)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease primarily affecting motor neurons in the central nervous system. Although most cases of ALS are sporadic, about 5-10% of cases are familial (FALS) with approximately 20% of FALS cause

Externí odkaz: https://doaj.org/article/f15da2421d78404091f24e11313c9f4d

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Long-Term Effect of Endothelin Receptor Antagonism With Bosentan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure

Autor: Milton Packer, John J.V. McMurray, Henry Krum, Wolfgang Kiowski, Barry M. Massie, Avi Caspi, Craig M. Pratt, Mark C. Petrie, David DeMets, Isaac Kobrin, Sebastien Roux, Karl Swedberg, Craig Pratt, Barry Massie, John McMurray, Eugene Connally, Mark Petrie, Susan Anderson, Jody Barnet, Robert Cody, Henry Dargie, Gary Francis, Barry Greenberg, Juerg Reichen, J. Karrasch, H. Krum, J. Horowitz, J. Amerena, A. Sindone, P. MacDonald, I. Jeffrey, I. Button, E. DeAngelis, R. Pacher, R. Davies, F. McAlister, P. Tanser, B. Sussex, G. Baumann, E. Fleck, H.-G. Olbrich, K. Werdan, H. Klein, F. Staffeld, A.M. Zeiher, C. Roediger, A. Caspi, A. Marmor, L. Reisin, Z. Vered, E. Klainman, N. Roguin, D. Tzivoni, D. David, B. Lewis, E. Abinader, M. Omary, Y. Rosenman, E. Kaluski, R.W. Breedveld, P.H. van der Burgh, P.H.J.M. Dunselman, H.J. Schaafsma, D.P. Hertzberger, N.J. Holwerda, J.A. Kragten, J. van Wijngaarden, J.L. Posma, S.A.M. Said, L.C. Slegers, R.M. Tjon Joe Gin, F.N. Wempe, J.C.L. Wesdorp, A.R. Willems, A.J.A.M. Withagen, J.M. Cornel, L.H.J. van Kempen, W. Kiowski, O. Bertel, T. Moccetti, J.J.V. McMurray, R.A. Greenbaum, P. Bennett, J. Swan, G. Davies, I. Findlay, B. Gould, S. Ball, P. Hubner, A. Lahiri, J. McLay, R. Northcote, S. Saltissi, I. Squire, J. Stephens, M. Stewart, G. Bridgen, J. Walsh, D.J. Webb, Z. Ansari, S. Baron, R. Bellinger, W. Bennet, D. Benvenuti, D. Dawley, L.C. Egbujiobi, I. Eisenstein, T. Little, A. Hertsberg, M. Greenspan, R.J. Grossman, P. Hanley, M. Jesrani, H. Kashou, R. Levites, R. Malik, B. Marmorstein, M. Schwartz, A. Nisar, R. Perelman, M.L. Schwarz, S. Sedlis, J. Srebro, M. Taveras, R. Weiss, P. Weitzman, G.K. Wetherley, M. El Shahawy, D. Kereiakes, L. Campos, G. Peterson, R.S. Small, W.R. Davis, M.-T. Olivari, W. Meengs, M. Koren, P. Slagona, S. Jennison, R. Hershberger, K.F. Browne, D.J. Farnham, S. Zelenkofske, C. Lawless, M. Nathan, T. Meyer, M. Kukin, H. Parekh, R. Berkowitz, J. Boehmer, S. Brozena, P. Dandona, G.W. Dec, V. DeQuattro, P. Fenster, M. Fowler, S. Ellaham, M. Geller, M. Gheorgiade, J. Ghali, S. Murali, S. Katz, C. Bott-Silverman, B. Singh, U. Thadani, G. Torre, J. Teerlink, T. Chandraratna, M. Kesselbrenner, A. Mukherjee, C. Che-Pin Tsai, K. Abbo, M. Goldberg, T. Smith, R.T. Martin

Publikováno v: JACC: Heart Failure. 5:317-326

Objectives The objective of this clinical trial was to evaluate the long-term effect of endothelin receptor antagonism with bosentan on the morbidity and mortality of patients with severe chronic heart failure. Background Endothelin may play a role i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb048a52ef9808b8c1bc2dbcf796ca66
https://doi.org/10.1016/j.jchf.2017.02.021

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