Zobrazeno 1 - 10
of 287
pro vyhledávání: '"I, Janků"'
Publikováno v:
European Journal of Clinical Pharmacology. 44:521-524
Published data on the renal clearance of creatinine, p-aminohippuric acid (PAH) and kanamycin in relation to glomerular filtration rate (GFR) in patients with various renal diseases were analysed by a physiological model of renal clearance. Fitting o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aebacee730dc25c5e568a0d0ebc78d3
https://doi.org/10.1007/bf02440851
https://doi.org/10.1007/bf02440851
Publikováno v:
Cancer Chemotherapy and Pharmacology. 29:450-454
Kinetics of boron disposition after single intravenous injections of two different doses (25 and 50 mg/kg) of mercaptoundecahydrododecaborate sodium (Na2B12H11SH; BSH) was studied in rabbits. Residual boron concentrations in various organs and tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f71075d4085144d3a9f791544bf1fc
https://doi.org/10.1007/bf00684846
https://doi.org/10.1007/bf00684846
Publikováno v:
European Journal of Clinical Pharmacology. 42:337-340
The disposition kinetics and heart rate reducing effect of deacetylmetipranolol (DMP), the active form of the beta-adrenoreceptor blocking agent metipranolol (MP), administered as a single 40 mg oral dose have been compared in 6 patients with cirrhos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d6c55d28361591bfcf6f259fd1a3e9
https://doi.org/10.1007/bf00266359
https://doi.org/10.1007/bf00266359
Autor:
I. Janků
Publikováno v:
European journal of clinical pharmacology. 44(6)
A physiological model of renal drug clearance is presented with the aim of establishing a basis for adjusting drug dosing regimens in renal insufficiency. In agreement with the morphology of blood supply to the nephron, the model assumes serial arran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12de7191b11af4cc5e9cfbfe21bfea2
https://pubmed.ncbi.nlm.nih.gov/8405004
https://pubmed.ncbi.nlm.nih.gov/8405004
Publikováno v:
Vnitrni lekarstvi. 38(6)
The authors provided evidence that the pharmacokinetics of digoxin are influenced by daily rhythms. Using doses of 0.125 mg digoxin by the oral route, after 12 hours they found a statistically higher serum digoxin concentration in the minimum before
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a1eb67b2f0a4d0ca17cbf82eb8c9138
https://pubmed.ncbi.nlm.nih.gov/1529562
https://pubmed.ncbi.nlm.nih.gov/1529562
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 13(4)
The incorporation of equimolar doses of [14C]-palmitic and [3H]-oleic acids into the lipid moiety of hepatocytes after muramyl dipeptide (MDP), adamantylamide dipeptide (AdDP) and levamisole (LM) administration were investigated. The utilization of [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1418fe84a1cde3e8f69b65e0b9286188
https://pubmed.ncbi.nlm.nih.gov/1875776
https://pubmed.ncbi.nlm.nih.gov/1875776
Publikováno v:
Immunopharmacology and immunotoxicology. 13(1-2)
A pharmacokinetic profile of 14C-AdDP with uniformly labelled alanine was investigated. It was shown that the distribution phase after an i.v. administration is very short with a half-life of 2.1 min. The half-life of elimination phase after the i.v.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d059dc45475c249736fe7e708de0e2
https://pubmed.ncbi.nlm.nih.gov/1770213
https://pubmed.ncbi.nlm.nih.gov/1770213
Publikováno v:
Casopis lekaru ceskych. 129(28)
The objective of the present work was to evaluate the practicability of several procedures used for prediction of the serum concentration of lithium in a steady state which will make it possible to adjust the dosage in the early period of treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c18ff6053258ef04e1fd8373ef837db
https://pubmed.ncbi.nlm.nih.gov/2123748
https://pubmed.ncbi.nlm.nih.gov/2123748
Publikováno v:
International journal of clinical pharmacology, therapy, and toxicology. 28(1)
A set of graphical aids to drug dosage adjustment is presented, consisting of 1) a nomogram for evaluation of the dosage adjustment factor, 2) a nomogram for estimation of the creatinine clearance from the serum creatinine level, 3) decision tables f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5b760924618f788b228a61800ccbeb3
https://pubmed.ncbi.nlm.nih.gov/2303310
https://pubmed.ncbi.nlm.nih.gov/2303310
Publikováno v:
Cancer Chemotherapy and Pharmacology. 24:238-242
The continuous-perfusion technique was used in an isolated segment of everted rat jejunum to study transport and biotransformation processes in a series of cancerostatic derivatives of 5-fluorouracil. Metabolic alterations during penetration of the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9425cc233b2f702e03664eccdc57dd
https://doi.org/10.1007/bf00257625
https://doi.org/10.1007/bf00257625