Zobrazeno 1 - 10
of 204
pro vyhledávání: '"I, Holmberg"'
Autor:
Giorgio Turconi, Farhan Alam, Tanima SenGupta, Sini Pirnes-Karhu, Soophie Olfat, Mark S. Schmidt, Kärt Mätlik, Ana Montaño-Rodriguez, Vladimir Heiskanen, Daniel Garton, Petteri T. Piepponen, Charles Brenner, Carina I. Holmberg, Hilde Nilsen, Eija Pirinen, Jaan-Olle Andressoo
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34355- (2024)
Parkinson's disease (PD) is associated with a reduction in 26/20S proteasome and mitochondrial function and depletion of dopamine. Activation of mitochondrial function with the NAD+ precursor nicotinamide riboside (NR) is a potential therapeutic for
Externí odkaz:
https://doaj.org/article/ac4f73d8f115461db81a3d5dd4a624da
Autor:
Johanna Pispa, Elisa Mikkonen, Leena Arpalahti, Congyu Jin, Carmen Martínez-Fernández, Julián Cerón, Carina I. Holmberg
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107886- (2023)
Summary: Polyubiquitinated proteins are primarily degraded by the ubiquitin-proteasome system (UPS). Proteasomes are present both in the cytoplasm and nucleus. Here, we investigated mechanisms coordinating proteasome subcellular localization and acti
Externí odkaz:
https://doaj.org/article/3bb1e6e66f7f4be6b4f447051eae7d00
Autor:
Carmen Martínez-Fernández, Sweta Jha, Elisabet Aliagas, Carina I. Holmberg, Ernest Nadal, Julián Cerón
Publikováno v:
Cells, Vol 12, Iss 6, p 929 (2023)
The deubiquitinase BAP1 (BRCA1-associated protein 1) is associated with BAP1 tumor predisposition syndrome (TPDS). BAP1 is a tumor suppressor gene whose alterations in cancer are commonly caused by gene mutations leading to protein loss of function.
Externí odkaz:
https://doaj.org/article/236ae986484849858475a150a525334b
Autor:
Diogo R. Feleciano, Katrin Juenemann, Manuel Iburg, Inês C. Brás, Carina I. Holmberg, Janine Kirstein
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
A functional protein quality control machinery is crucial to maintain cellular and organismal physiology. Perturbation in the protein homeostasis network can lead to the formation of misfolded and aggregated proteins that are a hallmark of protein co
Externí odkaz:
https://doaj.org/article/edb45883292f4b26948fa4d0fd6d07a9
Autor:
Sweta Jha, Carina I. Holmberg
Publikováno v:
Cells, Vol 9, Iss 8, p 1858 (2020)
The ubiquitin–proteasome system (UPS) and the autophagy–lysosomal pathway (ALP) are the two main eukaryotic intracellular proteolytic systems involved in maintaining proteostasis. Several studies have reported on the interplay between the UPS and
Externí odkaz:
https://doaj.org/article/8f22136cff804ca1b0ce87474cd9b6fe
Autor:
Leena Arpalahti, Alli Laitinen, Jaana Hagström, Harri Mustonen, Arto Kokkola, Camilla Böckelman, Caj Haglund, Carina I Holmberg
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193125 (2018)
Gastric cancer is the second most common cause of cancer-related mortality worldwide. Accurate prediction of disease progression is difficult, and new biomarkers for clinical use are essential. Recently, we reported that the proteasome-associated deu
Externí odkaz:
https://doaj.org/article/ffb5bb144c9142f49f2261bbecaa9a6f
Autor:
Johanna Pispa, Elisa Mikkonen, Leena Arpalahti, Congyu Jin, Carmen Martínez-Fernández, Julián Cerón, Carina I. Holmberg
Regulated protein clearance is vital for cells to maintain protein homeostasis and the conditions essential for survival. The primary machinery for intracellular protein degradation is the ubiquitin– proteasome system (UPS), by which ubiquitin-tagg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39c4f8ecfb5ff1f6704215a54e03ca45
https://doi.org/10.1101/2022.10.03.510264
https://doi.org/10.1101/2022.10.03.510264
Autor:
Leena Arpalahti, Jaana Hagström, Harri Mustonen, Mikael Lundin, Caj Haglund, Carina I Holmberg
Publikováno v:
Tumor Biology, Vol 39 (2017)
Colorectal cancer is among the three most common cancer types for both genders, with a rising global incidence. To date, prognostic evaluation is difficult and largely dependent on early detection and successful surgery. UCHL5/Uch37 is an integral pa
Externí odkaz:
https://doaj.org/article/4ebf198bb1854b11ad66f7473479ea0c
Autor:
Leena Arpalahti, Kapo Saukkonen, Jaana Hagström, Harri Mustonen, Hanna Seppänen, Caj Haglund, Carina I Holmberg
Publikováno v:
Tumor Biology, Vol 39 (2017)
Pancreatic ductal adenocarcinoma is a lethal disease with an overall 5-year survival of less than 5%. Prognosis among surgically treated patients is difficult and identification of new biomarkers is essential for accurate prediction of patient outcom
Externí odkaz:
https://doaj.org/article/483a0a8b75104757bc07dc3ee8922fa5
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183403 (2017)
The ubiquitin-proteasome system (UPS) plays a crucial part in normal cell function by mediating intracellular protein clearance. We have previously shown that UPS-mediated protein degradation varies in a cell type-specific manner in C. elegans. Here,
Externí odkaz:
https://doaj.org/article/c493ff43337940c1809ea9d835deaff6