Zobrazeno 1 - 10
of 309
pro vyhledávání: '"I, Galatulas"'
Publikováno v:
Anticancer research. 18(2A)
In search of more potent compounds endowed with a cytotoxic activity, a new series of basic peptides was synthesized using solid-phase methods. All peptides were purified by preparative reverse-phase HPLC and characterized by electrospray mass spectr
Publikováno v:
Anticancer research. 17(6D)
The most widely-known anti-tumor drugs often induce marked immunosuppression which can give rise to one or more sepses. Anti-infection measures immediately applied can sometimes prove largely ineffective or even useless, the patient dying not as a re
Publikováno v:
Anticancer research. 17(5A)
Synthesis of four multimeric H-Lys-His-His-Arg-Lys-Lys-His-Arg-Lys-Arg-Lys-His-His-Lys-Arg-Lys-oH peptides containing two, four, eight and sixteen branches was carried out by solid phase utilizing a lysine core matrix. These multimeric peptides enhan
Publikováno v:
Anticancer research. 16(6B)
The Knoevenagel reaction between 2-indolinones and 2-chloroindolaldehydes gave 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones which were tested as potential antitumor agents on cultures of HeLa cells. 2-Chloro derivatives with at least one un
Autor:
M, Castelli, G, Baggio, A I, Ruberto, A, Tampieri, P L, Tartoni, T, Rossi, M R, Bossa, I, Galatulas
Publikováno v:
Anticancer research. 16(5A)
Substances like imidazoles, benzimidazoles and also quinolines, whose chemical structure includes a heterocyclic nitrogen, are known to interfere with the microsomal oxidation and, in some cases, with the metabolism of drugs. Since chloroquine and pr
Publikováno v:
Anticancer research. 16(4A)
Synthesis of 2,6-Bis[bis(2-chloroethyl)amino]-4,8-dipiperidino-pyrimido [5,4-d]pyrimidine (DIP-C1) was carried out, and the new derivative showed cytotoxic activity comparable to other alkylating drugs on cultured P388 leukaemia cells and HeLa cells.
Publikováno v:
Anticancer research. 16(2)
We synthesized eight peptides containing from three to twenty residues of arginine, lysine and histidine, using an automated synthetiser and Fmoc strategy. All peptides were purified by preparative reverse-phase HPLC and characterized by electrospay
Publikováno v:
Anticancer research. 16(1)
Several non catecholamine, non glycoside cardiotonic drugs have been described recently. New compounds include amrinone, sulmazole, milrinone and pimobendan. In an attempt to alleviate or prevent anthracycline toxicity, we have reported that these co
Autor:
T, Rossi, I, Galatulas, R, Bossa, A, Tampieri, P, Tartoni, G, Baggio, A I, Ruberto, M, Castelli
Publikováno v:
In vivo (Athens, Greece). 9(3)
It has been demonstrated that 18 alpha-glycyrrhetinic acid, 18 beta-glycyrrhetinic acid and glycyrrhizin effectively inhibit the inception and growth of skin tumours. Moreover, glycyrrhizin and its aglycone act on the growth and differentiation of mo
Publikováno v:
In vivo (Athens, Greece). 9(2)
We have investigated the effects of the H2 receptor antagonist roxatidine on the neuromuscular transmission by using the sciatic nerve-gastrocnemius muscle preparation of the rat in vivo. Roxatidine, administered by i.v. injection, potentiates the ne