Commonly used genomic arrays may lose information due to imperfect coverage of discovered variants for autism spectrum disorder

Autor: Michael Yao, Jason Daniels, Luke Grosvenor, Valerie Morrill, Jason I. Feinberg, Kelly M. Bakulski, Joseph Piven, Heather C. Hazlett, Mark D. Shen, Craig Newschaffer, Kristen Lyall, Rebecca J. Schmidt, Irva Hertz-Picciotto, Lisa A. Croen, M. Daniele Fallin, Christine Ladd-Acosta, Heather Volk, Kelly Benke

Publikováno v: Journal of Neurodevelopmental Disorders, Vol 16, Iss 1, Pp 1-12 (2024)

Abstract Background Common genetic variation has been shown to account for a large proportion of ASD heritability. Polygenic scores generated for autism spectrum disorder (ASD-PGS) using the most recent discovery data, however, explain less variance

Externí odkaz: https://doaj.org/article/065b3e24ae6742c08b0d1d741348b431

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Autor: Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg, Munawar Hussain Soomro, Giancarlo Pesce, Nour Baiz, Elena Isaevska, Michelle Plusquin, Marina Vafeiadi, Theano Roumeliotaki, Sabine A. S. Langie, Arnout Standaert, Catherine Allard, Patrice Perron, Luigi Bouchard, Evelien R. van Meel, Janine F. Felix, Vincent W. V. Jaddoe, Paul D. Yousefi, Cecilia H. Ramlau-Hansen, Caroline L. Relton, Elmar W. Tobi, Anne P. Starling, Ivana V. Yang, Maria Llambrich, Gillian Santorelli, Johanna Lepeule, Lucas A. Salas, Mariona Bustamante, Susan L. Ewart, Hongmei Zhang, Wilfried Karmaus, Stefan Röder, Ana Claudia Zenclussen, Jianping Jin, Wenche Nystad, Christian M. Page, Maria Magnus, Dereje D. Jima, Cathrine Hoyo, Rachel L. Maguire, Tuomas Kvist, Darina Czamara, Katri Räikkönen, Tong Gong, Vilhelmina Ullemar, Sheryl L. Rifas-Shiman, Emily Oken, Catarina Almqvist, Robert Karlsson, Jari Lahti, Susan K. Murphy, Siri E. Håberg, Stephanie London, Gunda Herberth, Hasan Arshad, Jordi Sunyer, Regina Grazuleviciene, Dana Dabelea, Régine P. M. Steegers-Theunissen, Ellen A. Nohr, Thorkild I. A. Sørensen, Liesbeth Duijts, Marie-France Hivert, Vera Nelen, Maja Popovic, Manolis Kogevinas, Tim S. Nawrot, Zdenko Herceg, Isabella Annesi-Maesano, M. Daniele Fallin, Edwina Yeung, Carrie V. Breton, Berthold Koletzko, Nina Holland, Joseph L. Wiemels, Erik Melén, Gemma C. Sharp, Matt J. Silver, Faisal I. Rezwan, John W. Holloway

Publikováno v: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-23 (2023)

Abstract Background Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms under

Externí odkaz: https://doaj.org/article/d655547609c94f51b01a2521002c970a

Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis

Autor: Catherine M. Bulka, Todd M. Everson, Amber A. Burt, Carmen J. Marsit, Margaret R. Karagas, Kristen E. Boyle, Sierra Niemiec, Katerina Kechris, Elizabeth J. Davidson, Ivana V. Yang, Jason I. Feinberg, Heather E. Volk, Christine Ladd-Acosta, Carrie V. Breton, T. Michael O’Shea, Rebecca C. Fry

Publikováno v: Epigenetics, Vol 18, Iss 1 (2023)

The placenta undergoes many changes throughout gestation to support the evolving needs of the foetus. There is also a growing appreciation that male and female foetuses develop differently in utero, with unique epigenetic changes in placental tissue.

Externí odkaz: https://doaj.org/article/ac82bc0e677b4fe1971c034cf1d44fb9

Maternal blood metal concentrations and whole blood DNA methylation during pregnancy in the Early Autism Risk Longitudinal Investigation (EARLI)

Autor: Max T. Aung, Kelly M. Bakulski, Jason I. Feinberg, John F. Dou, John D. Meeker, Bhramar Mukherjee, Rita Loch-Caruso, Christine Ladd-Acosta, Heather E. Volk, Lisa A. Croen, Irva Hertz-Picciotto, Craig J. Newschaffer, M. Daniele Fallin

Publikováno v: Epigenetics, Vol 17, Iss 3, Pp 253-268 (2022)

The maternal epigenome may be responsive to prenatal metals exposures. We tested whether metals are associated with concurrent differential maternal whole blood DNA methylation. In the Early Autism Risk Longitudinal Investigation cohort, we measured

Externí odkaz: https://doaj.org/article/6ab337b726944212b28dba1b8fe8089f

Narcissus in Treatment : The Journey From Fate to Psychological Freedom

Autor: Richard I. Feinberg

This book explores the nature of psychic suffering due to the narcissistic drama and how one can emerge over time to live an autonomous life. The narcissistic drama involves the saga of narcissistic wounding in childhood, resulting from narcissistic