Výsledky vyhledávání - "I, De Lepeleire"

Akademický článek

Sputum RNA signature in allergic asthmatics following allergen bronchoprovocation test

Autor: Rob G.J.A. Zuiker, Catherine Tribouley, Zuzana Diamant, J. Diderik Boot, Adam F. Cohen, K. Van Dyck, I. De Lepeleire, Veronica M. Rivas, Vladislav A. Malkov, Jacobus Burggraaf, Marcella K. Ruddy

Publikováno v: European Clinical Respiratory Journal, Vol 3, Iss 0, Pp 1-17 (2016)

Background: Inhaled allergen challenge is a validated disease model of allergic asthma offering useful pharmacodynamic assessment of pharmacotherapeutic effects in a limited number of subjects. Objectives: To evaluate whether an RNA signature can be

Externí odkaz: https://doaj.org/article/3f8d7fa1f5d8416f955e80a13ac77f16

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Akademický článek

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The nasal mucosal late allergic reaction to grass pollen involves type 2 inflammation (IL-5 and IL-13), the inflammasome (IL-1β), and complement

Autor: R Mogg, G Chen, Trevor T. Hansel, Andrew J. Tan, H Chung, Vladislav A. Malkov, Paul Lavender, I De Lepeleire, Grant C. Nicholson, Nicole Calder, M K Ruddy, Brian Leaker, Catherine Tribouley, L N Carayannopoulos

Publikováno v: Mucosal Immunology. 10:408-420

Non-invasive mucosal sampling (nasosorption and nasal curettage) was used following nasal allergen challenge with grass pollen in subjects with allergic rhinitis, in order to define the molecular basis of the late allergic reaction (LAR). It was foun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77688d222843d9bb8d323b6d75be6df
https://doi.org/10.1038/mi.2016.74

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Sputum RNA signature in allergic asthmatics following allergen bronchoprovocation test

Autor: Veronica M. Rivas, Vladislav A. Malkov, Catherine Tribouley, Rob Zuiker, J. Diderik Boot, Zuzana Diamant, Marcella Ruddy, Adam F. Cohen, K Van Dyck, I De Lepeleire, Jacobus Burggraaf

Publikováno v: European Clinical Respiratory Journal, Vol 3, Iss 0, Pp 1-17 (2016)
European Clinical Respiratory Journal; Vol 3 (2016)
European Clinical Respiratory Journal
European clinical respiratory journal, 3:31324. Taylor & Francis Group

Background : Inhaled allergen challenge is a validated disease model of allergic asthma offering useful pharmacodynamic assessment of pharmacotherapeutic effects in a limited number of subjects. Objectives : To evaluate whether an RNA signature can b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213626b4aa3160c6117f514ff18183a7
http://www.ecrj.net/index.php/ecrj/article/view/31324/47811

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Equivalent Dynamic Human Brain NK1-Receptor Occupancy Following Single-Dose i.v. Fosaprepitant vs. Oral Aprepitant as Assessed by PET Imaging

Publikováno v: Clinical Pharmacology & Therapeutics. 92:243-250

The type 1 neurokinin receptor (NK1R) antagonist aprepitant and its i.v. prodrug fosaprepitant have been approved for prevention of acute and delayed nausea and vomiting associated with chemotherapy. This study evaluated the magnitude and duration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454387a449b7c57da686bdcb529ca993
https://doi.org/10.1038/clpt.2012.62

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Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist

Publikováno v: Journal of Psychopharmacology. 25:329-344

In the accompanying paper we describe how MRK-409 unexpectedly produced sedation in man at relatively low levels of GABAA receptor occupancy (∼10%). Since it was not clear whether this sedation was mediated via the α2/α3 or α1 GABAA subtype(s),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea0a5ae22a6d2851dd26b1e9a8bbbb4
https://doi.org/10.1177/0269881109354928

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MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans

Autor: J. N. de Hoon, Guy Bormans, John R. Atack, M. G Murphy, Sandra M. Sanabria-Bohórquez, I De Lepeleire, A. Van Hecken, Keith A. Wafford, G. R. Dawson, K. Van Laere, Richard Hargreaves, Leslie J. Street, Ruth M. McKernan, Spencer J. Tye, HD Burns

Publikováno v: Journal of Psychopharmacology. 25:314-328

MRK-409 binds to α1-, α2-, α3- and α5-containing human recombinant GABAA receptors with comparable high affinity (0.21–0.40 nM). However, MRK-409 has greater agonist efficacy at the α3 compared with α1 subtypes (respective efficacies relative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e190b386986f0d8f06dedccdb3ce130
https://doi.org/10.1177/0269881109354927

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Akademický článek

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Suppression of Niacin-induced Vasodilation with an Antagonist to Prostaglandin D2 Receptor Subtype 1

Autor: Fang Liu, Eseng Lai, E Vets, Larissa Wenning, Gary P. O'Neill, Nicole Michiels, Tami Crumley, I De Lepeleire, Keith Gottesdiener, John A. Wagner

Publikováno v: Clinical Pharmacology & Therapeutics. 81:849-857

Niacin (nicotinic acid) reduces cardiovascular events in patients with dyslipidemia. However, symptoms associated with niacin-induced vasodilation (e.g., flushing) have limited its use. Laropiprant is a selective antagonist of the prostaglandin D(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90820ffb17b3bf67a5ea4b9b6dad32f3
https://doi.org/10.1038/sj.clpt.6100180

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