Výsledky vyhledávání - "I, Brzozowska"

Nrg1 deficiency modulates the behavioural effects of prenatal stress in mice

Autor: Anastasia S. Suraev, Stephanie M. Todd, Natalia I. Brzozowska, Lala Sarkissian, Dilara Bahceci, Jonathon C. Arnold, David J. Clarke

Publikováno v: Progress in neuro-psychopharmacologybiological psychiatry. 88

Little is known about the exact genes that confer vulnerability or resilience to environmental stressors during early neurodevelopment. Partial genetic deletion of neuregulin 1 (Nrg1) moderates the neurobehavioural effects of stressors applied in ado

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c8064f6f02709c13d584dd5808219a
https://pubmed.ncbi.nlm.nih.gov/29964074

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In vitro model of vasculo-angiogenesis: demonstration that bone marrow derived endothelial progenitor cells form new hybrid capillary blood vessels jointly with gastric endothelial cells

Autor: A, Ahluwalia, M K, Jones, I, Brzozowska, A S, Tarnawski

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 68(6)

Regeneration of blood vessels (neovascularization) is critical for tissue injury healing. The contribution of bone marrow-derived endothelial progenitor cells (BMD-EPCs) to neovascularization during tissue injury healing is not fully elucidated and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70b2f7b8b2892ab22240cdc247035989
https://pubmed.ncbi.nlm.nih.gov/29550796

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The Differential Binding of Antipsychotic Drugs to the ABC Transporter P-Glycoprotein Predicts Cannabinoid–Antipsychotic Drug Interactions

Autor: Erik J de Tonnerre, Jonathon C. Arnold, Kong M. Li, Alexander Wong, Natalia I. Brzozowska, Aurelie A. Boucher, XiaoSuo Wang, Michael Kuligowski, Paul D. Callaghan

Cannabis use increases rates of psychotic relapse and treatment failure in schizophrenia patients. Clinical studies suggest that cannabis use reduces the efficacy of antipsychotic drugs, but there has been no direct demonstration of this in a control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0210e3ae2309b002e015c1f341414153
https://europepmc.org/articles/PMC5603813/

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Genetic deletion of P-glycoprotein alters stress responsivity and increases depression-like behavior, social withdrawal and microglial activation in the hippocampus of female mice

Autor: Kristie Leigh Smith, Cilla Zhou, Michael Kuligowski, Jonathon C. Arnold, Natalia I. Brzozowska, David J. Clarke, Ligia Menezes Cavalcante, Sarah V. Abelev, Stephanie M. Todd, Peter M. Waters

Publikováno v: Brain, behavior, and immunity. 65

P-glycoprotein (P-gp) is an ABC transporter expressed at the blood brain barrier and regulates the brain uptake of various xenobiotics and endogenous mediators including glucocorticoid hormones which are critically important to the stress response. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e832fc46644f46a6594736b2a61860
https://pubmed.ncbi.nlm.nih.gov/28502879

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ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice

Autor: Jessica Booth, Natalia I. Brzozowska, XiaoSuo Wang, Jordyn Stuart, Kong M. Li, Jonathon C. Arnold, Iain S. McGregor

Publikováno v: PeerJ
PeerJ, Vol 4, p e2081 (2016)

Cannabidiol (CBD) is currently being investigated as a novel therapeutic for the treatment of CNS disorders like schizophrenia and epilepsy. ABC transporters such as P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) mediate pharmacore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67ee42041e3b3960162fba859f53f40
https://doi.org/10.7717/peerj.2081

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Conversion L-tryptophan to melatonin in the gastrointestinal tract: the new high performance liquid chromatography method enabling simultaneous determination of six metabolites of L-tryptophan by native fluorescence and UV-VIS detection

Autor: J, Zagajewski, D, Drozdowicz, I, Brzozowska, M, Hubalewska-Mazgaj, T, Stelmaszynska, P M, Laidler, T, Brzozowski

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 63(6)

Melatonin is a major biosynthetic product of pineal gland exerting a potent antioxidant and the reactive oxygen metabolites scavenging activities but the mechanism of formation of this indole at extrapineal sources has not been fully elucidated. It i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7cf87e182485b1670ad18342788ccbd2
https://pubmed.ncbi.nlm.nih.gov/23388477

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Mucosal strengthening activity of central and peripheral melatonin in the mechanism of gastric defense

Autor: I, Brzozowska, A, Ptak-Belowska, M, Pawlik, R, Pajdo, D, Drozdowicz, S J, Konturek, W W, Pawlik, T, Brzozowski

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 60

This review summarizes the involvement of centrally and peripherally applied melatonin, a major hormone of pineal gland, in the mechanism of gastric mucosal integrity, gastroprotection and ulcer healing. Melatonin was originally shown to attenuate ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc483483028b0a0ff3a2425817cdc5b0
https://pubmed.ncbi.nlm.nih.gov/20388945

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Localization and biological activities of melatonin in intact and diseased gastrointestinal tract (GIT)

Autor: S J, Konturek, P C, Konturek, I, Brzozowska, M, Pawlik, Z, Sliwowski, M, Cześnikiewicz-Guzik, S, Kwiecień, T, Brzozowski, G A, Bubenik, W W, Pawlik

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 58(3)

Melatonin (MT), an indole formed enzymatically from L-trytophan (Trp), was first discovered in the bovine pineal gland in 1958 by Lerner et al. Melatonin is the most versatile and ubiquitous hormonal molecule produced not only in the pineal gland but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d99993fa9fd5f642b12748072abcef2c
https://pubmed.ncbi.nlm.nih.gov/17928638

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Role of prostaglandins in gastroprotection and gastric adaptation

Autor: T, Brzozowski, P C, Konturek, S J, Konturek, I, Brzozowska, T, Pawlik

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 56

Since Robert discovery that pretreatment with prostaglandin (PG) applied in non-antisecretory dose can prevent the injury of gastric mucosa induced by necrotizing agents, much attention was paid to the role of these cyclooxygenase (COX) products in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8503f4146013bfc89a9c8ac3d8c2699d
https://pubmed.ncbi.nlm.nih.gov/16247188

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