Zobrazeno 1 - 10
of 247
pro vyhledávání: '"I, Bekersky"'
Publikováno v:
Journal of Lipid Research, Vol 10, Iss 6, Pp 683-686 (1969)
An improved method for the chemical synthesis of HMG-CoA is described. The procedure is designed to prevent the formation of 3-acetoxy-HMG-CoA.
Externí odkaz:
https://doaj.org/article/9f24e623045d448ba6b5393575e41eb3
Publikováno v:
Transplantation Proceedings. 30:1359-1364
Publikováno v:
Therapeutic Drug Monitoring. 18:604-609
A sensitive and selective high-performance liquid chromatographic (HPLC) method has been developed for the determination of amphotericin B in human serum. After methanol deproteinization, amphotericin B and 3-nitrophenol (internal standard) are separ
Publikováno v:
Toxicological Sciences. 23:382-390
The toxicity of inhaled aerosolized pentamidine isethionate solutions in rats and dogs was evaluated. Nose-only exposure equipment and a mass mean aerodynamic particle size of < or = 2 microns were employed. Rats received either a single inhaled dose
Lack of interaction between tacrolimus (FK506) and methotrexate in bone marrow transplant recipients
Autor:
I Bekersky, Richard A. Nash, GW Boswell, Donna Przepiorka, Steve Devine, JL Klein, Rochelle M. Maher, John R. Wingard, Joseph W. Fay, Voravit Ratanatharathorn, William E. Fitzsimmons
Publikováno v:
Bone Marrow Transplantation. 20:49-51
Tacrolimus (FK506) is a macrolide lactone effective in the control of graft-versus-host disease (GVHD). An interaction between high-dose methotrexate and a macrolide antibiotic (pristinamycin) leading to prolonged methotrexate exposure has been descr
Publikováno v:
Journal of clinical pharmacology. 41(9)
Amphotericin B (AmB) in small unilamellar liposomes (AmBisome) provides higher plasma concentrations and greater safety than the conventional deoxycholate formulation. The authors compared the disposition of the liposome's drug and cholesterol compon
Publikováno v:
Pharmaceutical research. 17(12)
Amphotericin B in small, unilamellar liposomes (AmBisome) is safer and produces higher plasma concentrations than other formulations. Because liposomes may increase and prolong tissue exposures, the potential for drug accumulation or delayed toxicity
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(5)
A biodistribution study of 4-[(14)C]cholesterol-AmBisome; a unilamellar liposomal preparation of amphotericin B was conducted to support a radiolabeled human study. The radioactive plasma concentration profile (as measured in microg-Eq/ml of choleste
Autor:
H, Chen, J, Peng, H, Luo, M, Loubeau, X, Wan, D, Xu, S, Qi, M D, Vu, P, Daloze, W E, Fitzsimmons, I, Bekersky, J, Peets, S N, Sehgal, J, Wu
Publikováno v:
Transplantation. 69(8)
In nonprimates, organ allografts are often not rejected after withdrawal of immunosuppression. In this study, we examined whether such a phenomenon also occurs in primates.Vervet monkeys were transplanted with renal allografts and treated for 60 days
Autor:
S, Qi, D, Xu, J, Peng, M D, Vu, J, Wu, I, Bekersky, W E, Fitzsimmons, J, Peets, S, Sehgal, P, Daloze, H, Chen
Publikováno v:
Transplantation. 69(7)
Our previous studies confirmed that tacrolimus (FK506) and sirolimus [rapamycin (RAPA)], in combination, are not antagonistic but are synergistic in the prolongation of heart and small bowel grafts in the rodent. The aim of this study was to confirm