HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression

Autor: Martin C. Abba, María Laura Fabre, Jaeho Lee, Pradeep Tatineni, Hyunsuk Kil, C. Marcelo Aldaz

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

The long-non-coding HOX transcript antisense intergenic RNA (HOTAIR) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). The aim of this study was to characterize the phenotypic effects and signaling pathways modula

Externí odkaz: https://doaj.org/article/5594fe79e39c4b5ba772736ca4a05dd7

Wwox Deletion in Mouse B Cells Leads to Genomic Instability, Neoplastic Transformation, and Monoclonal Gammopathies

Autor: Kevin M. McBride, Hyunsuk Kil, Yunxiang Mu, Joshua B. Plummer, Jaeho Lee, Maciej J. Zelazowski, Manu Sebastian, Martin C. Abba, C. Marcelo Aldaz

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

WWOX (WW domain containing oxidoreductase) expression loss is common in various cancers and characteristic of poor prognosis. Deletions, translocations, and loss of expression affecting the WWOX gene are a common feature of various B cell neoplasms s

Externí odkaz: https://doaj.org/article/e5fe1f8308c34c35a6c5898c7b8a631f

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.

Autor: John H Ludes-Meyers, Hyunsuk Kil, Jan Parker-Thornburg, Donna F Kusewitt, Mark T Bedford, C Marcelo Aldaz

Publikováno v: PLoS ONE, Vol 4, Iss 11, p e7775 (2009)

WWOX, the gene that spans the second most common human chromosomal fragile site, FRA16D, is inactivated in multiple human cancers and behaves as a suppressor of tumor growth. Since we are interested in understanding WWOX function in both normal and c

Externí odkaz: https://doaj.org/article/117f392b76ef4e4a943295d2ece8f259

Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus

Autor: Martín Carlos Abba, Bharathi Hattiangady, Jaeho Lee, Hyunsuk Kil, Jianjun Shen, Ashok K. Shetty, Tabish Hussain, Maheedhar Kodali, Yoko Takata, Bing Shuai, Sahithi Attaluri, C. Marcelo Aldaz

Publikováno v: Neurobiology of Disease, Vol 121, Iss, Pp 163-176 (2019)
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented. These include spinocerebellar ataxia, epilepsy and mental retardation (SCAR12, OMIM: 614322) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40725a1be4d2f3d31a8de281c788382f
https://doi.org/10.1016/j.nbd.2018.09.026

LINC00885 a Novel Oncogenic Long Non-Coding RNA Associated with Early Stage Breast Cancer Progression

Autor: Jaeho Lee, Pradeep Tatineni, Romina Canzoneri, Ezequiel Lacunza, C. Marcelo Aldaz, Hyunsuk Kil, Agustina Gurruchaga, Martín Carlos Abba

Publikováno v: International Journal of Molecular Sciences
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Volume 21
Issue 19
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
International Journal of Molecular Sciences, Vol 21, Iss 7407, p 7407 (2020)

Long intergenic non-protein coding RNA 885 (LINC00885) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). The aim of this study was to characterize the phenotypic e ects and signaling pathways modulated by LINC0088

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7e37df4e1f4febe962f95540085221
http://europepmc.org/articles/PMC7582527