Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Hyunsoo Shawn Je"'
Autor:
Ann-Na Cho, Yoonhee Jin, Yeonjoo An, Jin Kim, Yi Sun Choi, Jung Seung Lee, Junghoon Kim, Won-Young Choi, Dong-Jun Koo, Weonjin Yu, Gyeong-Eon Chang, Dong-Yoon Kim, Sung-Hyun Jo, Jihun Kim, Sung-Yon Kim, Yun-Gon Kim, Ju Young Kim, Nakwon Choi, Eunji Cheong, Young-Joon Kim, Hyunsoo Shawn Je, Hoon-Chul Kang, Seung-Woo Cho
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular m
Externí odkaz:
https://doaj.org/article/4baaa6ea520348a5bdc13ee2f2a1412c
Autor:
Alfred Xuyang Sun, Qiang Yuan, Shawn Tan, Yixin Xiao, Danlei Wang, Audrey Tze Ting Khoo, Levena Sani, Hoang-Dai Tran, Paul Kim, Yong Seng Chiew, Kea Joo Lee, Yi-Chun Yen, Huck Hui Ng, Bing Lim, Hyunsoo Shawn Je
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1942-1953 (2016)
Gamma-aminobutyric acid (GABA)-releasing interneurons play an important modulatory role in the cortex and have been implicated in multiple neurological disorders. Patient-derived interneurons could provide a foundation for studying the pathogenesis o
Externí odkaz:
https://doaj.org/article/091f2fb94fb34db09bbe7c3f12c0d72b
Autor:
Wei Zhang, Paul Jong Kim, Zhongcan Chen, Hidayat Lokman, Lifeng Qiu, Ke Zhang, Steven George Rozen, Eng King Tan, Hyunsoo Shawn Je, Li Zeng
Publikováno v:
eLife, Vol 5 (2016)
During the development, tight regulation of the expansion of neural progenitor cells (NPCs) and their differentiation into neurons is crucial for normal cortical formation and function. In this study, we demonstrate that microRNA (miR)-128 regulates
Externí odkaz:
https://doaj.org/article/aa2bd3fb12e34d8bb2f1789e3fe31d04
Autor:
Kujin Kwon, Hwapyeong Cho, Soyeon Lee, Eun Jeong Cho, Weonjin Yu, Catherine Yen Li Kok, Hyunsoo Shawn Je, Jae‐Ick Kim, Hyung Joon Cho, Taejoon Kwon
Publikováno v:
Aging Cell. 21
Progressive iron accumulation in the substantia nigra in the aged human brain is a major risk factor for Parkinson's disease and other neurodegenerative diseases. Heavy metals, such as iron, produce reactive oxygen species and consequently oxidative
Autor:
Khuong Duy Mac, Muhammad Mohsin Qureshi, Myeongsu Na, Sunghoe Chang, Hyuk-Sang Kwon, Tae Joong Eom, Hyunsoo Shawn Je, Young Ro Kim, Euiheon Chung
In microscopic imaging of biological tissues, particularly real-time visualization of neuronal activities, rapid acquisition of volumetric images poses a prominent challenge. Typically, two-dimensional (2D) microscopy can be devised into an imaging s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e0ef3b452088231852ab0248c3bc6b4
https://doi.org/10.1101/2021.12.01.470673
https://doi.org/10.1101/2021.12.01.470673
Autor:
Tae Hwan Kwak, Chanhyeok Park, Kee-Pyo Kim, Im Joo Rhyu, Woong Sun, Kwon Ho Hong, Dong Wook Han, Hyunsoo Shawn Je, Huck-Hui Ng, Ji Eun Na, ChiHye Chung, Sai Hali, Ji Hyun Kang, Ju Hyun Lee, Junghyun Jo, Nam Kim, Jonghun Kim, Ha Kyun Ryu, Jeongwoo Kwon
Publikováno v:
STEM CELLS. 38(6):727-740
Recent studies have demonstrated the generation of midbrain-like organoids (MOs) from human pluripotent stem cells. However, the low efficiency of MO generation and the relatively immature and heterogeneous structures of the MOs hinder the translatio
Autor:
Mui Hoon Nai, Hoang-Dai Tran, Huck-Hui Ng, Chwee Teck Lim, Kah-Leong Lim, Haidun Yan, Koji Itahana, Menglan Zhang, Stephanie Wai Lin Lim, Qiang Yuan, Yoko Itahana, Giuseppe D'Agostino, Yong-hui Jiang, Alfred Xuyang Sun, Eng-King Tan, Danlei Wang, Hidayat Lokman, Owen J. L. Rackham, Weonjin Yu, Stuart A. Cook, Grace Lim, Ya Yin Chang, Masahiro Fukuda, Hyunsoo Shawn Je, Jiong Tang
Publikováno v:
Science. 366:1486-1492
Hyperexcitable neurons in brain organoids Individuals with Angelman syndrome experience intellectual disability and seizures throughout their lives. In this condition, ubiquitin-mediated degradation of a key potassium channel is disrupted, allowing f
Autor:
Jung Seung Lee, Yun-Gon Kim, Hoon Chul Kang, Ji Hun Kim, Ann Na Cho, Dong-Jun Koo, Jin Kim, Yi Sun Choi, Ju-Young Kim, Yoonhee Jin, Weonjin Yu, Sung-Hyun Jo, Gyeong-Eon Chang, Nakwon Choi, Won-Young Choi, Sung-Yon Kim, Seung Woo Cho, Dongyoon Kim, Eunji Cheong, Jung-Hoon Kim, Yeonjoo An, Hyunsoo Shawn Je, Young Joon Kim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
Nature Communications
Nature Communications
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro model to recapitulate human brain development and neurological diseases. However, the current systems for brain organoid culture require further improvement
Autor:
Hidayat Lokman, Huck-Hui Ng, Audrey Tze Ting Khoo, Wei-Yi Ong, Junghyun Jo, Grace Lim, Hoang Dai Tran, Seung-Jae Lee, Weonjin Yu, Lin Yang, Lai Ping Yaw, Ya Yin Chang, Jessica Jiaxin Xie, Kah-Leong Lim, Bin Xiao, Eng-King Tan, Tzuen Yih Saw, Byung Chul Jung, Alfred Xuyang Sun, Hyunsoo Shawn Je
Publikováno v:
Annals of neurology. 90(3)
Objective: We utilized human midbrain-like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α-synuclein (α-syn; SNCA) perturbations to investigate genotype-to-phenotype relationships in Parki
Publikováno v:
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.
Neuropsychiatric manifestations of coronavirus disease 2019 (COVID-19) have been increasingly recognized. However, the pathophysiology of COVID-19 in the central nervous system remains unclear. Brain organoid models derived from human pluripotent ste