Absolute oral bioavailability of milvexian spray‐dried dispersion formulation under fasted and fed conditions in healthy adult participants: An intravenous microtracer approach

Autor: Praneeth Jarugula, Sharif Soleman, Hyunmoon Back, Lisa J. Christopher, Dara Hawthorne, Ronald Aronson, Anh Bui, Angela Mirzac, Antoinette Ajavon‐Hartmann, Vidya Perera, Bindu Murthy, Samira Merali

Publikováno v: Clinical and Translational Science, Vol 17, Iss 10, Pp n/a-n/a (2024)

Abstract Milvexian is an oral, small‐molecule factor XIa inhibitor being developed to prevent thromboembolic events. This study assessed the absolute bioavailability (F) of milvexian following single doses of milvexian spray‐dried dispersion (SDD

Externí odkaz: https://doaj.org/article/a7d11c4e9bf24a458a922f4fbe98bcfc

A Reactive Oxygen Species-Scavenging ‘Stealth’ Polymer, Poly(thioglycidyl glycerol), Outperforms Poly(ethylene glycol) in Protein Conjugates and Nanocarriers and Enhances Protein Stability to Environmental and Biological Stressors

Autor: Richard d’Arcy, Farah El Mohtadi, Nora Francini, Carlisle R. DeJulius, Hyunmoon Back, Arianna Gennari, Mike Geven, Maria Lopez-Cavestany, Zulfiye Yesim Turhan, Fang Yu, Jong Bong Lee, Michael R. King, Leonid Kagan, Craig L. Duvall, Nicola Tirelli

Publikováno v: D'Arcy, R, El Mohtadi, F, Francini, N, Dejulius, C R, Back, H, Gennari, A, Geven, M, Lopez-Cavestany, M, Turhan, Z Y, Yu, F, Lee, J B, King, M R, Kagan, L, Duvall, C L & Tirelli, N 2022, ' A Reactive Oxygen Species-Scavenging Stealth' Polymer, Poly(thioglycidyl glycerol), Outperforms Poly(ethylene glycol) in Protein Conjugates and Nanocarriers and Enhances Protein Stability to Environmental and Biological Stressors ', Journal of the American Chemical Society, vol. 144, no. 46, pp. 21304-21317 . https://doi.org/10.1021/jacs.2c09232

This study addresses well-known shortcomings of poly(ethylene glycol) (PEG)-based conjugates. PEGylation is by far the most common method employed to overcome immunogenicity and suboptimal pharmacokinetics of, for example, therapeutic proteins but ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d084ca9f80077be1bc82ced68025a47
https://doi.org/10.1021/jacs.2c09232