Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hyungwoo Moon"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 372-376 (2020)
3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives were designed and synthesised as selective inhibitors of JNK3, a target for the treatment of neurodegenerative diseases. Following previous studies, we have designed JNK3 inhibitors to reduce the mol
Externí odkaz:
https://doaj.org/article/8cf4d412b5ed44ec9b5cedf3e9def8dd
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1110-1115 (2020)
A series of 4-arylamido 5-methylisoxazole derivatives with quinazoline core was designed and synthesised based on conformational rigidification of a previous type II FMS inhibitor. Most of quinazoline analogues displayed activity against FLT3 and FLT
Externí odkaz:
https://doaj.org/article/10d5666f0713479894e922f610a5859c
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1314-1320 (2019)
BRAF belongs to the upstream portion of the MAPK pathway, which is involved in cell proliferation and survival. When mutations occur in BRAF, downstream MEK and ERK are phosphorylated irrespective of RAS, resulting in melanoma-like cancer. Over the y
Externí odkaz:
https://doaj.org/article/07c5c571304347478ec389292c8ebde7
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1716-1721 (2019)
A series of 4-arylamido 5-methylisoxazole derivatives incorporating benzimidazole was designed and synthesised by conformational restriction of an in-house type II FMS inhibitor. Kinase profiling of one compound revealed interesting features, with in
Externí odkaz:
https://doaj.org/article/6209deee62bc403299eb06ef984dbde7
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11084 (2021)
As members of the MAPK family, c-Jun-N-terminal kinases (JNKs) regulate the biological processes of apoptosis. In particular, the isoform JNK3 is expressed explicitly in the brain at high levels and is involved in the pathogenesis of neurodegenerativ
Externí odkaz:
https://doaj.org/article/8a70d9e28a464869a9270dfa8575aed4
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5, p 1698 (2020)
We designed and synthesized 1-pyrimidinyl-2-aryl-4, 6-dihydropyrrolo [3,4-d] imidazole-5(1H)-carboxamide derivatives as selective inhibitors of c-Jun-N-terminal Kinase 3 (JNK3), a target for the treatment of neurodegenerative diseases. Based on the c
Externí odkaz:
https://doaj.org/article/d9148fd904a1485d906280224d467280
Autor:
Joonhong Jun, Hyungwoo Moon, Songyi Yang, Junghun Lee, Jihyun Baek, Hyejin Kim, Hyunwook Cho, Kyungrim Hwang, Soyeon Ahn, Yuro Kim, Gibeom Kim, HyunTae Kim, Hoseok Kwon, Jung-Mi Hah
Publikováno v:
Journal of Medicinal Chemistry. 66:6372-6390
Publikováno v:
European journal of medicinal chemistry. 245(Pt 1)
JNK3 is a key factor driving the pathophysiology of neuronal apoptosis. Since demonstrating the therapeutic potential of JNK3 inhibitors in Alzheimer's disease, we aimed to broaden their chemical diversity for drug development. In continuation with o
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1110-1115 (2020)
A series of 4-arylamido 5-methylisoxazole derivatives with quinazoline core was designed and synthesised based on conformational rigidification of a previous type II FMS inhibitor. Most of quinazoline analogues displayed activity against FLT3 and FLT
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 372-376 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry
3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives were designed and synthesised as selective inhibitors of JNK3, a target for the treatment of neurodegenerative diseases. Following previous studies, we have designed JNK3 inhibitors to reduce the mol