Zobrazeno 1 - 10
of 301
pro vyhledávání: '"Hyunggee KIM"'
Autor:
Sang-Hun Choi, Junseok Jang, Yoonji Kim, Cheol Gyu Park, Seon Yong Lee, Hyojin Kim, Hyunggee Kim
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-10 (2024)
Abstract Although bevacizumab (BVZ), a representative drug for anti-angiogenesis therapy (AAT), is used as a first-line treatment for patients with glioblastoma (GBM), its efficacy is notably limited. Whereas several mechanisms have been proposed to
Externí odkaz:
https://doaj.org/article/61a1649a91e0426a8f13ce9fdc242666
Autor:
Seon Yong Lee, Sang-Hun Choi, Yoonji Kim, Hee-Sung Ahn, Young-Gyu Ko, Kyunggon Kim, Sung Wook Chi, Hyunggee Kim
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Glioblastoma (GBM) is more difficult to treat than other intractable adult tumors. The main reason that GBM is so difficult to treat is that it is highly infiltrative. Migrasomes are newly discovered membrane structures observed i
Externí odkaz:
https://doaj.org/article/33d4aedb482746fcb9bff621b6b7cb6d
Autor:
Hyun Bo Shim, Hyunjeong Lee, Hwa Yeon Cho, Young Ho Jo, Lionel Tarrago, Hyunggee Kim, Vadim N. Gladyshev, Byung Cheon Lee
Publikováno v:
Antioxidants, Vol 13, Iss 11, p 1348 (2024)
MsrB1 is a thiol-dependent enzyme that reduces protein methionine-R-sulfoxide and regulates inflammatory response in macrophages. Therefore, MsrB1 could be a promising therapeutic target for the control of inflammation. To identify MsrB1 inhibitors,
Externí odkaz:
https://doaj.org/article/ae9880fb86dd4a8781100f2788622b20
Autor:
Jung Yun Kim, Nayoung Hong, Sehyeon Park, Seok Won Ham, Eun-Jung Kim, Sung-Ok Kim, Junseok Jang, Yoonji Kim, Jun-Kyum Kim, Sung-Chan Kim, Jong-Whi Park, Hyunggee Kim
Publikováno v:
Cell Death and Disease, Vol 14, Iss 12, Pp 1-13 (2023)
Abstract Jagged1 (JAG1) is a Notch ligand that correlates with tumor progression. Not limited to its function as a ligand, JAG1 can be cleaved, and its intracellular domain translocates to the nucleus, where it functions as a transcriptional cofactor
Externí odkaz:
https://doaj.org/article/94a6b7e05e354f21b848aee333449959
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0307943 (2024)
Notch ligands [jagged (JAG) and, delta-like (DLL) families] and receptors [NOTCH family] are key regulators of Notch signaling. NOTCH signaling contributes to vascular development, tissue homeostasis, angiogenesis, and cancer progression. To elucidat
Externí odkaz:
https://doaj.org/article/cabbbffdb7f84d02bb321408b4587a5e
Autor:
Jong-Whi Park, Omer Kilic, Minh Deo, Kevin Jimenez-Cowell, Engin Demirdizen, Hyunggee Kim, Şevin Turcan
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Capicua (CIC) is an important downstream molecule of RTK/RAS/MAPK pathway. The regulatory mechanism of CIC underlying tumorigenesis in oligodendroglioma, where CIC is frequently mutated, has yet to be fully elucidated. Using patient-derived
Externí odkaz:
https://doaj.org/article/fa0f02994ce642d6bf67a50fef6ccde1
Autor:
Se-Mi Kim, Eun-Ha Kim, Mark Anthony B. Casel, Young-Il Kim, Rong Sun, Mi-Jeong Kwak, Ji-Seung Yoo, Mina Yu, Kwang-Min Yu, Seung-Gyu Jang, Rare Rollon, Jeong Ho Choi, Juryeon Gil, Kiyoung Eun, Hyunggee Kim, Armin Ensser, Jungwon Hwang, Min-Suk Song, Myung Hee Kim, Jae U. Jung, Young Ki Choi
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113077- (2023)
Summary: With the emergence of multiple predominant SARS-CoV-2 variants, it becomes important to have a comprehensive assessment of their viral fitness and transmissibility. Here, we demonstrate that natural temperature differences between the upper
Externí odkaz:
https://doaj.org/article/5e952bf83ad14ff8886740478ba9fdf0
Autor:
Israt Jahan Tulip, Sung-Ok Kim, Eun-Jung Kim, Jaebong Kim, Jae Yong Lee, Hyunggee Kim, Sung-Chan Kim
Publikováno v:
Animal Cells and Systems, Vol 0, Iss 0, Pp 1-10 (2021)
Glioblastoma multiforme (GBM) is the most aggressive primary brain cancer and this is due to cancer cells being apoptosis-resistant and having increased cell proliferation, migration, invasion, and angiogenesis properties. Previous studies have indic
Externí odkaz:
https://doaj.org/article/ec4ab3664458479d8fd8ebeef09bdda1
Autor:
Jinlong Yin, Sung Soo Kim, Eunji Choi, Young Taek Oh, Weiwei Lin, Tae-Hoon Kim, Jason K. Sa, Jun Hee Hong, Se Hwan Park, Hyung Joon Kwon, Xiong Jin, Yeonhee You, Ji Hye Kim, Hyunggee Kim, Jaekyoung Son, Jeongwu Lee, Do-Hyun Nam, Kui Son Choi, Bingyang Shi, Ho-Shin Gwak, Heon Yoo, Antonio Iavarone, Jong Heon Kim, Jong Bae Park
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
How glioblastoma stem cells (GSCs) and tumor-associated macrophages (TAMs) interact to promote progression of glioblastoma multiforme (GBM) is currently unclear. Here, the authors demonstrate a role for the ARS2/MAGL signalling in regulating self-ren
Externí odkaz:
https://doaj.org/article/2f6a1b63b819473598e5e4487f1b7d64
Autor:
Sunyoung Seo, Nayoung Hong, Junhyuk Song, Dohyeon Kim, Yoonjung Choi, Daeyoup Lee, Sangyong Jon, Hyunggee Kim
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2684 (2022)
Cancer stem-like cells (CSCs) are considered promising targets for anti-cancer therapy owing to their role in tumor progression. Extensive research is, therefore, being carried out on CSCs to identify potential targets for anti-cancer therapy. Howeve
Externí odkaz:
https://doaj.org/article/5045c45d19d2418c9cb4d98afb8cfc9a