Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Hyung-Seop Youn"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
DNA polymerase plays a critical role in passing the genetic information of any living organism to its offspring. DNA polymerase from enterobacteria phage RB69 (RB69pol) has both polymerization and exonuclease activities and has been extensively studi
Externí odkaz:
https://doaj.org/article/b9d628bd2fc8453ca0fe5f580adb5119
Autor:
Hyung-Seop Youn, Mun-Kyoung Kim, Gil Bu Kang, Tae Gyun Kim, Jung-Gyu Lee, Jun Yop An, Kyoung Ryoung Park, Youngjin Lee, Jung Youn Kang, Hye-Eun Song, Inju Park, Chunghee Cho, Shin-Ichi Fukuoka, Soo Hyun Eom
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62027 (2013)
We have determined the crystal structure of porcine quinolinate phosphoribosyltransferase (QAPRTase) in complex with nicotinate mononucleotide (NAMN), which is the first crystal structure of a mammalian QAPRTase with its reaction product. The structu
Externí odkaz:
https://doaj.org/article/49921e68bd3c4cfe954f857afe59ac6f
Autor:
Jung-Gyu Lee, Ki Hun Park, Young Bae Ryu, Kyoung Ryoung Park, Hyung-Seop Youn, Youngjin Lee, Jun Yop An, Soo Hyun Eom, Mi Sun Jin, Jung Youn Kang
Publikováno v:
Biochemical and Biophysical Research Communications
Anti-bacterial and anti-viral neuraminidase agents inhibit neuraminidase activity catalyzing the hydrolysis of terminal N-acetylneuraminic acid (Neu5Ac) from glycoconjugates and help to prevent the host pathogenesis that lead to fatal infectious dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb96198440d498d79ea99b182bb9264
http://europepmc.org/articles/PMC7092837
http://europepmc.org/articles/PMC7092837
Autor:
Kyoung Ryoung Park, Jia Jia Lim, Tue Tu Ly, Jung Youn Kang, So Young Yoon, Jin Kuk Yang, Youngsoo Jun, Hyung-Seop Youn, Youngjin Lee, Jung-Gyu Lee, Soo Hyun Eom, Tae Gyun Kim, Jun Yop An
Publikováno v:
FEBS Letters. 590:4402-4413
The interaction of the rhomboid pseudoprotease Derlin-1 and p97 is crucial for the retrotranslocation of polyubiquitinated substrates in the endoplasmic reticulum-associated degradation (ERAD) pathway. We report a 2.25 A resolution structure of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d8ff2b85a9918b9ed4fa32fd5ccdcf
https://doi.org/10.1002/1873-3468.12447
https://doi.org/10.1002/1873-3468.12447
Autor:
Akinori Kidera, Sam-Yong Park, Jung Youn Kang, Yung Joon Yoo, Jung-Gyu Lee, Hyung-Seop Youn, Soo Hyun Eom
Publikováno v:
Biochemical and biophysical research communications. 506(1)
Ubiquitin-conjugating enzymes (E2) form thioester bonds with ubiquitin (Ub), which are subsequently transferred to target proteins for cellular progress. Ube2K/E2-25K (a class II E2 enzyme) contains a C-terminal ubiquitin-associated (UBA) domain that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90ebc69322bdfacdb04ce4058038f4c1
https://pubmed.ncbi.nlm.nih.gov/30336976
https://pubmed.ncbi.nlm.nih.gov/30336976
Autor:
Kahee Shin, Hong Ki Song, Kyoung Ryoung Park, Choon Kee Min, Yeon-Soo Kim, Jimin Wang, Zee Yong Park, Ji Hun Kim, Moonkyung Kang, Hyung-Seop Youn, Youngjin Lee, Do Han Kim, Dongwook Kim, Jia Jia Lim, Soo Hyun Eom, Tae Gyun Kim, Yunki Lim, Jun Yop An, Jihye Kim, Jung Youn Kang, Jung-Gyu Lee
Publikováno v:
EMBO Reports
The mitochondrial calcium uniporter (MCU) is responsible for mitochondrial calcium uptake and homeostasis. It is also a target for the regulation of cellular anti‐/pro‐apoptosis and necrosis by several oncogenes and tumour suppressors. Herein, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc703a8e93bacf007c221e38b4724d3e
https://doi.org/10.15252/embr.201540436
https://doi.org/10.15252/embr.201540436
Autor:
Ji-Young Park, Ki Hun Park, Woo Song Lee, Jung Keun Cho, Hyung-Seop Youn, Youngjin Lee, Young Bae Ryu, Soo Hyun Eom, Young-Min Kim
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
Acta Crystallographica Section D Biological Crystallography
Acta Crystallographica Section D Biological Crystallography
The crystal structure of sialidase from C. perfringens, a pathogenic bacterium causing various gastrointestinal diseases, was determined in complex with a potent natural polyphenolic geranylated flavonoid-based inhibitor. The complex structure and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45ac0b12e5a61934bc8595692de15a4
http://europepmc.org/articles/PMC4014123
http://europepmc.org/articles/PMC4014123
Autor:
Min-Ju Kim, Youhoon Cheong, Sangmee Ahn Jo, Hyunyoung Kim, Suk Kyung Lee, Hyung-Seop Youn, Sang Ick Park
Publikováno v:
Biochemical and Biophysical Research Communications. 438:765-771
We recently reported that glutamate carboxypeptidase II (GCPII) has a new physiological function degrading amyloid-β (Aβ), distinct from its own hydrolysis activity in N-acetyl-L-aspartyl-L-glutamate (NAAG); however, its underlying mechanism remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3775d33881cc06bf2ce791d8db64cff8
https://doi.org/10.1016/j.bbrc.2013.07.059
https://doi.org/10.1016/j.bbrc.2013.07.059
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 69:147-152
Upc2, a zinc-cluster transcription factor, is a regulator of ergosterol biosynthesis in yeast. In response to sterol levels, the transcriptional activity of Upc2 is controlled by the C-terminal domain. In this study, the C-terminal regulatory domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1782621ed3ca5b4a3e7fa08f543f568f
https://doi.org/10.1107/s1744309112051597
https://doi.org/10.1107/s1744309112051597
Autor:
Tae Gyun Kim, Min-Sung Kwon, Jung-Gyu Lee, Chang-Duk Jun, Jung Youn Kang, Sung Haeng Lee, Soo Hyun Eom, Hae-Kap Cheong, Hyung-Seop Youn, Youngjin Lee, Jun Yop An, Jia Jia Lim, Kyoung Ryoung Park, Jeong Soon Park, Woo Keun Song
Publikováno v:
SCIENTIFIC REPORTS(6)
EFhd2/Swiprosin-1 is a cytoskeletal Ca2+-binding protein implicated in Ca2+-dependent cell spreading and migration in epithelial cells. EFhd2 domain architecture includes an N-terminal disordered region, a PxxP motif, two EF-hands, a ligand mimic hel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67192d6e68e462e3dbfda60867bc35cd