Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Hyung‐Joon Kwon"'
Autor:
Woo Seon Choi, Hyung‐Joon Kwon, Eunbi Yi, Haeun Lee, Jung Min Kim, Hyo Jin Park, Eun Ji Choi, Myoung Eun Choi, Young Hoon Sung, Chong Hyun Won, Chang Ohk Sung, Hun Sik Kim
Publikováno v:
Advanced Science, Vol 11, Iss 29, Pp n/a-n/a (2024)
Abstract Distant metastasis, the leading cause of cancer death, is efficiently kept in check by immune surveillance. Studies have uncovered peripheral natural killer (NK) cells as key antimetastatic effectors and their dysregulation during metastasis
Externí odkaz:
https://doaj.org/article/96488816109f40e28e23097a63b02c67
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-13 (2023)
Abstract Necroptosis is a form of regulated necrosis and is executed by MLKL when MLKL is engaged in triggering the rupture of cell plasma membrane. MLKL activation also leads to the protease, ADAMs-mediated ectodomain shedding of cell surface protei
Externí odkaz:
https://doaj.org/article/d40fd69c4fe34ef48b3eb9894abd9797
Autor:
Peter Radvak, Hyung-Joon Kwon, Martina Kosikova, Uriel Ortega-Rodriguez, Ruoxuan Xiang, Je-Nie Phue, Rong-Fong Shen, James Rozzelle, Neeraj Kapoor, Taylor Rabara, Jeff Fairman, Hang Xie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mutant SARS-CoV-2 strains such as B.1.1.7 and B.1.351 have been termed variants of concerns (VoC) due to their enhanced virulence. Here the authors show, using K18-hACE2 transgenic mouse models, that these two VoCs are also more pathogenic in mice, a
Externí odkaz:
https://doaj.org/article/b798cec113434016bcaf2b4323e29ab0
Autor:
Hyung-Joon Kwon, Martina Kosikova, Weichun Tang, Uriel Ortega-Rodriguez, Peter Radvak, Ruoxuan Xiang, Kelly E. Mercer, Levan Muskhelishvili, Kelly Davis, Jerrold M. Ward, Ivan Kosik, Jaroslav Holly, Insung Kang, Jonathan W. Yewdell, Ewan P. Plant, Wilbur H. Chen, Mallory C. Shriver, Robin S. Barnes, Marcela F. Pasetti, Bin Zhou, David E. Wentworth, Hang Xie
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105507- (2022)
Summary: Here we interrogate the factors responsible for SARS-CoV-2 breakthrough infections in a K18-hACE2 transgenic mouse model. We show that Delta and the closely related Kappa variant cause viral pneumonia and severe lung lesions in K18-hACE2 mic
Externí odkaz:
https://doaj.org/article/f958b51bb99d4ff58bffab752bca1d75
Autor:
Jin Young Baik, Zhaoshan Liu, Delong Jiao, Hyung-Joon Kwon, Jiong Yan, Chamila Kadigamuwa, Moran Choe, Ross Lake, Michael Kruhlak, Mayank Tandon, Zhenyu Cai, Swati Choksi, Zheng-gang Liu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Tumour necroptosis is regulated by RIPK3 during tumour development. Here the authors show that ZBP1 is an upstream mediator of RIPK3 in tumour necroptosis and that glucose deprivation induces the release of mitochondrial DNA, which binds to ZBP1 to a
Externí odkaz:
https://doaj.org/article/c059cce4955c4850a438f4f3231f7e07
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Natural killer (NK) cells are innate cytotoxic lymphocytes that efficiently eliminate malignant and virus-infected cells without prior activation via the directed and focused release of lytic granule contents for target cell lysis. This cytolytic pro
Externí odkaz:
https://doaj.org/article/eb32828fea69404a98a837c3eb59fdbf
Autor:
Hyung-Joon Kwon, Heejae Lee, Go-Eun Choi, Soon Jae Kwon, Ah Young Song, So Jeong Kim, Woo Seon Choi, Sang-Hyun Hwang, Sun Chang Kim, Hun Sik Kim
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Ginsenosides are the principal active components of ginseng and are considered attractive candidates for combination cancer therapy because they can kill tumors and have favorable safety profiles. However, the overall benefit of ginsenosides remains
Externí odkaz:
https://doaj.org/article/799510c7cbe645eb8c78140b07eee863
Autor:
Hyung-Joon Kwon, Go-Eun Choi, Sangryeol Ryu, Soon Jae Kwon, Sun Chang Kim, Claire Booth, Kim E. Nichols, Hun Sik Kim
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
NK cell activation requires multiple signals. Here the authors show that while NKG2D, 2B4, or DNAM-1 receptor activation is insufficient to induce cytokine production, these signals synergize by Vav-1-mediated NF-κB multiphosphorylation, and this si
Externí odkaz:
https://doaj.org/article/1e231bdd2f5b49878bcef0ac1df70c15
Autor:
Ji Heui Kim, Gye Eun Kim, Gye Song Cho, Hyung-Joon Kwon, Chul Hyun Joo, Hun Sik Kim, Yong Ju Jang
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77177 (2013)
Natural killer (NK) cells are multicompetent lymphocytes of the innate immune system that play a central role in host defense and immune regulation. Although increasing evidence suggests that innate immunity plays a key role in the pathogenesis of ch
Externí odkaz:
https://doaj.org/article/7688c422fe85450f9c15550b5cc8c7c5
Autor:
Sang-Uk Seo, Hyung-Joon Kwon, Hyun-Jeong Ko, Young-Ho Byun, Baik Lin Seong, Satoshi Uematsu, Shizuo Akira, Mi-Na Kweon
Publikováno v:
PLoS Pathogens, Vol 7, Iss 2, p e1001304 (2011)
Type I interferon (IFN-I) plays a critical role in the homeostasis of hematopoietic stem cells and influences neutrophil influx to the site of inflammation. IFN-I receptor knockout (Ifnar1⁻/⁻) mice develop significant defects in the infiltration
Externí odkaz:
https://doaj.org/article/1be4530995784fb6beb466ce71f8c488