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Akademický článek

Rational design and synthesis of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants

Autor: Daseul Im, Joonhong Jun, Jihyun Baek, Haejin Kim, Dahyun Kang, Hyunah Bae, Hyunwook Cho, Jung-Mi Hah

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 472-486 (2022)

Fms-like tyrosine kinase 3 (FLT3) has been verified as a therapeutic target for acute myeloid leukaemia (AML). In this study, we report a series of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazol-5-yl benzamide and phenyl urea derivatives as potent FLT3 inhi

Externí odkaz: https://doaj.org/article/3b5f7ce66d344764bc9eb1d10213a431

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Akademický článek

Design and Synthesis of Aminopyrimidinyl Pyrazole Analogs as PLK1 Inhibitors Using Hybrid 3D-QSAR and Molecular Docking

Autor: Swapnil P. Bhujbal, Hyejin Kim, Hyunah Bae, Jung-Mi Hah

Publikováno v: Pharmaceuticals, Vol 15, Iss 10, p 1170 (2022)

Cancer continues to be one of the world’s most severe public health issues. Polo-like kinase 1 (PLK1) is one of the most studied members of the polo-like kinase subfamily of serine/threonine protein kinases. PLK1 is a key mitotic regulator responsi

Externí odkaz: https://doaj.org/article/57f14877c7804146b8b398d1be18d9d7

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