Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hyun-Myoung Cha"'
Publikováno v:
Biotechnology and Bioprocess Engineering. 26:993-1001
Publikováno v:
Biotechnology and Bioprocess Engineering. 26:286-293
Sialylation, which is considered as a critical quality attribute, plays important roles in pharmacokinetics of recombinant proteins. Terminal sialic acids of glycoproteins are modulated by intracellular sialyltransferase (ST) and extracellular sialid
Publikováno v:
KSBB Journal. 36:49-59
Publikováno v:
KSBB Journal. 34:73-79
Autor:
Jin-Hyuk Lim, Jihye Kim, Hyun-Myoung Cha, Seung-Hoon Kang, Hye-Jin Han, Minkyoo Ji, Su-Hwan Cheon, Minju Kang, Ha Hyung Kim, Dong-Il Kim
Publikováno v:
Enzyme and Microbial Technology. 157:110007
Cytotoxic T-lymphocyte-associated protein 4-Ig (CTLA4-Ig) produced using Chinese hamster ovary (CHO) cell lines is a fusion protein of CTLA4 and the Fc region of antibody. In the present study, we identified and overexpressed genes capable of increas
Publikováno v:
Process Biochemistry. 66:197-204
Chinese hamster ovary (CHO) cells have been widely used for the production of glycoproteins due to various advantages such as high productivity, ease of genetic manipulation, adaptability to serum-free media, and human-like glycosylation. Glycosylati
Publikováno v:
KSBB Journal. 32:193-198
Publikováno v:
Enzyme and Microbial Technology. 103:53-58
Terminal sialic acids on N-glycan of recombinant human erythropoietin are very important for in vivo half-life, as this glycoprotein has three N-glycosylation sites. N-acetylglucosaminyltransferases I, II, IV, and V (i.e. Mgat1, Mgat2, Mgat4, and Mga
Publikováno v:
KSBB Journal. 32:90-95
Publikováno v:
KSBB Journal. 31:270-276
In glycoprotein, Terminal sialic acid residues of Nlinked glycan are imperative things because they prevent the recognition from asialoglycoprotein-receptor that affect the half-life of glycoproteins. So establishment of culture process for enhancing