Výsledky vyhledávání - "Hyun Sook Ahn"

Akademický článek

Platelet integrin αIIbβ3 plays a key role in a venous thrombogenesis mouse model

Autor: Brian D. Adair, Conroy O. Field, José L. Alonso, Jian-Ping Xiong, Shi-Xian Deng, Hyun Sook Ahn, Eivgeni Mashin, Clary B. Clish, Johannes van Agthoven, Mark Yeager, Youzhong Guo, David A. Tess, Donald W. Landry, Mortimer Poncz, M. Amin Arnaout

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Venous thrombosis (VT) is a common vascular disease associated with reduced survival and a high recurrence rate. VT is initiated by the accumulation of platelets and neutrophils at sites of endothelial cell activation. A role for platelet α

Externí odkaz: https://doaj.org/article/5cb4e38292ca4761ba710d35e201c213

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Akademický článek

Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

Autor: Brian D. Adair, José L. Alonso, Johannes van Agthoven, Vincent Hayes, Hyun Sook Ahn, I-Shing Yu, Shu-Wha Lin, Jian-Ping Xiong, Mortimer Poncz, M. Amin Arnaout

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Current inhibitors of platelet integrin αIIbβ3 cause excessive bleeding, which limited their clinical use in cardiac patients. Here the authors design pure orthosteric αIIbβ3 inhibitors that prevent platelet aggregation and thrombosis without cau

Externí odkaz: https://doaj.org/article/42565adb3ba2424890108c840e099336

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RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects

Autor: Kiwon Lee, Hyun Sook Ahn, Brian Estevez, Mortimer Poncz

Publikováno v: Blood. 141:260-270

Heterozygous defects in runt-related transcription factor 1 (RUNX1) are causative of a familial platelet disorder with associated myeloid malignancy (FPDMM). Because RUNX1-deficient animal models do not mimic bleeding disorder or leukemic risk associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69c52def3466d778158eaef1b8878b9
https://doi.org/10.1182/blood.2022017561

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RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects: Therapeutic implications

Autor: Kiwon Lee, Hyun Sook Ahn, Brian Estevez, Mortimer Poncz

Heterozygous defects in runt-related transcription factor-1 (RUNX1) are causative of a familial platelet disorder with associated myeloid malignancy (FPDMM). Since RUNX1-deficient animal models do not mimic FPDMM’s bleeding disorder or leukemic ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f94d1ce0fc2fd9cf6187560c42ae786b
https://doi.org/10.1101/2022.09.12.507354

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Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

Autor: M. Amin Arnaout, I-Shing Yu, Shu-Wha Lin, Vincent Hayes, Johannes van Agthoven, Brian D. Adair, Hyun Sook Ahn, Mortimer Poncz, José Luis Alonso, Jian-Ping Xiong

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications

A prevailing dogma is that inhibition of vascular thrombosis by antagonizing platelet integrin αIIbβ3 cannot be achieved without compromising hemostasis, thus causing serious bleeding and increased morbidity and mortality. It is speculated that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73459ec46bf2ca96677aa4912ef38249
http://link.springer.com/article/10.1038/s41467-019-13928-2

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Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia

Autor: Mortimer Poncz, Daria Madeeva, Valerie Tutwiler, Jing Dai, Douglas B. Cines, Vincent Hayes, Hyun Sook Ahn, Gowthami M. Arepally, Lubica Rauova

Publikováno v: Blood. 132:727-734

Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder initiated by antibodies to platelet factor 4 (PF4)/heparin complexes. PF4 released from platelets binds to surface glycosaminoglycans on hematopoietic and vascular cells that are hete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35d335c0690ac5dc1658ecba5d08db1
https://doi.org/10.1182/blood-2018-02-830737

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Structure-guided design of a pure orthosteric antagonist of integrin αlIbβ3 that inhibits thrombosis but not clot retraction

Autor: Hyun Sook Ahn, M. Amin Arnaout, Shu-Wha Lin, José Luis Alonso, Vincent Hayes, Jian-Ping Xiong, Brian D. Adair, Johannes van Agthoven, I-Shing Yu, Mortimer Poncz

A prevailing dogma is that effective inhibition of vascular thrombosis by therapeutic targeting of platelet integrin αIIbβ3 cannot be achieved without compromising hemostasis. The resulting serious bleeding and increased morbidity and mortality hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fdf6da6c8eba34d639273430d365c7

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