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A small molecule, (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol suppresses tumor growth via inhibition of IkappaB kinase β in colorectal cancer in vivo and in vitro

Autor: Jin Tae Hong, Hyung Ok Chun, Sung Hee Jung, Sang-Bae Han, Mi Hee Park, Jie Zheng, Hyun Ok Seo, Young Wan Ham, Byung Kook Hyun, Hee Pom Lee

Publikováno v: Oncotarget

// Jie Zheng 1, 3, * , Mi Hee Park 1, * , Hee Pom Lee 1 , Byung Kook Hyun 1 , Hyung Ok Chun 1 , Sung Hee Jung 1 , Hyun Ok Seo 1 , Young Wan Ham 2 , Sang-Bae Han 1 and Jin Tae Hong 1 1 College of Pharmacy & Medical Research Center, Chungbuk National U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b1e3c1cbcb9dd774e233965159abe5
https://doi.org/10.18632/oncotarget.20440

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CCR5 deficiency accelerates lipopolysaccharide-induced astrogliosis, amyloid-beta deposit and impaired memory function

Autor: Jin Tae Hong, Ju Hwan Kim, Yun-Bae Kim, Na Young Yun, Dae Yeon Hwang, Mi Hee Park, Ki-Wan Oh, Jae Yeon Hwang, Sang Yeon Oh, Chul Ju Hwang, Ju Kyung Song, Sang-Bae Han, Hyun Ok Seo

Publikováno v: Oncotarget

Chemokine receptors are implicated in inflammation and immune responses. Neuro-inflammation is associated with activation of astrocyte and amyloid-beta (Aβ) generations that lead to pathogenesis of Alzheimer disease (AD). Previous our study showed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a944aafc5e1b76588274bdbc153ea286
http://europepmc.org/articles/PMC4914263

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Anti-cancer effect of N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-carboxamide, a novel synthetic compound

Autor: Tae Myung Kim, Doo Won Seo, Chul Ju Hwang, Jin Tae Hong, Sun Mi Kwon, Mi Hee Park, Na Young Yoon, Hyun Ok Seo, Jae-Kyung Jung, Hyu Seok Youn, Ji Myung Yu, Bang Yeon Hwang, Heesoon Lee, Dae Hwan Kim, In Sung Chung, Sang-Bae Han, Hwan-Soo Yoo, Yu Yeon Jung

Publikováno v: Molecular Carcinogenesis. 55:659-670

Naphthofuran compounds have been known to regulate HNF 4α which is associated with proliferation, progression and metastasis of HCC. In this study, we investigated whether N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db1f10acdbf1c91d595b20c4b15b21cb
https://doi.org/10.1002/mc.22311

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Crystal transformation of a flavonoid derivative DA-6034

Autor: Young-Taek Sohn, Hyun-Ok Seo

Publikováno v: Journal of Thermal Analysis and Calorimetry. 120:749-757

DA-6034 is a synthetic flavonoid known to possess anti-inflammatory activity. DA-6034 has been found to exist in six crystal forms, one hydrate form and five solvates. Six crystal forms, one hydrate form and five solvates, of DA-6034 were prepared by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74afdd0d40b1219e1ba2f2fafe6555f9
https://doi.org/10.1007/s10973-014-4126-3

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Reducing Effect of IL-32α in the Development of Stroke Through Blocking of NF-κB, but Enhancement of STAT3 Pathways

Autor: Dong Hun Lee, Hyung-Mun Yun, Jin Tae Hong, Jin-Yi Han, Hyun Ok Seo, Do Young Yoon, Sang-Bae Han, Ki-Wan Oh, Na Young Yoon, Dong Young Choi, Chul Ju Hwang, Yu Yeon Jung

Publikováno v: Molecular Neurobiology. 51:648-660

Neuroinflammation is important for the development of several neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and stroke. Since changes of cytokine level are critical for neuroinflammation in the brain, we investigated wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09d3201dc50b1df46cb7ba0bea33c41
https://doi.org/10.1007/s12035-014-8739-0

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Guideline for Bioequivalence Studies of Controlled Release Products

Autor: Na-Ry Woo, Minjeong Kim, Sohee Kim, Hee-Won Seo, Hye-Jin Park, Choong-Yul Ahn, Mee-Ryung Ahn, Eun-Ju Lee, Soo-Youn Chung, Hyun-Ok Seo, Bo-Yeon Kim, Eun-Kyung Oh

Publikováno v: Journal of Korean Pharmaceutical Sciences. 40:63-66

The "Guidance Document for Bioequivalence Study" was revised for adding to bioequivalence studies of controlled-release products after meal(Korea Food & Drug Administration Notification #2008-22, 2008.5.7). The bioequivalence study design for control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f49e97d50c2c3a0b4e4951a2a54cefaa
https://doi.org/10.4333/kps.2010.40.1.063

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Crystal forms of ketorolac

Autor: Hyun Ok Seo, Young-Taek Sohn

Publikováno v: Archives of Pharmacal Research. 27:357-360

Four crystal forms of ketorolac have been obtained by recrystallization in organic solvents under variable conditions. Different ketorolac polymorphs and pseudopolymorph were characterized by X-ray powder diffraction crystallography (XRD), Differenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562906192f237962096a5a695d94ce2a
https://doi.org/10.1007/bf02980073

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Anti-cancer effect of N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-carboxamide, a novel synthetic compound

Autor: Sun Mi, Kwon, Yu Yeon, Jung, Chul Ju, Hwang, Mi Hee, Park, Na Young, Yoon, Tae Myung, Kim, Ji Myung, Yu, Dae Hwan, Kim, Doo Won, Seo, Hyu Seok, Youn, Hyun Ok, Seo, In Sung, Chung, Sang Bae, Han, Bang Yeon, Hwang, Hwan-Soo, Yoo, Jae-Kyung, Jung, Heesoon, Lee, Jin Tae, Hong

Publikováno v: Molecular carcinogenesis. 55(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8364b32ecdf40cab46e46597ca8c769c
https://pubmed.ncbi.nlm.nih.gov/25865242

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Memory Impairment in Estrogen Receptor α Knockout Mice Through Accumulation of Amyloid-β Peptides

Autor: Byung Kook Hyun, Ju Kyung Song, Sang-Bae Han, Dong Young Choi, Jin Tae Hong, Hyun Ok Seo, Ki-Wan Oh, Dae Yeun Hwang, Hwan-Soo Yoo, Chul Ju Hwang, Hyung-Mun Yun, Kyung-Ran Park

Publikováno v: Molecular Neurobiology

Estrogen has been known to reduce the development of Alzheimer’s disease (AD). However, exact mechanisms are not clear. We investigated whether estrogen can increase amyloid-beta (Aβ) degradation and affects Aβ-induced memory impairment in an est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25c96865bc068967c1dfaa419a55ba8
https://pubmed.ncbi.nlm.nih.gov/25128029

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Inhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition ofSTAT3-mediated NF-kappa B activation in cultured astrocytes andmicroglial BV-2 cells

Autor: Suk-Young Song, Chul Ju Hwang, Sang-Bae Han, Jin Tae Hong, Young Wan Ham, Joo Hwan Kim, Hyun Ok Seo, Chang Hyun Sok, Yu Yeon Jung, Sang Min Lee, Bang Yeon Hwang, Hee Peom Lee, Dong Young Choi, Byung Kook Hyun

Publikováno v: JOURNAL OF NEUROINFLAMMATION(11)
Journal of Neuroinflammation

Background ent-Sauchinone is a polyphenolic compound found in plants belonging to the lignan family. ent-Sauchinone has been shown to modulate the expression of inflammatory factors through the nuclear factor-kappa B (NF-κB) signaling pathway. It is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ce0fffd02f9f7d25c993c00b736cb7
http://open-repository.kisti.re.kr/cube/handle/open_repository/480788.do

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