Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Hyun Chul Koh"'
Autor:
Tae Woo Kim, Younghye Moon, Kyungjin Kim, Jeong Eun Lee, Hyun Chul Koh, Im Joo Rhyu, Hyun Kim, Woong Sun
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25346 (2011)
Parkinson's disease (PD) is a common, late-onset movement disorder with selective degeneration of dopaminergic (DA) neurons in the substantia nigra (SN). Although the neurotoxin 6-hydroxydopamine (6-OHDA) has been used to induce progressive degenerat
Externí odkaz:
https://doaj.org/article/98830bd1f08f4add94474fffdf09283d
Autor:
Hyun Chul Koh, Aeri Park
Publikováno v:
Archives of Toxicology. 93:1239-1253
Autophagy and apoptosis are the major types of cell death in pesticide-induced neurotoxicity, and autophagy is known to play a role in cell protection by inhibiting apoptosis. In this study, we characterized the relationship between autophagy and apo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe32ec51a459a645b664b6b815e3568
https://doi.org/10.1007/s00204-019-02424-7
https://doi.org/10.1007/s00204-019-02424-7
Autor:
Ramu Gopalappa, Arun Pandian Chandrasekaran, Myungjae Song, Saba Haq, Suresh Ramakrishna, Hyun Chul Koh, Soumyadip Das
Publikováno v:
Archives of Pharmacal Research. 41:911-920
Targeted genome editing by clustered regularly interspaced short palindromic repeats (CRISPR-Cas9) raised concerns over off-target effects. The use of double-nicking strategy using paired Cas9 nickase has been developed to minimize off-target effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f18c1bb02b8ee5db612fcdf8aefcc7a
https://doi.org/10.1007/s12272-018-1042-2
https://doi.org/10.1007/s12272-018-1042-2
Autor:
Hong Ju Kim, Hyun Chul Koh
Publikováno v:
Food and Chemical Toxicology. 158:112706
α-Synuclein, which is associated with Parkinson's disease, is cleared by the ubiquitin–proteasome system and autophagy lysosome system. Chaperon-mediated autophagy (CMA) and macroautophagy are major subtypes of autophagy and play a critical role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4347f7b0d819fee849b4b00804588d09
https://doi.org/10.1016/j.fct.2021.112706
https://doi.org/10.1016/j.fct.2021.112706
Autor:
Si Yeon Park, Hyun Chul Koh
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 137
Upon mitochondrial stress, PINK1 and Parkin cooperatively mediate a response that removes damaged mitochondria. In addition to the PINK1/Parkin pathway, the FUNDC1, mitophagy receptor regulates mitochondrial clearance. It is not clear whether these s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1100531ca06a453f7cebe23b5af10b3
https://pubmed.ncbi.nlm.nih.gov/32001317
https://pubmed.ncbi.nlm.nih.gov/32001317
Autor:
Jae W Choi, Jinu Lee, Hui K Kim, Jin Wu Nam, Myungjae Song, Young Mook Kang, A. Vipin Menon, Hyun Chul Koh, Soobin Jung, Hyongbum Kim, Eui-Jeon Woo
Publikováno v:
Nature Methods. 14:153-159
CRISPR from Prevotella and Francisella 1 (Cpf1) is an effector endonuclease of the class 2 CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated proteins) gene editing system. We developed a method for evaluating Cpf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a166a6aed234ef3b0c2686aefbde992
https://doi.org/10.1038/nmeth.4104
https://doi.org/10.1038/nmeth.4104
Autor:
Seyoung Ahn, Takbum Ohn, Jungyun Park, Aravinth Kumar Jayabalan, Hyun Chul Koh, Jungwook Hwang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859:896-905
Nonsense-mediated mRNA decay (NMD) modulates the level of mRNA harboring a premature termination codon (PTC) in a translation-dependent manner. Inhibition of translation is known to impair NMD; however, few studies have investigated the correlation b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0912f08c872276dc4ec79e0da87169bb
https://doi.org/10.1016/j.bbagrm.2015.12.006
https://doi.org/10.1016/j.bbagrm.2015.12.006
Publikováno v:
NeuroToxicology. 51:145-157
Recent studies have demonstrated that dynamin-related protein 1 (Drp1), a mitochondrial fission protein, mediates mitochondria-dependent apoptosis through mitochondrial division. However, little is known about the mechanism by which Drp1 modulates ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ab08339e21f833a1dd650a9de06d09
https://doi.org/10.1016/j.neuro.2015.10.008
https://doi.org/10.1016/j.neuro.2015.10.008
Publikováno v:
Environmental Toxicology. 32:109-121
The autophagy pathway can be induced and upregulated in response to intracellular reactive oxygen species (ROS). In this study, we explored a novel pharmacotherapeutic approach involving the regulation of autophagy to prevent deltamethrin (DLM) neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb7e1fb872ece565e5be05021a073ba
https://doi.org/10.1002/tox.22216
https://doi.org/10.1002/tox.22216
Autor:
Min-Kyoung Paik, Kyung-Hun Park, Jae Hyeon Park, Youn Sun Park, Hyun Chul Koh, Je-Bong Lee, Mi-Hye Jeong
Publikováno v:
Journal of Applied Toxicology. 36:10-23
Oxidative stress and inflammatory responses have been identified as key elements of neuronal cell apoptosis. In this study, we investigated the mechanisms by which inflammatory responses contribute to apoptosis in human neuroblastoma SH-SY5Y cells tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42b90319a257a50e2d3bb266a292c858
https://doi.org/10.1002/jat.3136
https://doi.org/10.1002/jat.3136