Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Hyun‐Jeong Ko"'
Autor:
Mahesh Pandit, Yun-Seo Kil, Jae-Hee Ahn, Ram Hari Pokhrel, Ye Gu, Sunil Mishra, Youngjoo Han, Yung-Taek Ouh, Ben Kang, Myeong Seon Jeong, Jong-Oh Kim, Joo-Won Nam, Hyun-Jeong Ko, Jae-Hoon Chang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Programmed cell death protein 1 (PD-1), expressed on tumor-infiltrating T cells, is a T cell exhaustion marker. The mechanisms underlying PD-1 upregulation in CD4 T cells remain unknown. Here we develop nutrient-deprived media and a conditio
Externí odkaz:
https://doaj.org/article/961d3f43245b4a6f9d6d179897930d26
Autor:
Hyunjin Jeong, Eun-Hye Hong, Jae-Hee Ahn, Jaewon Cho, Jae-Hyeon Jeong, Chae-Won Kim, Byung-Il Yoon, Ja Hyun Koo, Yun-Yong Park, Yoon Mee Yang, Takao Iwawaki, Bruce A. Vallance, Sun-Young Chang, Hyun-Jeong Ko
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 2, Pp 401-412 (2023)
Inflammatory bowel disease: A protective enzyme in intestinal goblet cells Studies of inflammatory bowel disease (IBD) in mice reveal the role of an enzyme that assists the degradation of mis-folded proteins in the ‘goblet’ cells involved in prod
Externí odkaz:
https://doaj.org/article/174801680b7743fc83f22ec68a75c90b
Autor:
Eun-Bin Kwon, Wei Li, Young Soo Kim, Buyun Kim, Hwan-Suck Chung, Younghoon Go, Hyun-Jeong Ko, Jae-Hyoung Song, Young Ho Kim, Chun Whan Choi, Jang-Gi Choi
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 1, Pp 174-191 (2023)
The development of drug-resistant influenza and new pathogenic virus strains underscores the need for antiviral therapeutics. Currently, neuraminidase (NA) inhibitors are commonly used antiviral drugs approved by the US Food and Drug Administration (
Externí odkaz:
https://doaj.org/article/7c046e5532d14f3ca54a8fdd2001d638
Autor:
Jae-Hyoung Song, Seo-Hyeon Mun, Heejung Yang, Yong Soo Kwon, Seong-Ryeol Kim, Min-young Song, Youngwook Ham, Hwa-Jung Choi, Won-Jin Baek, Sungchan Cho, Hyun-Jeong Ko
Publikováno v:
Viruses, Vol 16, Iss 1, p 16 (2023)
Enterovirus A71 (EV71), coxsackievirus A16 (CVA16), and coxsackievirus B3 (CVB3) are pathogenic members of the Picornaviridae family that cause a range of diseases, including severe central nervous system complications, myocarditis, and pancreatitis.
Externí odkaz:
https://doaj.org/article/a6f0f3865d9a4132a499f8a708cf6788
Autor:
Ram Hari Pokhrel, Suman Acharya, Jae-Hee Ahn, Ye Gu, Mahesh Pandit, Jong-Oh Kim, Yun-Yong Park, Ben Kang, Hyun-Jeong Ko, Jae-Hoon Chang
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-15 (2021)
Abstract Background AMP-activated protein kinase (AMPK) is a metabolic sensor that maintains energy homeostasis. AMPK functions as a tumor suppressor in different cancers; however, its role in regulating antitumor immunity, particularly the function
Externí odkaz:
https://doaj.org/article/174c1debff074d1ea4f04e0abaa734a8
Publikováno v:
Organoid, Vol 2 (2022)
In vitro experiments have been widely used for more than a century to elucidate molecular mechanisms in cells and pathogen-host interactions, as well as for drug screening. Cell lines have been modified to reflect researchers’ specific purposes, an
Externí odkaz:
https://doaj.org/article/6b49d95f750747c78a8c550e33e1e812
Publikováno v:
ACS Omega, Vol 5, Iss 48, Pp 31126-31136 (2020)
Externí odkaz:
https://doaj.org/article/cb46e0d2b36742228d7dedc3bede9678
Autor:
Sang-Uk Seo, Jae-Hyeon Jeong, Bum-Seo Baek, Je-Min Choi, Youn Soo Choi, Hyun-Jeong Ko, Mi-Na Kweon
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Acute lung injury (ALI) results in acute respiratory disease that causes fatal respiratory diseases; however, little is known about the incidence of influenza infection in ALI. Using a ALI-mouse model, we investigated the pro-inflammatory cytokine re
Externí odkaz:
https://doaj.org/article/aac5e73db63245e3922b5a876de20989
Autor:
Young-In Kim, Eun-Je Yi, Young-Dae Kim, A Reum Lee, Jiwoung Chung, Hae Chan Ha, Joong Myung Cho, Seong-Ryeol Kim, Hyun-Jeong Ko, Jae-Hee Cheon, Yong Rae Hong, Sun-Young Chang
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Intestinal epithelial cells are adapted in mucosal hypoxia and hypoxia-inducible factors in these cells can fortify barrier integrity to support mucosal tissue healing. Here we investigated whether hypoxia-related pathways could be proposed as potent
Externí odkaz:
https://doaj.org/article/8fd784746bea4bcc974bd31544f5242a
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Autophagy is a lysosomal self-digestion pathway that maintains internal homeostasis inside cells and critical process by which the innate immune system eliminates intracellular bacteria. In this study, we showed that stimulation of toll-like receptor
Externí odkaz:
https://doaj.org/article/e936930da14747a2ab9ef80aeeba4a32