Výsledky vyhledávání - "Hyuk Jean Kwon"

Abstract 4990: Dual inhibitor of ACVR1 and MEK 1/2 E6201 and PI3K/mTOR inhibitor paxalisib synergistically inhibit cell growth in DMG

Autor: Hyuk Jean Kwon, Abigail Tindall, Charles Eberhart, Jeffrey Rubens, Eric Raabe

Publikováno v: Cancer Research. 83:4990-4990

Diffuse midline glioma (DMG) is an aggressive pediatric glioma with no curative treatment options. Mutation in MAPK pathway is common in many DMG tumors, however, has not been largely explored before. E6201 is a dual inhibitor of ACVR1 and MEK 1/2. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c33a4f88bd8fbecf7f74ad3e83f35ee1
https://doi.org/10.1158/1538-7445.am2023-4990

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Abstract 3987: Brain penetrant HDAC and PI3K/mTOR inhibitors synergize to induce DIPG cell death

Autor: Katherine Barnett, Hyuk Jean Kwon, Orlandi Novak, Charles Eberhart, Eric Raabe

Publikováno v: Cancer Research. 82:3987-3987

Diffuse intrinsic pontine glioma (DIPG) is a universally fatal pediatric brain tumor. We have previously shown that the brain penetrant class 1 HDAC inhibitor RG2833 (RGFP109) inhibits cell growth (MTS assay for HSJD007 p=0.0004, JHH-DIPG1 p=0.001, S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72e525ba8a7a4d3208a78e84ec40118b
https://doi.org/10.1158/1538-7445.am2022-3987

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