Výsledky vyhledávání - "Hyuk‐Woo Lee"

Akademický článek

A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway

Autor: Sae-Bom Yoon, Hyowon Hong, Hee-Jong Lim, Ji Hye Choi, Yoon Pyo Choi, Seong Wook Seo, Hyuk Woo Lee, Chong Hak Chae, Woo-Kyu Park, Hyun Young Kim, Daeyoung Jeong, Tran Quang De, Chang-Seon Myung, Heeyeong Cho

Publikováno v: Acta Pharmaceutica Sinica B, Vol 13, Iss 3, Pp 1093-1109 (2023)

Interleukin-1 receptor-associated kinase 4 (IRAK4) is a pivotal enzyme in the Toll-like receptor (TLR)/MYD88 dependent signaling pathway, which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphom

Externí odkaz: https://doaj.org/article/06e3ac574c0849ed8c4b61044cdc2a36

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Structure–Activity Relationships of Truncated 1′-Homologated Carbaadenosine Derivatives as New PPARγ/δ Ligands: A Study on Sugar Puckering Affecting Binding to PPARs

Autor: Young Eum Hyun, Seungchan An, Minjae Kim, In Guk Park, Sanghee Yoon, Hafiz Muhammad Ahmad Javaid, Thi Ngoc Lan Vu, Gyudong Kim, Hongseok Choi, Hyuk Woo Lee, Minsoo Noh, Joo Young Huh, Sun Choi, Hong-Rae Kim, Lak Shin Jeong

Publikováno v: Journal of Medicinal Chemistry. 66:4961-4978

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe91b95695d9dffb604b4ac6187c6d1a
https://doi.org/10.1021/acs.jmedchem.2c02071

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Akademický článek

Discovery of a Novel Template, 7-Substituted 7-Deaza-4′-Thioadenosine Derivatives as Multi-Kinase Inhibitors

Autor: Karishma K. Mashelkar, Woong Sub Byun, Hyejin Ko, Kisu Sung, Sushil K. Tripathi, Seungchan An, Yun A Yum, Jee Youn Kwon, Minjae Kim, Gibae Kim, Eun-Ji Kwon, Hyuk Woo Lee, Minsoo Noh, Sang Kook Lee, Lak Shin Jeong

Publikováno v: Pharmaceuticals, Vol 14, Iss 12, p 1290 (2021)

The development of anticancer drugs remains challenging owing to the potential for drug resistance. The simultaneous inhibition of multiple targets involved in cancer could overcome resistance, and these agents would exhibit higher potency than singl

Externí odkaz: https://doaj.org/article/6a327eedf4e041f083764e0fd7c848a5

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In Silico Discovery of 5′-Modified 7-Deoxy-7-ethynyl-4′-thioadenosine as a HASPIN Inhibitor and Its Synergistic Anticancer Effect with the PLK1 Inhibitor

Autor: Eun-Ji Kwon, Karishma K. Mashelkar, Juhee Seo, Yoon-Ze Shin, Kisu Sung, Sung Chul Jang, Sang Won Cheon, Haeseung Lee, Hyuk Woo Lee, Gyudong Kim, Byung Woo Han, Sang Kook Lee, Lak Shin Jeong, Hyuk-Jin Cha

Publikováno v: ACS Central Science.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f079405c93a8b9673ea1681fcd5a7aeb
https://doi.org/10.1021/acscentsci.3c00332

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Supplementary Figure Legends 1-4 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

Autor: Lijun Jia, Jie Liu, Lak Shin Jeong, Yi Sun, Xiangdong Wang, Jing Yi, Yiwei Chu, Lijun Wu, Jing Qian, Chan Ding, Yongfu Pan, Dongqin Yang, Lingyan Wang, Lihui Li, Hyuk Woo Lee, Guangyang Yu, Zhongguang Luo

PDF file - 94K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59845efcc6a9bf1c26b50d4bad8c6c3c
https://doi.org/10.1158/0008-5472.22393787

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Supplementary Figure 1 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

PDF file - 1.2MB, Induction of cell cycle arrest and apoptosis by MLN4924 in Hep G2 cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161d45cc6d1254a143e245c124dab73e
https://doi.org/10.1158/0008-5472.22393799.v1

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Supplementary Figure 4 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

PDF file - 924K, No obvious dysfunction of liver, kidney or muscle of animals was observed post MLN4924 treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146eec9010616a04bdea5d1f4595156f
https://doi.org/10.1158/0008-5472.22393790.v1

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Supplementary Figure 3 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

PDF file - 1MB, MLN4924 induced more apoptosis in MEF-Atg7-KO compared to MEF-Atg7-WT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f686327088c930df302d520ae7b1ff
https://doi.org/10.1158/0008-5472.22393793

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Supplementary Figure 2 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Induces Autophagy and Apoptosis to Suppress Liver Cancer Cell Growth

PDF file - 979K, MLN4924-induced autophagy was partially rescued by N-Acetyl-L-cysteine (NAC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7eeca99f58f43f09bcc3afdbef38604
https://doi.org/10.1158/0008-5472.22393796

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Anticancer activity of IRAK-4 inhibitors against canine lymphoid malignancies

Autor: Jun‐Hyeong Park, Jeong‐Hwa Lee, Ju‐Hyun An, Chong‐Woo Park, Yoon‐Pyo Choi, Seong‐Wook Seo, Hyuk‐Woo Lee, Hwa‐Young Youn

Publikováno v: Veterinary and comparative oncologyREFERENCES. 20(3)

The interleukin-1 receptor-related kinase 4 (IRAK4), downstream of myd88, plays an essential role in hyperactive TLR signalling seen in some B-cell lymphomas. In particular, efficient IRAK4 inhibitors of activated B-cell subtype of human diffuse larg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b65beaf909e52bf9bde0d82886e1a9
https://pubmed.ncbi.nlm.nih.gov/35340094

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