Autophagy in drusen biogenesis secondary to age-related macular degeneration.

Autor: Hyttinen JMT; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Koskela A; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Blasiak J; Faculty of Medicine, Collegium Medicum, Mazovian Academy in Plock, Plock, Poland., Kaarniranta K; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Molecular Genetics, University of Lodz, Lodz, Poland.; Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland.

Publikováno v: Acta ophthalmologica [Acta Ophthalmol] 2024 Nov; Vol. 102 (7), pp. 759-772. Date of Electronic Publication: 2024 Aug 01.

Only IL-1β release is inflammasome-dependent upon ultraviolet B irradiation although IL-18 is also secreted.

Autor: Korhonen E; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.; HUSLAB, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Piippo N; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Hytti M; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Hyttinen JMT; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Kaarniranta K; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland., Kauppinen A; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 May; Vol. 34 (5), pp. 6437-6448. Date of Electronic Publication: 2020 Mar 19.

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice.

Autor: Tamminen T; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland., Koskela A; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland., Toropainen E; School of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland., Gurubaran IS; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland., Winiarczyk M; Department of Vitreoretinal Surgery, Medical University of Lublin, Poland., Liukkonen M; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland., Paterno JJ; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.; Department of Ophthalmology, Kuopio University Hospital, P.O. Box 100, FI-70029 KYS Kuopio, Finland., Lackman P; Eevia Health Oy, FI-60100 Seinäjoki, Finland., Sadeghi A; School of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland., Viiri J; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland., Hyttinen JMT; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland., Koskelainen A; Department of Neuroscience and Biomedical Engineering, Aalto University, FI-00067 Aalto, Finland., Kaarniranta K; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.; Department of Ophthalmology, Kuopio University Hospital, P.O. Box 100, FI-70029 KYS Kuopio, Finland.

Publikováno v: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2021 Dec 07; Vol. 2021, pp. 8028427. Date of Electronic Publication: 2021 Dec 07 (Print Publication: 2021).

Oxidative Stress and Mitochondrial Damage in Dry Age-Related Macular Degeneration Like NFE2L2/PGC-1α   ^-/- Mouse Model Evoke Complement Component C5a Independent of C3.

Autor: Sridevi Gurubaran I; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, 70210 Kuopio, Finland., Heloterä H; Department of Ophthalmology, Roche Oy, 02100 Espoo, Finland., Marry S; The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Queens University Belfast, Belfast BT9 7BL, UK., Koskela A; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, 70210 Kuopio, Finland., Hyttinen JMT; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, 70210 Kuopio, Finland., Paterno JJ; Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, 70210 Kuopio, Finland., Urtti A; Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, 70210 Kuopio, Finland., Chen M; The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Queens University Belfast, Belfast BT9 7BL, UK., Xu H; The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Queens University Belfast, Belfast BT9 7BL, UK., Kauppinen A; Faculty of Health Sciences, School of Pharmacy, University of Eastern Finland, 70210 Kuopio, Finland., Kaarniranta K; Department of Ophthalmology, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.

Publikováno v: Biology [Biology (Basel)] 2021 Jul 04; Vol. 10 (7). Date of Electronic Publication: 2021 Jul 04.

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice.

Autor: Blasiak J; Department of Molecular Genetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland., Koskela A; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland., Pawlowska E; Department of Orthodontics, Medical University of Lodz, 92-217 Lodz, Poland., Liukkonen M; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland., Ruuth J; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland., Toropainen E; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland., Hyttinen JMT; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland., Viiri J; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland., Eriksson JE; Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.; Cell Biology, Faculty of Science and Technology, Åbo Akademi University, 20500 Turku, Finland., Xu H; The Wellcome-Wolfson Institute of Experimental Medicine Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Chen M; The Wellcome-Wolfson Institute of Experimental Medicine Queen's University Belfast, 97 Lisburn Rd, Belfast BT9 7BL, UK., Felszeghy S; Institute of Biomedicine, University of Eastern Finland, Yliopistonranta 1 A, 70211 Kuopio, Finland.; Institute of Dentistry, University of Eastern Finland, Yliopistonranta 1 C, 70211 Kuopio, Finland., Kaarniranta K; Department of Ophthalmology, University of Eastern Finland, 70210 Kuopio, Finland.; Department of Ophthalmology, Kuopio University Hospital, 70210 Kuopio, Finland.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Feb 08; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 08.