Antitumor Activity of Nanoparticles Loaded with PHT-427, a Novel AKT/PDK1 Inhibitor, for the Treatment of Head and Neck Squamous Cell Carcinoma

Autor: Joaquín Yanes-Díaz, Raquel Palao-Suay, María Rosa Aguilar, Juan Ignacio Riestra-Ayora, Antonio Ferruelo-Alonso, Luis Rojo del Olmo, Blanca Vázquez-Lasa, Ricardo Sanz-Fernández, Carolina Sánchez-Rodríguez

Publikováno v: Pharmaceutics, Vol 13, Iss 8, p 1242 (2021)

Currently, new treatments are required to supplement the current standard of care for head and neck squamous cell carcinoma (HNSCC). The phosphatidylinositol3-kinase (PI3K) signaling pathway is commonly altered and activated in HNSCC. PHT-427 is a du

Externí odkaz: https://doaj.org/article/3abf5b0ff45144939b20dfbbef395d22

Antitumor Activity of Nanoparticles Loaded with PHT-427, a Novel AKT/PDK1 Inhibitor, for the Treatment of Head and Neck Squamous Cell Carcinoma

Autor: Raquel Palao-Suay, Ricardo Sanz-Fernández, Antonio Ferruelo-Alonso, Blanca Vázquez-Lasa, Carolina Sánchez-Rodríguez, María Rosa Aguilar, Luis Rojo Del Olmo, Joaquin Yanes-Diaz, Juan Riestra-Ayora

Publikováno v: Pharmaceutics
Volume 13
Issue 8
Pharmaceutics, Vol 13, Iss 1242, p 1242 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname

Currently, new treatments are required to supplement the current standard of care for head and neck squamous cell carcinoma (HNSCC). The phosphatidylinositol3-kinase (PI3K) signaling pathway is commonly altered and activated in HNSCC. PHT-427 is a du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ffa18acd52fad396f620914afd3ce29

Paclitaxel-loaded polymeric nanoparticles based on a-tocopheryl succinate for the treatment of head and neck squamous cell carcinoma: in vivo murine model

Autor: Joaquin Yanes-Diaz, Raquel Palao-Suay, Juan Riestra-Ayora, Carolina Sánchez-Rodríguez, Ana Martín-Hita, María Rosa Aguilar, Ricardo Sanz-Fernández

Publikováno v: ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
Drug Delivery
article-version (VoR) Version of Record
Digital.CSIC. Repositorio Institucional del CSIC
instname
Drug Delivery, Vol 28, Iss 1, Pp 1376-1388 (2021)

The prognosis of patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC) is generally poor. New treatments are required to supplement the current standard of care. Paclitaxel (PTX), an effective chemotherapeutic for HNSCC, ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8118d240325e2585cf657d69bf52812e
http://hdl.handle.net/11268/10228

α-Tocopheryl Succinate-Based Polymeric Nanoparticles for the Treatment of Head and Neck Squamous Cell Carcinoma

Autor: Sergio Martín-Saldaña, Ricardo Sanz-Fernández, Carolina Sánchez-Rodríguez, Raquel Palao-Suay, Laura Rodrigáñez, María Rosa Aguilar, Julio San Román

Publikováno v: Biomolecules
Biomolecules, Vol 8, Iss 3, p 97 (2018)
ABACUS. Repositorio de Producción Científica
Universidad Europea (UEM)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Volume 8
Issue 3
Digital.CSIC. Repositorio Institucional del CSIC
instname

The aim of this work is to study, in an in vitro head and neck squamous cell carcinomas model the anti-angiogenic and anti-migratory properties of self-assembled polymeric nanoparticles (NPs) with demonstrated selective anticancer activity. The NPs a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3edea7bf00906131f3334230ad40dfd
https://pubmed.ncbi.nlm.nih.gov/30235821

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