Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Hypoglycemic Agents/administration & dosage"'
Autor:
Helen M. Colhoun, Scott S. Emerson, Steve Marso, G. Kees Hovingh, Kirstine Brown-Frandsen, Steven E. Kahn, John E. Deanfield, Robert F. Kushner, A. Michael Lincoff, Henrik Ravn, Jorge Plutzky, Ildiko Lingvay, Donna H. Ryan, Anders G. Holst, Marianne O. L. Gronning
Publikováno v:
American heart journal, 229, 61-69. Mosby Inc.
Ryan, D H, Lingvay, I, Colhoun, H M, Deanfield, J, Emerson, S S, Kahn, S E, Kushner, R F, Marso, S, Plutzky, J, Brown-Frandsen, K, Gronning, M O L, Hovingh, G K, Holst, A G, Ravn, H & Lincoff, A M 2020, ' Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design ', American Heart Journal, vol. 229, pp. 61-69 . https://doi.org/10.1016/j.ahj.2020.07.008
Ryan, D H, Lingvay, I, Colhoun, H M, Deanfield, J, Emerson, S S, Kahn, S E, Kushner, R F, Marso, S, Plutzky, J, Brown-Frandsen, K, Gronning, M O L, Hovingh, G K, Holst, A G, Ravn, H & Lincoff, A M 2020, ' Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design ', American Heart Journal, vol. 229, pp. 61-69 . https://doi.org/10.1016/j.ahj.2020.07.008
Cardiovascular disease (CVD) is a major cause of morbidity and mortality. Although it has been widely appreciated that obesity is a major risk factor for CVD, treatments that produce effective, durable weight loss and the impact of weight reduction i
Autor:
Michael C. Riddell, Louisa van den Boom, Simon Heller, Peter G. Jacobs, Richard M. Bergenstal, Pieter Gillard, Carine de Beaufort, Martin Tauschmann, Max L. Eckstein, Tadej Battelino, Othmar Moser, Chantal Mathieu, Dessi P. Zaharieva, Richard M. Bracken, Harald Sourij, Peter Adolfsson, Carmel E. Smart, Nick Oliver, Christoph Stettler, Hood Thabit, Rémi Rabasa-Lhoret, Tim Heise, Julia K. Mader, Eda Cengiz, Lalantha Leelarathna, Aaron J. Kowalski, Kirsten Nørgaard, Bruce A. Buckingham, Asma Deeb, Emma G. Wilmot
Publikováno v:
Pediatric Diabetes
Moser, Othmar; Riddell, Michael C; Eckstein, Max L; Adolfsson, Peter; Rabasa-Lhoret, Rémi; van den Boom, Louisa; Gillard, Pieter; Nørgaard, Kirsten; Oliver, Nick S; Zaharieva, Dessi P; Battelino, Tadej; de Beaufort, Carine; Bergenstal, Richard M; Buckingham, Bruce; Cengiz, Eda; Deeb, Asma; Heise, Tim; Heller, Simon; Kowalski, Aaron J; Leelarathna, Lalantha; ... (2020). Glucose management for exercise using continuous glucose monitoring (CGM) and intermittently scanned CGM (isCGM) systems in type 1 diabetes: position statement of the European Association for the Study of Diabetes (EASD) and of the International Society for Pediatric and Adolescent Diabetes (ISPAD) endorsed by JDRF and supported by the American Diabetes Association (ADA). Pediatric diabetes, 21(8), pp. 1375-1393. Wiley 10.1111/pedi.13105
Diabetolegia
Moser, Othmar; Riddell, Michael C; Eckstein, Max L; Adolfsson, Peter; Rabasa-Lhoret, Rémi; van den Boom, Louisa; Gillard, Pieter; Nørgaard, Kirsten; Oliver, Nick S; Zaharieva, Dessi P; Battelino, Tadej; de Beaufort, Carine; Bergenstal, Richard M; Buckingham, Bruce; Cengiz, Eda; Deeb, Asma; Heise, Tim; Heller, Simon; Kowalski, Aaron J; Leelarathna, Lalantha; ... (2020). Glucose management for exercise using continuous glucose monitoring (CGM) and intermittently scanned CGM (isCGM) systems in type 1 diabetes: position statement of the European Association for the Study of Diabetes (EASD) and of the International Society for Pediatric and Adolescent Diabetes (ISPAD) endorsed by JDRF and supported by the American Diabetes Association (ADA). Pediatric diabetes, 21(8), pp. 1375-1393. Wiley 10.1111/pedi.13105
Diabetolegia
Physical exercise is an important component in the management of type 1 diabetes across the lifespan. Yet, acute exercise increases the risk of dysglycaemia, and the direction of glycaemic excursions depends, to some extent, on the intensity and dura
Autor:
D. Elleri, Malgorzata E. Wilinska, Sabine E. Hofer, Thomas R. Pieber, Fiona Campbell, Sabine Arnolds, Carine de Beaufort, Amy Criego, David B. Dunger, Thomas Kapellen, Elke Fröhlich-Reiterer, Roman Hovorka, Birgit Rami-Merhar, Martin Tauschmann, KidsAP Consortia, Lalantha Leelarathna, Hood Thabit, Carlo L. Acerini, Klemen Dovc, Viral N. Shah, Mark L. Evans, Charlotte K. Boughton, Richard M. Bergenstal, Janet M. Allen, Judy Sibayan, Lia Bally
Publikováno v:
Diabetes Care
APCam11 Consortium, AP@home Consortium & KidsAP Consortia 2019, ' Young Children Have Higher Variability of Insulin Requirements : Observations During Hybrid Closed-Loop Insulin Delivery ', Diabetes Care, vol. 42, no. 7, pp. 1344-1347 . https://doi.org/10.2337/dc18-2625
APCam11 Consortium, AP@home Consortium & KidsAP Consortia 2019, ' Young Children Have Higher Variability of Insulin Requirements : Observations During Hybrid Closed-Loop Insulin Delivery ', Diabetes Care, vol. 42, no. 7, pp. 1344-1347 . https://doi.org/10.2337/dc18-2625
OBJECTIVE: To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS: We retrospectively analyzed data from hybrid closed-loop studies involving young children (1-6 years old,
Autor:
Christoph Engel, Konrad Reinhart, Andreas Meier-Hellmann, Max Ragaller, Frank Bloos, Charles Natanson, Rolf Rossaint, Onnen Moerer, Stefan John, Matthias Gruendling, Martin Schaefer, Norbert Weiler, Christiane S. Hartog, Tobias Welte, Frank M. Brunkhorst, Markus Loeffler, Ulrich Jaschinski, Stefan Grond, Peter M. Kern, Michael Oppert, Derk Olthoff, Michael Kiehntopf, Evelyn Kuhnt
BACKGROUND: The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0e8bcd00a1b3dc959334af512d3eb6
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/81967
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/81967
Autor:
Brown SA, Kovatchev BP, Raghinaru D, Lum JW, Buckingham BA, Kudva YC, Laffel LM, Levy CJ, Pinsker JE, Wadwa RP, Dassau E, Doyle FJ, Anderson SM, Church MM, Dadlani V, Ekhlaspour L, Forlenza GP, Isganaitis E, Lam DW, Kollman C, Beck RW, Trial Research Group. iDCL
Publikováno v:
New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2019, 381 (18), pp.1707-1717. ⟨10.1056/NEJMoa1907863⟩
New England Journal of Medicine, Massachusetts Medical Society, 2019, 381 (18), pp.1707-1717. ⟨10.1056/NEJMoa1907863⟩
Closed-loop systems that automate insulin delivery may improve glycemic outcomes in patients with type 1 diabetes.In this 6-month randomized, multicenter trial, patients with type 1 diabetes were assigned in a 2:1 ratio to receive treatment with a cl
Autor:
Donal O’Shea, Aonghus O’ Loughlin, Allys Guerandel, Brendon Stubbs, John Lally, Fiona Gaughran
Publikováno v:
Lally, J, O’ Loughlin, A, Stubbs, B, Guerandel, A, O’Shea, D & Gaughran, F 2018, ' Pharmacological management of diabetes in severe mental illness : a comprehensive clinical review of efficacy, safety and tolerability ', Expert review of clinical pharmacology, vol. 11, no. 4, pp. 411-424 . https://doi.org/10.1080/17512433.2018.1445968
INTRODUCTION: The increased prevalence of Type 2 diabetes mellitus (T2DM) in severe mental illness (SMI) contributes to increased cardiovascular morbidity and reduced life expectancy for people with SMI. Areas covered: In the present clinical review,
Autor:
Lars C. Gormsen, Mette Marie Hougaard Christensen, Steen Jakobsen, Jonas Jensen, Jørgen Frøkiær, Niels Jessen, Kim Brøsen, Ole Lajord Munk, Mikkel H. Vendelbo, Elias Immanuel Ordell Sundelin
Publikováno v:
Sundelin, E, Gormsen, L C, Jensen, J B, Vendelbo, M H, Jakobsen, S, Munk, O L, Christensen, M M H, Brøsen, K, Frøkiaer, J & Jessen, N 2017, ' Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans ', Clinical Pharmacology and Therapeutics, vol. 102, no. 5, pp. 841-848 . https://doi.org/10.1002/cpt.701
Sundelin, E I O, Gormsen, L C, Jensen, J B, Vendelbo, M H, Jakobsen, S, Munk, O L, Christensen, M M H, Brøsen, K, Frøkiaer, J & Jessen, N 2017, ' Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans ', Clinical Pharmacology and Therapeutics, vol. 102, no. 5, pp. 841-848 . https://doi.org/10.1002/cpt.701
Sundelin, E I O, Gormsen, L C, Jensen, J B, Vendelbo, M H, Jakobsen, S, Munk, O L, Christensen, M M H, Brøsen, K, Frøkiaer, J & Jessen, N 2017, ' Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans ', Clinical Pharmacology and Therapeutics, vol. 102, no. 5, pp. 841-848 . https://doi.org/10.1002/cpt.701
Metformin has been used successfully to treat type 2 diabetes for decades. However, the efficacy of the drug varies considerably from patient to patient and this may in part be due to its pharmacokinetic properties. The aim of this study was to exami
Autor:
Petrie, John R., Chaturvedi, Nish, Ford, Ian, Hramiak, Irene, Hughes, Alun D., Jenkins, Alicia J., E. Klein, Barbara, Klein, Ron, Ooi, Teik Chye, Rossing, Peter, Sattar, Naveed, Stehouwer, Coen D. A., Colhoun, Helen M., Ford, I, Kean, S, Thomson, E, Gillespie, L, Gibb, J, Greenlaw, N, Hramiak, I, Keech, A, Jenkins, A, Chaturvedi, N, Hughes, A, March, K, Coady, E, Tillin, T, Bots, M, Klein, R, Klein, B, Dreyer, J, Jan, T, Meuer, S, Murach, D, Sheffy, Koby, Lusky, Ravit, Peleg, S, Petrie, J, Colhoun, H, Shore, A, Carty, D, Donnan, P, Witham, M, Adler, A, Lonn, E, Rauchhaus, P, Lindsay, R, Brouwers, M, Van‐Melckebeke, J, Hamill, T, Cuthbertson, L, Murray, A, Jolly, L, Miller, E, Sattar, N, Hair, J, Bell, A, Carmichael, S, Douglas, E, Surtees, P, Dinnett, E, Allan, J, Watson, C, McLaughlin, M, Brindley, G, Smillie, E, Motherwell, D, MacDonald, S, Ellis, P, Stuart, D, Travers, M, Brearley, S, Greig, L, Haw, J
Publikováno v:
Petrie, J R, Chaturvedi, N, Ford, I, Hramiak, I, Hughes, A D, Jenkins, A J, E Klein, B, Klein, R, Ooi, T C, Rossing, P, Sattar, N, Stehouwer, C D A, Colhoun, H M & REMOVAL Trial Team 2017, ' Metformin in adults with type 1 diabetes : Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial ', Diabetes, Obesity and Metabolism, vol. 19, no. 4, pp. 509-516 . https://doi.org/10.1111/dom.12840
Diabetes, Obesity & Metabolism, 19(4), 509. Wiley-Blackwell
2017, ' Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial ', Diabetes, Obesity and Metabolism, vol. 19, no. 4 . https://doi.org/10.1111/dom.12840
Diabetes, Obesity & Metabolism
Diabetes Obesity & Metabolism, 19(4), 509-516. Wiley
Diabetes, Obesity & Metabolism, 19(4), 509. Wiley-Blackwell
2017, ' Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial ', Diabetes, Obesity and Metabolism, vol. 19, no. 4 . https://doi.org/10.1111/dom.12840
Diabetes, Obesity & Metabolism
Diabetes Obesity & Metabolism, 19(4), 509-516. Wiley
Aims: Cardiovascular (CV) disease is a major cause of reduced life expectancy in type 1 diabetes (T1D). Intensive insulin therapy prevents CV complications but is constrained by hypoglycaemia and weight gain. Adjunct metformin reduces insulin dose re
Autor:
Judy Sibayan, James Yong, Daniela Abt, Martin Tauschmann, Dominique Schaeffer, Malgorzata E Wilinska, Carlo L. Acerini, Elke Fröhlich-Reiterer, Craig Kollman, Nathan Cohen, Nicole Barber, Roman Hovorka, Julia K. Mader, Thomas Kapellen, Sonja Slegtenhorst, Emily Metcalfe, Gianluca Musolino, Katrin Nagl, Muriel Fichelle, Birgit Rami-Merhar, Alena Gerlinde Thiele, Fiona Campbell, Charlotte K. Boughton, Harald Kojzar, Carine de Beaufort, Maria Fritsch, Sabine E. Hofer, Ulrike Schierloh, Janet M. Allen
Publikováno v:
Diabetes Care
OBJECTIVE We aimed to assess the feasibility and safety of hybrid closed-loop insulin delivery in children with type 1 diabetes aged 1–7 years as well as evaluate the role of diluted insulin on glucose control. RESEARCH DESIGN AND METHODS In an ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e81c43f0da3015202b37770a210d97
Autor:
Gustaf J. Wellhagen, Kim Brøsen, Mette Marie Hougaard Christensen, Benjamin Guiastrennec, Maria C. Kjellsson, Tore Bjerregaard Stage
Publikováno v:
Stage, T B, Wellhagen, G, Christensen, M M H, Guiastrennec, B, Brøsen, K & Kjellsson, M C 2019, ' Using a semi-mechanistic model to identify the main sources of variability of metformin pharmacokinetics ', Basic & Clinical Pharmacology & Toxicology, vol. 124, no. 1, pp. 105-114 . https://doi.org/10.1111/bcpt.13139
Metformin pharmacokinetics (PK) is highly variable, and researchers have for years tried to shed light on determinants of inter-individual (IIV) and inter-occasion variability (IOV) of metformin PK. We set out to identify the main sources of PK varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34b5c811e89bad20db91948e42c2337
https://findresearcher.sdu.dk:8443/ws/files/146453151/Using_a_semi_mechanistic_model_to_identify_the_main_sources_of_variability_of_metformin_pharmacokinetics.pdf
https://findresearcher.sdu.dk:8443/ws/files/146453151/Using_a_semi_mechanistic_model_to_identify_the_main_sources_of_variability_of_metformin_pharmacokinetics.pdf