Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Hypervariable loop"'
Publikováno v:
Journal of Structural Biology: X, Vol 6, Iss , Pp 100054- (2022)
Anticalins are generated via combinatorial protein design on the basis of the lipocalin protein scaffold and constitute a novel class of small and robust engineered binding proteins that offer prospects for applications in medical therapy as well as
Externí odkaz:
https://doaj.org/article/02fdc000a41945079a939934635fe0e0
Autor:
Martina Gilodi, Simonetta Lisi, Erika F. Dudás, Marco Fantini, Rita Puglisi, Alexandra Louka, Paolo Marcatili, Antonino Cattaneo, Annalisa Pastore
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
Gilodi, M, Lisi, S, F. Dudás, E, Fantini, M, Puglisi, R, Louka, A, Marcatili, P, Cattaneo, A & Pastore, A 2022, ' Selection and Modelling of a New Single-Domain Intrabody Against TDP-43 ', Frontiers in Molecular Biosciences, vol. 8, 773234 . https://doi.org/10.3389/fmolb.2021.773234
Gilodi, M, Lisi, S, F. Dudás, E, Fantini, M, Puglisi, R, Louka, A, Marcatili, P, Cattaneo, A & Pastore, A 2022, ' Selection and Modelling of a New Single-Domain Intrabody Against TDP-43 ', Frontiers in Molecular Biosciences, vol. 8, 773234 . https://doi.org/10.3389/fmolb.2021.773234
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated to deteriorating motor and cognitive functions, and short survival. The disease is caused by neuronal death which results in progressive muscle wasting and weakness, ultim
Publikováno v:
Journal of Structural Biology: X
Journal of Structural Biology: X, Vol 6, Iss, Pp 100054-(2022)
Journal of Structural Biology: X, Vol 6, Iss, Pp 100054-(2022)
Graphical abstract
Highlights • The lipocalins exhibit four structurally variable loops at one end of a β-barrel. • Binding sites for diverse ligands occur in the natural lipocalin family members. • Loop reshaping via combinatorial protei
Highlights • The lipocalins exhibit four structurally variable loops at one end of a β-barrel. • Binding sites for diverse ligands occur in the natural lipocalin family members. • Loop reshaping via combinatorial protei
Autor:
Paul Labute, Johannes K. X. Maier
Publikováno v:
Proteins
The success of antibody-based drugs has led to an increased demand for predictive computational tools to assist antibody engineering efforts surrounding the six hypervariable loop regions making up the antigen binding site. Accurate computational mod
Autor:
Michael Schantz Klausen, Paolo Marcatili, Morten Nielsen, Mads Valdemar Anderson, Martin Closter Jespersen
Publikováno v:
Klausen, M S, Anderson, M V, Jespersen, M C, Nielsen, M & Marcatili, P 2015, ' LYRA, a webserver for lymphocyte receptor structural modeling. ', Nucleic Acids Research, vol. 43, no. W1, pp. W349-W355 . https://doi.org/10.1093/nar/gkv535
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Nucleic Acids Research
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Nucleic Acids Research
The accurate structural modeling of B- and T-cell receptors is fundamental to gain a detailed insight in the mechanisms underlying immunity and in developing new drugs and therapies. The LYRA (LYmphocyte Receptor Automated modeling) web server (http:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824c2a0ae84d5bbe437ed91438fedd52
https://orbit.dtu.dk/en/publications/02ab83a1-042b-4abc-8949-70b9d3780d9a
https://orbit.dtu.dk/en/publications/02ab83a1-042b-4abc-8949-70b9d3780d9a
Publikováno v:
The Journal of Experimental Medicine
The role of two central residues (K68, E69) of the fourth hypervariable loop of the Vα domain (HV4α) in antigen recognition by an MHC class II–restricted T cell receptor (TCR) has been analyzed. The TCR recognizes the NH2-terminal peptide of myel
Autor:
Tsuguto Fujimoto, Arun Kumar Adhikary, Nobuhiko Okabe, Yoko Ishimaru, Atsuko Kano, Nozomu Hanaoka, Etsuko Nakajima, Hideaki Shimizu, Yuki Matsushima
Publikováno v:
Japanese journal of infectious diseases. 65(3)
A local outbreak of epidemic keratoconjunctivitis (EKC) caused by human adenovirus type 8 (HAdV-D8) occurred in Kawasaki city, Japan in July-August 2011. Since the cases were sporadic in nature, the source of the infection could not be identified. Th
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Biopolymers
Biopolymers, Wiley, 1992, 32, pp.33-43
Biopolymers, Wiley, 1992, 32, pp.33-43
An extended simulated annealing process (ESAP) has been developed in order to obtain an ensemble of conformations of a peptide segment from a protein fluctuating at a given temperature. The annealing process was performed with a fast Monte Carlo meth
Autor:
LK Ching, L Stamatatos
Publikováno v:
Retrovirology, Vol 6, Iss Suppl 3, p P326 (2009)
Retrovirology
Retrovirology