Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Hyperproinsulinemia"'
Publikováno v:
Clinical Medicine Insights: Case Reports, Vol 14 (2021)
Clinical Medicine Insights. Case Reports
Clinical Medicine Insights. Case Reports
Introduction:Insulin is synthesized in the β-cells from preproinsulin. Preproinsulin becomes proinsulin after leaving the signal peptide. Proinsulin is separated into C-peptide and insulin by 2 enzymes. Hyperproinsulinemia is suspected to be a pancr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e28136834654be04d27e15c8dee95e4
https://doaj.org/article/b0f3a58463e44388b812b088ef257214
https://doaj.org/article/b0f3a58463e44388b812b088ef257214
Autor:
Yupei Zhao, Chunmei Bai, Naishi Li, Yuan-Jia Chen, Qiang Wang, Yu-Li Song, Yu Xiao, Hai-Yan Wu, Ming Li, Shuang Yu
Publikováno v:
BASE-Bielefeld Academic Search Engine
Endocrine
Endocrine
Background Insulinoma is a subtype of pancreatic neuroendocrine tumors. Many patients with insulinoma are obese due to frequent food intake. Ghrelin is associated with obesity and blood levels of insulin. It is not clear if plasma levels of ghrelin i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd17d8312663f84273490bda97d18498
https://doi.org/10.1007/s12020-020-02233-4
https://doi.org/10.1007/s12020-020-02233-4
Autor:
Jeffrey, Kristin D., Alejandro, Emilyn U., Luciani, Dan S., Kalynyak, Tatyana B., Hu, Xiaoke, Li, Hong, Lin, Yalin, Townsend, R. Reid, Polonsky, Kenneth S., Johnson, James D.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2008 Jun . 105(24), 8452-8457.
Externí odkaz:
https://www.jstor.org/stable/25462802
Autor:
O N Poteryaeva, I F Usynin
Publikováno v:
Russian Clinical Laboratory Diagnostics. 64:397-404
Proinsulin is one of the indicators reflecting the functional activity of the pancreas. In insulin-independent diabetes mellitus the ratio proinsulin / insulin is increased. The review examined the causes of hyperproinsulinemia and the diagnostic val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa50d35ae6f92e5702501fc4270019a
https://doi.org/10.18821/0869-2084-2019-64-7-397-404
https://doi.org/10.18821/0869-2084-2019-64-7-397-404
Publikováno v:
Journal of Biological Chemistry. 294:13040-13050
An early hallmark of type 2 diabetes is a failure of proinsulin-to-insulin processing in pancreatic β-cells, resulting in hyperproinsulinemia. Proinsulin processing is quite sensitive to nutrient flux, and β-cell–specific deletion of the nutrient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a7d4613dd3abe91d22a4019408eeb67
https://doi.org/10.1074/jbc.ra119.008670
https://doi.org/10.1074/jbc.ra119.008670
Autor:
Carroll, Raymond J., Hammer, Robert E., Chan, Shu Jin, Swift, Hewson H., Rubenstein, Arthur H., Steiner, Donald F.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1988 Dec 01. 85(23), 8943-8947.
Externí odkaz:
https://www.jstor.org/stable/32862
Autor:
Agustín F. González-Rivero, Miguel A. González-Gay, Antonia de Vera-González, Alejandra González-Delgado, Felix Francisco-Hernández, Lilian Medina-Vega, Iñigo Rúa-Figueroa, Iván Ferraz-Amaro, Juan Carlos Quevedo-Abeledo, Alicia García-Dorta
Publikováno v:
Rheumatology.
Objectives To investigate how markers of beta-cell secretion (proinsulin-processing metabolites) are expressed in SLE patients and their potential relation to features associated with the disease such as activity or damage. Methods One hundred and fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a92a762d31aba6b50a48201a73139a
https://doi.org/10.1093/rheumatology/keaa874
https://doi.org/10.1093/rheumatology/keaa874
Autor:
Giuseppe Quero, Simona Moffa, Andrea Giaccari, Gian Pio Sorice, Sergio Alfieri, Chiara Maria Assunta Cefalo, Franco Folli, Alfredo Pontecorvi, Pietro Manuel Ferraro, Andrea Mari, Francesca Cinti, Vinsin A. Sun, Teresa Mezza
Publikováno v:
Diabetes. 67:2389-2396
Increased proinsulin secretion, which characterizes type 2 diabetes and insulin resistance, may be due to an intrinsic, primitive defect in proinsulin processing or be secondary to increased demand on β-cells (hyperinsulinemia secondary to insulin r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57025721ebd1f825b3a17f52b672e70
https://doi.org/10.2337/db18-0279
https://doi.org/10.2337/db18-0279
Akademický článek
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Autor:
Michael Einer Røder
Publikováno v:
Expert review of endocrinologymetabolism. 12(4)
Disproportionately elevated fasting levels of proinsulin immunoreactive material (PIM)relative to insulin immunoreactivity (IRI) are a well-established abnormality in type 2 diabetes. Thesignificance of this abnormality has been investigated and disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b89e406a418d6ff276e517045132d7b
https://pubmed.ncbi.nlm.nih.gov/30058886
https://pubmed.ncbi.nlm.nih.gov/30058886