Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES

Autor: Gregory G. Schwartz, Philippe Gabriel Steg, Željko Reiner, Shaun G. Goodman, Pablo Carlos Montenegro Valdovinos, Robert Pordy, Vera Bittner, Harvey D. White, Andreas M. Zeiher, Laurien E Zijlstra, Michael Szarek, J. Wouter Jukema, Hung-Fat Tse, Matthew T. Roe, Rafael Diaz, Deepak L. Bhatt, Heinz Drexel, Yong-Un Kim

Publikováno v: Circulation, 140(25), 2054-2062. LIPPINCOTT WILLIAMS & WILKINS
Jukema, J Wouter; Zijlstra, Laurien E; Bhatt, Deepak L; Bittner, Vera A; Diaz, Rafael; Drexel, Heinz; Goodman, Shaun G; Kim, Yong-Un; Pordy, Robert; Reiner, Zeljko; Roe, Matthew T; Tse, Hung Fat; Valdovinos, Pablo Carlos Montenegro; White, Harvey D; Zeiher, Andreas M; Szarek, Michael; Schwartz, Gregory G; Steg, Philippe Gabriel (2019). Effect of Alirocumab on Stroke in ODYSSEY OUTCOMES. Circulation, 140(25), pp. 2054-2062. American Heart Association 10.1161/CIRCULATIONAHA.119.043826
Circulation

Background: Lowering of atherogenic lipoproteins, including low-density lipoprotein cholesterol (LDL-C), reduces the risk of ischemic stroke. However, concerns have been raised about very low LDL-C levels and a potential increased risk of hemorrhagic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be12a05ca96111cb0d2addf0c1aae229
https://doi.org/10.1161/circulationaha.119.043826

Effect of Alirocumab on Mortality After Acute Coronary Syndromes An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial

Autor: Steg, PG, Szarek, M, Bhatt, DL, Bittner, VA, Bregeault, M-F, Dalby, AJ, Diaz, R, Edelberg, JM, Goodman, SG, Hanotin, C, Harrington, RA, Jukema, JW, Lecorps, G, Mahaffey, KW, Moryusef, A, Ostadal, P, Parkhomenko, A, Pordy, R, Roe, MT, Tricoci, P, Vogel, R, White, HD, Zeiher, AM, Schwartz, GG, Sasiela, WJ, Tamby, J-F, Aylward, PE, Drexel, H, Sinnaeve, P, Dilic, M, Gotcheva, NN, Prieto, J-C, Yong, H, Lopez-Jaramillo, P, Pecin, I, Reiner, Z, Poulsen, SH, Viigimaa, M, Nieminen, MS, Danchin, N, Chumburidze, V, Marx, N, Liberopoulos, E, Valdovinos, PCM, Tse, H-F, Kiss, RG, Xavier, D, Zahger, D, Valgimigli, M, Kimura, T, Kim, HS, Kim, S-H, Kedev, S, Erglis, A, Laucevicius, A, Yusoff, K, Lopez, R, Ramos Lopez, GA, Alings, M, Halvorsen, S, Correa Flores, RM, Sy, RG, Budaj, A, Morais, J, Dorobantu, M, Karpov, Y, Ristic, AD, Chua, T, Murin, J, Fras, Z, Tunon, J, De Silva, HA, Hagstrom, E, Muller, C, Chiang, C-E, Sritara, P, Guneri, S, Ray, KK, Moriarty, PM, Chaitman, B, Kelsey, SF, Olsson, AG, Rouleau, J-L, Simoons, ML, Alexander, K, Meloni, C, Rosenson, R, Sijbrands, EJG, Alexander, JH, Armaganijan, L, Bagai, A, Bahit, MC, Brennan, JM, Clifton, S, DeVore, AD, Deloatch, S, Dickey, S, Dombrowski, K, Ducrocq, G, Eapen, Z, Endsley, P, Eppinger, A, Harrison, RW, Hess, CN, Hlatky, MA, Jordan, JD, Knowles, JW, Kolls, BJ, Kong, DF, Leonardi, S, Lillis, L, Maron, DJ, Marcus, J, Mathews, R, Mehta, RH, Mentz, RJ, Moreira, HG, Patel, CB, Pereira, SB, Perkins, L, Povsic, TJ, Puymirat, E, Jones, WS, Shah, BR, Sherwood, MW, Stringfellow, K, Sujjavanich, D, Toma, M, Van Diepen, SFP, Wilson, MD, Yan, AT-K, Lopes, RD, Trotter, C, Schiavi, LB, Garrido, M, Alvarisqueta, AF, Sassone, SA, Bordonava, AP, Alves De Lima, AE, Schmidberg, JM, Duronto, EA, Caruso, OC, Novaretto, LP, Angel Hominal, M, Montana, OR, Caccavo, A, Gomez Vilamajo, OA, Lorenzatti, AJ, Cartasegna, LR, Paterlini, GA, Mackinnon, IJ, Caime, GD, Amuchastegui, M, Salomone, R, Codutti, OR, Jure, HO, Bono, JOE, Hrabar, AD, Vallejos, JA, Ahuad Guerrero, RA, Novoa, F, Patocchi, CA, Zaidman, CJ, Giuliano, ME, Dran, RD, Vico, ML, Carnero, GS, Guzman, PN, Medrano Allende, JC, Garcia Brasca, DF, Bustamante Labarta, MH, Nani, S, Blumberg, EDS, Colombo, HR, Liberman, A, Luciardi, HL, Waisman, GD, Berli, MA, Duran, ROG, Cestari, HG, Luquez, HA, Giordano, JA, Saavedra, SS, Zapata, G, Costamagna, O, Llois, S, Waites, JH, Collins, N, Soward, A, Hii, CLS, Shaw, J, Arstall, MA, Horowitz, J, Rogers, JF, Colquhoun, D, Oqueli Flores, RE, Roberts-Thomson, P, Raffel, O, Lehman, SJ, Aroney, C, Coverdale, SGM, Garrahy, PJ, Starmer, G, Sader, M, Carroll, PA, Dick, R, Zweiker, R, Hoppe, U, Huber, K, Berger, R, Weidinger, F, Faes, D, Hermans, K, Pirenne, B, Leone, A, Hoffer, E, Vrolix, MCM, De Wolf, L, Wollaert, B, Castadot, M, Dujardin, K, Beauloye, C, Vervoort, G, Striekwold, H, Convens, C, Roosen, J, Barbato, E, Claeys, M, Cools, F, Terzic, I, Barakovic, F, Midzic, Z, Pojskic, B, Fazlibegovic, E, Durak-Nalbantic, A, Vulic, 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Publikováno v: Circulation
Steg, P G, Szarek, M, Bhatt, D L, Bittner, V A, Bregeault, M-F, Dalby, A J, Diaz, R, Edelberg, J M, Goodman, S G, Hanotin, C, Harrington, R A, Jukema, J W, Lecorps, G, Mahaffey, K W, Moryusef, A, Ostadal, P, Parkhomenko, A, Pordy, R, Roe, M T, Tricoci, P, Vogel, R, White, H D, Zeiher, A M, Schwartz, G G, ODYSSEY OUTCOMES Committees and Investigators, Clemmensen, P, Gislason, G, Davidsen, F & Videbaek, L 2019, ' Effect of Alirocumab on Mortality After Acute Coronary Syndromes : An Analysis of the ODYSSEY OUTCOMES Randomized Clinical Trial ', Circulation, vol. 140, no. 2, pp. 103-112 . https://doi.org/10.1161/CIRCULATIONAHA.118.038840
CIRCULATION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Circulation, 140(2), 103-112. LIPPINCOTT WILLIAMS & WILKINS
Circulation : an official journal of the American Heart Association 140(2), 103-112 (2019). doi:10.1161/CIRCULATIONAHA.118.038840

bastos, jose/0000-0002-9526-3123; Manakshe, Gajendra/0000-0002-4983-4271; Tse, Hung Fat/0000-0002-9578-7808; Gislason, Gunnar H/0000-0002-0548-402X; Taskinen, Marja-Riitta/0000-0002-6229-3588; Racca, Vittorio/0000-0002-4465-3789; Keskin, Kudret/0000-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4916ac726c042210182cdbd1d204ce0
https://hdl.handle.net/10067/1812340151162165141

The Expected Cardiovascular Benefit of Plasma Cholesterol Lowering with or Without LDL-C Targets in Healthy Individuals at Higher Cardiovascular Risk

Autor: Viviane A. Valente, Fernando H. Y. Cesena, Márcio Sommer Bittencourt, Raul D. Santos, Raquel D. Conceição, Antonio G. Laurinavicius

Publikováno v: Arquivos Brasileiros de Cardiologia v.108 n.6 2017
Arquivos Brasileiros de Cardiologia
Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
Arquivos Brasileiros de Cardiologia, Vol 108, Iss 6, Pp 518-525

There is controversy whether management of blood cholesterol should be based or not on LDL-cholesterol (LDL-c) target concentrations.To compare the estimated impact of different lipid-lowering strategies, based or not on LDL-c targets, on the risk of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2354b106398d58ea93619fcfb00286ba
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2017000600518

Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy

Autor: Mark K. Wedel, Mieke D. Trip, John Su, Erik S.G. Stroes, J. Wouter Jukema, Eric J.G. Sijbrands, Diane Tribble, Brenda F. Baker, John J.P. Kastelein, Rosie Z. Yu, JoAnn Flaim, Fatima Akdim

Publikováno v: Journal of the American College of Cardiology, 55(15), 1611-1618. Elsevier Inc.
Journal of the American College of Cardiology, 55(15), 1611-1618
Journal of the American College of Cardiology, 55(15), 1611-1618. Elsevier USA

Objectives The aim of this study was to evaluate the efficacy and safety of mipomersen in hypercholesterolemic subjects taking stable statin therapy. Background Mipomersen is an apolipoprotein (apo) B synthesis inhibitor that has demonstrated signifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e754c064d779a828122d09d679769d0

Energy availability and the female athlete triad in elite endurance athletes

Autor: Melin, Anna Katarina, Tornberg, Åsa B, Skouby, Sven O, Møller, S S, Sundgot-Borgen, Jorunn, Faber, Jens, Sidelmann, Johannes Jakobsen, Aziz, Mubeena, Sjödin, Anders

Publikováno v: Melin, A K, Tornberg, Å B, Skouby, S O, Møller, S S, Sundgot-Borgen, J, Faber, J, Sidelmann, J J, Aziz, M & Sjödin, A 2015, ' Energy availability and the female athlete triad in elite endurance athletes ', Scandinavian Journal of Medicine & Science in Sports, vol. 25, no. 5, pp. 610-622 . https://doi.org/10.1111/sms.12261

The female athlete triad (Triad), links low energy availability (EA), with menstrual dysfunction (MD), and impaired bone health. The aims of this study were to examine associations between EA/MD and energy metabolism and the prevalence of Triad-assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3062::6e45c59cc4e712554d18737bc6637ee0
https://portal.findresearcher.sdu.dk/da/publications/31c23ad3-8d9a-4cce-bacd-7b66bff9f72e