Zobrazeno 1 - 10
of 3 109
pro vyhledávání: '"Hyperactivation"'
Autor:
Patrick A. H. Ehm, Stefan Horn, Konstantin Hoffer, Malte Kriegs, Michael Horn, Susanne Giehler, Marcus Nalaskowski, Christoph Rehbach, Martin A. Horstmann, Manfred Jücker
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract Inhibitory phosphatases, such as the inositol-5-phosphatase SHIP1 could potentially contribute to B-cell acute lymphoblastic leukemia (B-ALL) by raising the threshold for activation of the autoimmunity checkpoint, allowing malignant cells wi
Externí odkaz:
https://doaj.org/article/0e544bc1fd344d7d8ce0baab81ce998e
Autor:
Lucas N. González, María M. Giaccagli, Jael D. Herzfeld, Patricia S. Cuasnicú, Vanina G. Da Ros, Débora J. Cohen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract To acquire the ability to fertilize the egg, mammalian spermatozoa must undergo a series of changes occurring within the highly synchronized and specialized environment of the female reproductive tract, collectively known as capacitation. In
Externí odkaz:
https://doaj.org/article/cff7940c78974242ae7798d71dbfae7b
Autor:
Jae Yeon Hwang
Publikováno v:
Journal of Animal Science and Technology, Vol 66, Iss 3, Pp 443-456 (2024)
In female tract, mammalian sperm develop hyperactivated motility which is a key physiological event for sperm to fertilize eggs. This motility change is triggered by Ca2+ influx via the sperm-specific Ca2+ channel, CatSper. Although previous studies
Externí odkaz:
https://doaj.org/article/250a5ca56c314dce87e7e8f01b6c3e96
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 7, Pp 100579- (2024)
Sterol-regulatory element binding proteins (SREBPs) are a conserved transcription factor family governing lipid metabolism. When cellular cholesterol level is low, SREBP2 is transported from the endoplasmic reticulum to the Golgi apparatus where it u
Externí odkaz:
https://doaj.org/article/1b410202ecc54384989c6ac7afa1299e
Autor:
M. A. Manukyan, A. Yu. Falkovskaya, V. F. Mordovin, I. V. Zyubanova, V. A. Lichikaki, E. I. Solonskaya, A. A. Vtorushina, S. A. Khunkhinova, I. A. Skomkina, V. V. Rudenko, T. Yu. Rebrova, E. F. Muslimova, S. A. Afanasyev
Publikováno v:
Российский кардиологический журнал, Vol 29, Iss 5 (2024)
Aim. To assess the functional state of the sympathetic nervous system according to β-adrenergic reactivity of erythrocyte membranes (EM) in patients with refractory (rfHTN) and resistant hypertension (rHTN) in relation to target organ damage.Materia
Externí odkaz:
https://doaj.org/article/6ea2983637404f52ae7acdce20a34e29
Publikováno v:
Российский кардиологический журнал, Vol 29, Iss 2S (2024)
The review systematizes the latest data on renal denervation (RDN) potential in the treatment of pathologies associated with sympathetic hyperactivation. Despite the controversial results obtained at the beginning of its clinical application, the ant
Externí odkaz:
https://doaj.org/article/5bb6518d2651485d8e1e7387199c017e
Autor:
Nanako Murata, Kana Nishimura, Naoki Harada, Tomoya Kitakaze, Eiji Yoshihara, Hiroshi Inui, Ryoichi Yamaji
Publikováno v:
Physiological Reports, Vol 12, Iss 12, Pp n/a-n/a (2024)
Abstract Pancreatic β‐cell mass is a critical determinant of insulin secretion. Severe endoplasmic reticulum (ER) stress causes β‐cell apoptosis; however, the mechanisms of progression and suppression are not yet fully understood. Here, we repo
Externí odkaz:
https://doaj.org/article/9af5d9aa7f5044e087cabcdccaa9575d
Progesterone and estradiol regulate sperm hyperactivation and in vitro fertilization success in mice
Autor:
Miyu FUJIKURA, Masakatsu FUJINOKI
Publikováno v:
The Journal of Reproduction and Development, Vol 70, Iss 2, Pp 96-103 (2024)
Progesterone (P) and 17β-estradiol (Eβ) form the well-known hormone pair that regulates sperm capacitation. Here, we examined the regulatory effects of P and Eβ on sperm hyperactivation in mice and evaluated the in vitro fertilization (IVF) succes
Externí odkaz:
https://doaj.org/article/190131e4b62a4d8495d6639b18474006
Autor:
Yuki MIYAZAWA, Masakatsu FUJINOKI
Publikováno v:
The Journal of Reproduction and Development, Vol 69, Iss 5, Pp 279-290 (2023)
Progesterone (P) is a well-known enhancer of hyperactivation which is associated with the success of in vitro fertilization (IVF). In this study, we examined whether P-enhanced hyperactivation affected IVF success in rats. When rat spermatozoa were e
Externí odkaz:
https://doaj.org/article/9164a28607f14dea88f74d3e58626fcc
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 9, Pp 6995-7010 (2023)
After sperm enter the female reproductive tract, the physicochemical and biochemical microenvironment undergoes significant changes. In particular, the large changes in various ions encountered by sperm may alter the physiology of sperm, ultimately c
Externí odkaz:
https://doaj.org/article/0068ff5ff7b94fbface726e67d478053