Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Hyock Joo Kwon"'
Autor:
Ilean Chai, Dmytro Kornyeyev, Edward Hsieh, Gesham Magombedze, Lance Stapleton, Magdeleine Hung, Hyock Joo Kwon, Erin Stefanutti, JeanPhilippe Belzile, Gregg Czerwieniec, Adele Y. Wang, Mariya Morar, Latesh Lad
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) checkpoint blockade is central to Immuno-Oncology based therapies, and alternatives to antibody blockers of this interaction are an active area of research due to antibody relat
Externí odkaz:
https://doaj.org/article/852440356267466d840a0d3719af6b2a
Autor:
Fiorella Ghisays, Cynthia S. Brace, Shawn M. Yackly, Hyock Joo Kwon, Kathryn F. Mills, Elena Kashentseva, Igor P. Dmitriev, David T. Curiel, Shin-ichiro Imai, Tom Ellenberger
Publikováno v:
Cell Reports, Vol 10, Iss 10, Pp 1665-1673 (2015)
The NAD+-dependent protein deacetylase SIRT1 regulates energy metabolism, responses to stress, and aging by deacetylating many different proteins, including histones and transcription factors. The mechanisms controlling SIRT1 enzymatic activity are c
Externí odkaz:
https://doaj.org/article/3c0233978c70441d9ae8a5b0bac7801b
Autor:
Hyock Joo Kwon, Weimei Xing, Katie Chan, Anita Niedziela-Majka, Katherine M Brendza, Thorsten Kirschberg, Darryl Kato, John O Link, Guofeng Cheng, Xiaohong Liu, Roman Sakowicz
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122844 (2015)
Ledipasvir, a direct acting antiviral agent (DAA) targeting the Hepatitis C Virus NS5A protein, exhibits picomolar activity in replicon cells. While its mechanism of action is unclear, mutations that confer resistance to ledipasvir in HCV replicon ce
Externí odkaz:
https://doaj.org/article/2ec4378953f54de7b0076a7adeb703bd
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18722 (2011)
NPC1L1 is the molecular target of the cholesterol lowering drug Ezetimibe and mediates the intestinal absorption of cholesterol. Inhibition or deletion of NPC1L1 reduces intestinal cholesterol absorption, resulting in reduction of plasma cholesterol
Externí odkaz:
https://doaj.org/article/f0f45cbf4d164a31a931bb171a343515
Autor:
Jiri Vlach, Alexandra B. Samal, Anita Niedziela-Majka, Michael V. Lee, Giuseppe A. Papalia, Melanie H. Wong, Katherine M. Brendza, Brian E. Schultz, Dmitry O. Koltun, Hyock Joo Kwon, Joy Y. Feng, Roman Sakowicz, Nikolai Novikov, Jamil S. Saad
Publikováno v:
Journal of Molecular Biology. 431:1440-1459
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. CaMKII is activated by calcium-bound calmodulin (Ca2+/CaM) through a direct bin
Autor:
Christine E. Bowman, Ada Chen, Damie Juat, Kaustubh Parashar, Julie Clor, Hema Singh, Ritu Kushwaha, Bryan Handlos, Suan Liu, Janine Kline, Xiaoning Zhao, Hyock Joo Kwon, David Green, Stephen W. Young, Ester Fernandez-Salas, Matthew J. Walters, Nigel P. Walker
Publikováno v:
Cancer Research. 82:321-321
CD39 (ENTPD1) is an ecto-nucleoside triphosphate diphosphohydrolase expressed widely in the tumor microenvironment (TME) responsible for catalyzing the conversion of ATP to AMP. Inhibition of CD39 enzymatic activity can promote anti-tumor immune resp
Autor:
Martin Hubálek, Dhivya Ramakrishnan, Rudolf K. F. Beran, Saketh Chemuru, Henry W. Rohrs, Hyock Joo Kwon, Upasana Mehra, Weimei Xing, Iva Pichová, Michael L. Gross, Bruno Marchand, Michal Doležal, Anita Niedziela-Majka, Aleš Zábranský, Simon P. Fletcher
Publikováno v:
Journal of Virology
The structural maintenance of chromosomes 5/6 complex (Smc5/6) is a host restriction factor that suppresses HBV transcription. HBV counters this restriction by expressing HBV X protein (HBx), which redirects a host ubiquitin ligase to target Smc5/6 f
Autor:
Hyock Joo Kwon, Christian Voitenleitner, Weimei Xing, Dmytro Kornyeyev, Simon P. Fletcher, Magdeleine Hung, Christine M. Livingston, Dhivya Ramakrishnan, Rudolf K. F. Beran
Publikováno v:
Journal of Virology
Hepatitis B virus X protein (HBx) is a promising drug target since it promotes the degradation of the host structural maintenance of chromosomes 5/6 complex (Smc5/6) that inhibits HBV transcription. To date, it has not been possible to study HBx in p
Autor:
Melanie H, Wong, Alexandra B, Samal, Mike, Lee, Jiri, Vlach, Nikolai, Novikov, Anita, Niedziela-Majka, Joy Y, Feng, Dmitry O, Koltun, Katherine M, Brendza, Hyock Joo, Kwon, Brian E, Schultz, Roman, Sakowicz, Jamil S, Saad, Giuseppe A, Papalia
Publikováno v:
Journal of molecular biology. 431(7)
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. CaMKII is activated by calcium-bound calmodulin (Ca
Autor:
Madeleine Willkom, Gabriel Birkus, Weimei Xing, Esmeralda Aguayo, Joy Y. Feng, Mike Clarke, Annapurna Sapre, Brian E. Schultz, Roman Sakowicz, Hyock Joo Kwon, Ona Barauskas
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 10, p e0185998 (2017)
PLoS ONE, Vol 12, Iss 10, p e0185998 (2017)
Influenza polymerase is a heterotrimer protein with both endonuclease and RNA-dependent RNA polymerase (RdRp) activity. It plays a critical role in viral RNA replication and transcription and has been targeted for antiviral drug development. In this